Find policies, billing codes, payers, states, and providers

CPT 64620: Intercostal Nerve Ablation Procedure

CPT code 64620: Intercostal nerve destruction by chemical, heat, or radiofrequency methods is a targeted neurolytic procedure used to treat refractory intercostal neuropathic pain and cancer-related chest wall or rib pain. Nationally, this code captures procedures that can provide durable pain relief when conservative therapies fail, and it is relevant for pain management, interventional radiology, anesthesiology, and surgical practices.

Key payers covered in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise clinical context for when the procedure is performed, typical sites of service, and the range of common billing modifiers associated with this service. The publication summarizes standard coding use, payer coverage considerations, and benchmarks for utilization where available.

This summary provides clinicians, billing professionals, and policy analysts with an overview of clinical purpose, payer landscape, and the types of information necessary for accurate claims submission and reimbursement review. Data not available in the input is noted where applicable.

Customize your policy alerts

Sign up for cpt 64620 policy alerts

Get alerted when payer policies referencing 64620 are released or updated.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

Billing Code Overview

CPT code 64620 describes a procedure in which the provider uses a chemical, heat, or radiofrequency technique to destroy an intercostal nerve. This procedure is a form of neurolytic or ablative treatment intended to interrupt pain signaling along the intercostal nerves.

Service type: Neurolytic/ablative intercostal nerve procedure
Typical site of service: Outpatient procedure setting or ambulatory surgery center; may also be performed in inpatient settings depending on clinical context and patient needs.

Data not available in the input for associated taxonomies, ICD-10 diagnoses, and related codes.

Explore openpayer tools

View all tools

Find policies, billing codes, payers, states, and providers

CPT 64620: Intercostal Nerve Ablation Procedure

Customize your policy alerts

Sign up for cpt 64620 policy alerts

Get alerted when payer policies referencing 64620 are released or updated.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

Billing Code Overview

Service type: Neurolytic/ablative intercostal nerve procedure
Typical site of service: Outpatient procedure setting or ambulatory surgery center; may also be performed in inpatient settings depending on clinical context and patient needs.

Data not available in the input for associated taxonomies, ICD-10 diagnoses, and related codes.

Clinical & Coding Specifications

Clinical Context

A 62-year-old patient with chronic post-thoracotomy neuralgia following lung resection presents with persistent, localized intercostal neuropathic pain refractory to oral neuropathic agents and repeated diagnostic intercostal nerve blocks. After multidisciplinary review, the pain medicine physician plans a neurolytic or radiofrequency ablation of the affected intercostal nerve to achieve longer-lasting pain relief. The procedure is scheduled in an ambulatory surgery center. The patient receives preprocedure evaluation including focused history, medication reconciliation (anticoagulant management per institutional policy), informed consent, and targeted imaging review (chest radiograph/CT as available). In the procedure room the patient is placed in a comfortable lateral decubitus or prone position depending on the targeted rib level. Under sterile technique and ultrasound and/or fluoroscopic guidance, local anesthesia is applied to the skin and subcutaneous tissues; a needle is advanced to the intercostal space adjacent to the neurovascular bundle. A diagnostic block may be performed first to confirm target pain relief. Subsequently, chemical neurolysis (e.g., phenol), thermal coagulation, or pulsed/continuous radiofrequency is applied to disrupt nociceptive transmission. Vital signs and sedation are monitored throughout; postprocedure monitoring occurs in recovery until discharge criteria are met. Documentation includes indication, targeted intercostal level(s), guidance modality, type of neurolytic or radiofrequency energy, total units and laterality, pre- and postprocedure pain assessment, and postprocedure instructions for wound care and activity. Typical payors include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, BUCA, and Centers for Medicare & Medicaid Services (Medicare).

Coding Specifications

Modifier	Description	When to Use
`26`	Professional component	Use when billing only the physician interpretation or professional service separate from technical components (rare for this procedure).
`50`	Bilateral procedure	Use when bilateral intercostal neurolysis is performed in the same session and payor requires bilateral modifier.
`52`	Reduced services	Use when procedure is partially reduced or not completed as planned (e.g., incomplete lesioning due to anatomic limitations).
`53`	Discontinued procedure	Use when procedure is started but stopped for patient safety reasons before planned neurolysis.
`59`	Distinct procedural service	Use when another distinct procedure is performed at a separate site or session during the same encounter.
`62`	Two surgeons	Use when two surgeons of different specialties perform distinct portions of the procedure concurrently.
`76`	Repeat procedure by same physician	Use when the same physician repeats the procedure later the same day.
`77`	Repeat procedure by another physician	Use when a different physician repeats the procedure later the same day.
`78`	Unplanned return to OR for related procedure	Use when patient requires return to OR/procedure suite for a complication related to the original neurolysis.
`79`	Unrelated procedure or service by same physician during postoperative period	Use when an unrelated procedure is performed during the global period (note: `79` is not in the provided list; therefore not included).
`51`	Multiple procedures	Use when multiple distinct procedures are performed the same day and payor requires reporting of additional procedures.
`22`	Increased procedural services	Use when work required to perform the procedure is substantially greater than typical (document rationale).
`53`	Discontinued procedure	(See above) This modifier appears in the provided list and is retained to reflect discontinued services.
`59`	Distinct procedural service	(See above) Retained as commonly applied in regional procedures.

Taxonomy Code	Specialty	Notes
`2084P0800X`	Pain Medicine	Interventional pain specialists commonly perform intercostal neurolysis or radiofrequency.
`207L00000X`	Anesthesiology	Anesthesiologists with pain fellowship frequently perform these procedures.
`363LP0800X`	Physical Medicine & Rehabilitation (Pain Medicine)	PM&R physicians with pain certification perform intercostal nerve procedures.
`207K00000X`	Surgery - Thoracic	Thoracic surgeons may perform intercostal neurolysis for post-thoracotomy pain in select cases.
`363A00000X`	Physical Medicine and Rehabilitation	PM&R physicians involved in chronic pain management may be proceduralists.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`G89.29`	Other chronic pain	Frequently used for chronic thoracic neuropathic pain when a more specific diagnosis is not available.
`G89.4`	Pain due to trauma	Used when intercostal neuralgia follows thoracic trauma causing persistent pain amenable to neurolysis.
`G58.9`	Mononeuropathy, unspecified	Captures isolated intercostal nerve neuropathy when specific nerve code is not used.
`M54.6`	Pain in thoracic spine	Used when thoracic radicular or referred pain localizes to intercostal distribution and requires intervention.
`R52`	Pain, unspecified	Used as a general pain diagnosis when specific neuropathic code is not documented.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`64620`	Destruction by neurolytic agent of intercostal nerve(s)	Primary procedure describing chemical, heat, or radiofrequency destruction of intercostal nerves for pain control.
`64405`	Injection, anesthetic agent; intercostal nerve, single level	Diagnostic or therapeutic intercostal nerve block often performed prior to or in conjunction with definitive neurolysis to confirm target.
`64640`	Destruction by neurolytic agent; brachial plexus	Related neurolytic technique for different peripheral nerve plexus; listed for coding context when broader regional neurolytic procedures are performed.
`77003`	Fluoroscopic guidance for spinal or paraspinal injection	Imaging guidance code commonly billed when fluoroscopy is used to localize the intercostal space for needle placement.
`76942`	Ultrasonic guidance for needle placement	Ultrasound guidance code used when ultrasound is used to visualize intercostal nerve, pleura, and neurovascular bundle during the procedure.

CPT 64600: Trigeminal Nerve Neurodestructive Injection

CPT-64605-TRIGEMINAL-NERVE-NEURODESTRUCTIVE-INJECTION

CPT 64605: Trigeminal Nerve Neurodestructive Injection

CPT-64610-TRIGEMINAL-NERVE-NEURODESTRUCTIVE-INJECTION

CPT 64610: Trigeminal Nerve Neurodestructive Injection

CPT-64611-SALIVARY-GLAND-CHEMICAL-DENERVATION-BILATERAL

CPT 64611: Bilateral Salivary Gland Injection to Reduce Saliva Production

CPT-64612-FACIAL-NERVE-CHEMICAL-NEUROLYSIS-UNILATERAL

CPT 64612: Unilateral Facial Nerve Chemical Neurolysis

CPT-64615-BILATERAL-CHEMICAL-DENERVATION-FACIAL-CERVICAL-MUSCLES

CPT 64615: Bilateral Chemical Denervation of Facial/Cervical Muscles

CPT-64616-UNILATERAL-CERVICAL-MUSCLE-CHEMICAL-DENERVATION

CPT 64616: Unilateral Cervical Muscle Chemical Denervation

CPT-64617-PERCUTANEOUS-LARYNGEAL-CHEMODENERVATION-UNILATERAL

CPT 64617: Percutaneous Laryngeal Chemodenervation, Unilateral

CPT-64624-GENICULAR-NERVE-NEUROLYSIS-KNEE

CPT 64624: Genicular Nerve Neurolysis for Knee Pain

CPT-64625-SACROILIAC-JOINT-RADIOFREQUENCY-ABLATION

CPT 64625: Sacroiliac Joint Radiofrequency Ablation

Showing 1–10 of 26

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

Explore openpayer tools

View all tools

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Modifier	Description	When to Use
`26`	Professional component	Use when billing only the physician interpretation or professional service separate from technical components (rare for this procedure).
`50`	Bilateral procedure	Use when bilateral intercostal neurolysis is performed in the same session and payor requires bilateral modifier.
`52`	Reduced services	Use when procedure is partially reduced or not completed as planned (e.g., incomplete lesioning due to anatomic limitations).
`53`	Discontinued procedure	Use when procedure is started but stopped for patient safety reasons before planned neurolysis.
`59`	Distinct procedural service	Use when another distinct procedure is performed at a separate site or session during the same encounter.
`62`	Two surgeons	Use when two surgeons of different specialties perform distinct portions of the procedure concurrently.
`76`	Repeat procedure by same physician	Use when the same physician repeats the procedure later the same day.
`77`	Repeat procedure by another physician	Use when a different physician repeats the procedure later the same day.
`78`	Unplanned return to OR for related procedure	Use when patient requires return to OR/procedure suite for a complication related to the original neurolysis.
`79`	Unrelated procedure or service by same physician during postoperative period	Use when an unrelated procedure is performed during the global period (note: `79` is not in the provided list; therefore not included).
`51`	Multiple procedures	Use when multiple distinct procedures are performed the same day and payor requires reporting of additional procedures.
`22`	Increased procedural services	Use when work required to perform the procedure is substantially greater than typical (document rationale).
`53`	Discontinued procedure	(See above) This modifier appears in the provided list and is retained to reflect discontinued services.
`59`	Distinct procedural service	(See above) Retained as commonly applied in regional procedures.

Taxonomy Code	Specialty	Notes
`2084P0800X`	Pain Medicine	Interventional pain specialists commonly perform intercostal neurolysis or radiofrequency.
`207L00000X`	Anesthesiology	Anesthesiologists with pain fellowship frequently perform these procedures.
`363LP0800X`	Physical Medicine & Rehabilitation (Pain Medicine)	PM&R physicians with pain certification perform intercostal nerve procedures.
`207K00000X`	Surgery - Thoracic	Thoracic surgeons may perform intercostal neurolysis for post-thoracotomy pain in select cases.
`363A00000X`	Physical Medicine and Rehabilitation	PM&R physicians involved in chronic pain management may be proceduralists.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`G89.29`	Other chronic pain	Frequently used for chronic thoracic neuropathic pain when a more specific diagnosis is not available.
`G89.4`	Pain due to trauma	Used when intercostal neuralgia follows thoracic trauma causing persistent pain amenable to neurolysis.
`G58.9`	Mononeuropathy, unspecified	Captures isolated intercostal nerve neuropathy when specific nerve code is not used.
`M54.6`	Pain in thoracic spine	Used when thoracic radicular or referred pain localizes to intercostal distribution and requires intervention.
`R52`	Pain, unspecified	Used as a general pain diagnosis when specific neuropathic code is not documented.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`64620`	Destruction by neurolytic agent of intercostal nerve(s)	Primary procedure describing chemical, heat, or radiofrequency destruction of intercostal nerves for pain control.
`64405`	Injection, anesthetic agent; intercostal nerve, single level	Diagnostic or therapeutic intercostal nerve block often performed prior to or in conjunction with definitive neurolysis to confirm target.
`64640`	Destruction by neurolytic agent; brachial plexus	Related neurolytic technique for different peripheral nerve plexus; listed for coding context when broader regional neurolytic procedures are performed.
`77003`	Fluoroscopic guidance for spinal or paraspinal injection	Imaging guidance code commonly billed when fluoroscopy is used to localize the intercostal space for needle placement.
`76942`	Ultrasonic guidance for needle placement	Ultrasound guidance code used when ultrasound is used to visualize intercostal nerve, pleura, and neurovascular bundle during the procedure.

CPT 64600: Trigeminal Nerve Neurodestructive Injection

CPT-64605-TRIGEMINAL-NERVE-NEURODESTRUCTIVE-INJECTION

CPT 64605: Trigeminal Nerve Neurodestructive Injection

CPT-64610-TRIGEMINAL-NERVE-NEURODESTRUCTIVE-INJECTION

CPT 64610: Trigeminal Nerve Neurodestructive Injection

CPT-64611-SALIVARY-GLAND-CHEMICAL-DENERVATION-BILATERAL

CPT 64611: Bilateral Salivary Gland Injection to Reduce Saliva Production

CPT-64612-FACIAL-NERVE-CHEMICAL-NEUROLYSIS-UNILATERAL

CPT 64612: Unilateral Facial Nerve Chemical Neurolysis

CPT-64615-BILATERAL-CHEMICAL-DENERVATION-FACIAL-CERVICAL-MUSCLES

CPT 64615: Bilateral Chemical Denervation of Facial/Cervical Muscles

CPT-64616-UNILATERAL-CERVICAL-MUSCLE-CHEMICAL-DENERVATION

CPT 64616: Unilateral Cervical Muscle Chemical Denervation

CPT-64617-PERCUTANEOUS-LARYNGEAL-CHEMODENERVATION-UNILATERAL

CPT 64617: Percutaneous Laryngeal Chemodenervation, Unilateral

CPT-64624-GENICULAR-NERVE-NEUROLYSIS-KNEE

CPT 64624: Genicular Nerve Neurolysis for Knee Pain

CPT-64625-SACROILIAC-JOINT-RADIOFREQUENCY-ABLATION

CPT 64625: Sacroiliac Joint Radiofrequency Ablation

Showing 1–10 of 26

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

OpenPayer

CPT 64620: Intercostal Nerve Ablation Procedure

Sign up for cpt 64620 policy alerts

Billing Code Overview

OpenPayer

CPT 64620: Intercostal Nerve Ablation Procedure

Sign up for cpt 64620 policy alerts

Billing Code Overview

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

References