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    v1.0.28
    OpenPayerBilling CodesDestruction by Neurolytic Agent (eg, Chemical, Thermal, Electrical or Radiofrequency) Procedures on the Somatic NervesCPT cpt-64644-chemical-injection-five-or-more-muscles-one-extremity
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    CPT 64644: Chemodenervation of 5+ Muscles in One Extremity

    Medicare pays $196 on average nationally for this procedure.

    CPT code 64644 describes a chemodenervation procedure in which the provider injects a neurolytic agent (for example, botulinum toxin such as Botox®) into five or more muscles of a single extremity to relieve pain and muscle spasms; this is a therapeutic injection service typically performed in an ambulatory clinic or outpatient procedural setting and is classified as a targeted muscle injection procedure for focal spasticity and pain management.

    For related coverage guidance, see recent payer policy updates: Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use Disorders, Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use Disorders, Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use Disorders.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult with focal spasticity or symptomatic muscle overactivity of one upper or lower extremity following stroke, traumatic brain injury, multiple sclerosis, or cerebral palsy. The patient presents to an outpatient neurology, physiatry, or orthopedic clinic for evaluation of persistent painful muscle spasms and limited function despite oral antispasmodic therapy and physical therapy. After evaluation, the provider discusses chemodenervation with onabotulinumtoxinA (Botox®) targeting five or more muscles in one extremity to reduce spastic hypertonicity and pain and to improve range of motion and ease of caregiving.

    The clinical workflow includes an initial history and focused neurologic/musculoskeletal exam, review of prior therapies, informed consent, and documentation of target muscles and estimated units. On the day of service the patient is positioned in an exam or procedure room in an outpatient clinic, ambulatory surgery center, or hospital outpatient department. The provider performs localization by palpation, anatomic landmarks, or adjunctive electromyography (EMG) or ultrasound guidance if clinically indicated, then injects the toxin into five or more muscles of the affected extremity. Post-procedure observation, discharge instructions, and scheduling of follow-up for outcome assessment and potential repeat injections are documented.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    64644Chemodenervation of 5 or more muscles, one extremity, injected with neurolytic agent (e.g., botulinum toxin)Primary procedure for focal spasticity management targeting five or more muscles in a single extremity.
    39501Injection of anesthetic agent and/or steroid into peripheral nerve(s) or ganglion, single peripheral nerveMay be performed for diagnostic or adjunctive pain control but is a different service; not typically billed with 64644 on same site/time.
    95886Needle electromyography for guidance in needle placement, 1 extremity with 1–3 musclesEMG guidance codes such as 95886 may be used to localize muscles for injection when billed and documented separately.
    76942Ultrasonic guidance for needle placement (e.g., for injections)Ultrasound guidance for localization may be performed and billed separately when documentation supports its medical necessity.
    99070Supplies and materials provided by the physician over and above those usually included with the office visitUsed to report additional supplies (e.g., special needles, toxin preparation) associated with the procedure when payer permits.
    J0585Injection, onabotulinumtoxinA, 1 unitDrug administration code to report the vial/unit quantity of onabotulinumtoxinA when required by payer for drug billing and inventory tracking.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    25CPT modifier 25 indicates that on the same day as another procedure or service, the same physician or other qualified health care professional provided a significant, separately identifiable…- When to apply: Use modifier 25 only on an E/M code to indicate the same provider delivered a significant, separately identifiable E/M service on the same day as another procedure or service — i.e.,…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207RH0000XHematology (Internal Medicine) PhysicianAn internist with additional training who specializes in diseases of the blood, spleen and lymph. This specialist treats conditions such as anemia, cl…
    2084P0800XPsychiatry PhysicianA Psychiatrist specializes in the prevention, diagnosis, and treatment of mental disorders, emotional disorders, psychotic disorders, mood disorders, …
    207K00000XAllergy & Immunology PhysicianAn allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
    363A00000XPhysician AssistantA physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
    207W00000XOphthalmology PhysicianAn ophthalmologist has the knowledge and professional skills needed to provide comprehensive eye and vision care. Ophthalmologists are medically train…
    101YM0800XMental Health CounselorBehavioral Health & Social Service Providers · Counselor
    261QX0100XOccupational Medicine Clinic/CenterAmbulatory Health Care Facilities · Clinic/Center
    364SH0200XHome Health Clinical Nurse SpecialistPhysician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist

    Related ICD-10-CM Codes

    25 rows

    ICD-10-CM CodeDescription
    G24.01Drug induced subacute dyskinesia
    G24.02Drug induced acute dystonia
    G24.09Other drug induced dystonia
    G24.2Idiopathic nonfamilial dystonia
    G24.3Spasmodic torticollis
    G24.4Idiopathic orofacial dystonia
    G25.4Drug-induced chorea
    G25.89Other specified extrapyramidal and movement disorders
    G81.90Hemiplegia, unspecified affecting unspecified side
    G81.91Hemiplegia, unspecified affecting right dominant side

    Showing 1–10 of 25

    Related Payer Policy Updates

    Specialty: Anesthesiology1 / 3

    10 rows

    PolicyPayerEffective Date
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Elective Inpatient Services (for Idaho Only)UnitedHealthcare2026-06-01
    Sites of Servicepriority health2026-06-01
    Coverage for Ambulatory Surgery Unit (ASU)/Outpatient Facility and Anesthesia for Dental Servicesuniverahealthcare2026-05-21
    Mm_0579_Coveragepositioncriteria_Anesthesia_Services_Selected_Nerve_BlocksCigna2026-05-15
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric DisordersBlue Cross Blue Shield - North Carolina2026-04-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric DisordersBlue Cross Blue Shield - North Carolina2026-04-01

    Related Codes

    CPT-64600-TRIGEMINAL-NERVE-NEURODESTRUCTIVE-INJECTION

    CPT 64600: Trigeminal Nerve Neurodestruction by Injection

    CPT-64605-TRIGEMINAL-NERVE-NEURODESTRUCTIVE-INJECTION

    CPT 64605: Trigeminal Nerve Neurodestructive Injection

    CPT-64610-TRIGEMINAL-NERVE-NEURODESTRUCTIVE-INJECTION

    CPT 64610: Trigeminal Nerve Neurodestructive Injection

    CPT-64611-SALIVARY-GLAND-CHEMICAL-DENERVATION-BILATERAL

    CPT 64611: Bilateral Salivary Gland Chemical Injection for Sialorrhea

    CPT-64612-FACIAL-NERVE-CHEMICAL-NEUROLYSIS-UNILATERAL

    CPT 64612: Facial Nerve Chemical Neurolysis, Unilateral

    CPT-64615-BILATERAL-CHEMICAL-DENERVATION-FACIAL-CERVICAL-MUSCLES

    CPT 64615: Bilateral Chemical Denervation of Head and Neck Muscles

    CPT-64616-UNILATERAL-CERVICAL-MUSCLE-CHEMICAL-DENERVATION

    CPT 64616: Unilateral Neck Muscle Chemodenervation

    CPT-64617-PERCUTANEOUS-LARYNGEAL-CHEMODENERVATION-UNILATERAL

    CPT 64617: Percutaneous Chemodenervation of Larynx, Unilateral

    CPT-64620-INTERCOSTAL-NERVE-ABLATION

    CPT 64620: Intercostal Nerve Destruction (Chemical/Heat/Radiofrequency)

    CPT-64624-GENICULAR-NERVE-NEUROLYSIS-KNEE

    CPT 64624: Genicular Nerve Neurolysis for Knee Pain

    Showing 1–10 of 26

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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