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    v1.0.30
    OpenPayerBilling CodesDestruction Procedures on the PenisCPT cpt-54056-penile-lesion-cryotherapy-destruction-liquid-nitrogen
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    CPT 54056: Destruction of Penile Skin Lesion by Cryotherapy

    Medicare pays $149 on average nationally for this procedure.

    CPT code 54056 describes destruction of a skin lesion on the penis (examples include condyloma, papilloma, molluscum contagiosum, or herpetic vesicle) performed by application of liquid nitrogen to freeze and ablate the lesion; service type: lesion destruction/cryotherapy; typical site of service: outpatient clinic, dermatology or urology office, or ambulatory surgical setting for minor procedures.

    For related coverage guidance, see recent payer policy updates: Mohs Micrographic Surgery, Mohs Micrographic Surgery, Mohs Micrographic Surgery.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult male presenting to an outpatient urology or dermatology clinic with one or more symptomatic penile skin lesions, such as condyloma acuminata (anogenital warts), molluscum contagiosum, papillomas, or painful herpetic vesicles. The clinician performs a focused exam of the genitalia, documents lesion number, size, location, and symptoms (pain, bleeding, pruritus). After obtaining informed consent and ensuring no contraindications (extensive cryotherapy on mucosal surfaces, allergy to topical anesthetic if used), the provider isolates the lesion, cleans the area, and applies an appropriate cryogen (commonly liquid nitrogen) with a spray or cotton-tipped applicator until adequate freeze has been achieved. Post-procedure instructions include wound care, pain management, signs of infection, and return precautions. The patient may receive a topical analgesic or local anesthetic prior to treatment if needed. Follow-up is arranged based on response; additional treatments may be scheduled for persistent lesions. Typical sites of service include outpatient clinic or ambulatory surgery centers for multiple or extensive lesions. The service type is a minor cutaneous procedure/dermatologic treatment using destructive modality (cryotherapy) for lesion eradication and symptom relief.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    54050Destruction of lesion(s) of penis; simple (e.g., single lesion)Alternative code when procedure is described as simple destruction rather than specific cryotherapy technique; used for small/simple lesions.
    54055Destruction of lesion(s) of penis; extensive (>15 lesions or involving larger surface area)Used when multiple or extensive lesions require more extensive destruction techniques; may be used when higher complexity or larger area treated.
    11730Avulsion of nail plate, partial or complete, simple; singleNot commonly linked but included here for clinic procedures context where minor skin procedures may be billed alongside; bill separately if performed.
    99070Supplies and materials (e.g., liquid nitrogen canister) used for procedures, non-reimbursed itemsUse to report supplies when payer allows separate supply charges; often bundled by payers.
    99024Postoperative follow-up visit global period (by surgeon)Used to report routine postoperative follow-up during global period when applicable; documents follow-up care after lesion destruction.

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    25CPT modifier 25 indicates that on the same day as another procedure or service, the same physician or other qualified health care professional provided a significant, separately identifiable…- When to apply: Use modifier 25 only on an E/M code to indicate the same provider delivered a significant, separately identifiable E/M service on the same day as another procedure or service — i.e.,…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207R00000X
    363L00000X
    207K00000X
    261QR0400X
    163WX0002X
    133VN1005X
    101YS0200X
    152WC0802X

    Related Payer Policy Updates

    Specialty: Dermatology1 / 3

    10 rows

    PolicyPayerEffective Date
    Mohs Micrographic Surgerypremerabluecrossofwashington2027-02-05
    Mohs Micrographic Surgerypremerabluecrossofwashington2027-02-05
    Mohs Micrographic Surgerypremerabluecrossofwashington2027-02-05
    FilsuvezCigna2026-11-01
    Destruction of Pre-Malignant Skin LesionsAnthem2026-10-01
    Onychomycosis diagnostic testing and coverageOscar Health2026-10-01
    Treatment of Capillary Malformations (Port Wine Stains)universityofutahhealthplans2026-09-28
    AnzupgoCigna2026-09-15
    Hyperhidrosispriority_health_medicare2026-09-01
    Zevaskyn Coverage for Recessive Dystrophic Epidermolysis BullosaCigna2026-09-01

    Related Codes

    CPT-54050-CHEMICAL-DESTRUCTION-PENILE-SKIN-LESION

    CPT 54050: Chemical Destruction of Penile Skin Lesion

    CPT-54055-PENILE-LESION-DESTRUCTION-ELECTROSURGERY

    CPT 54055: Destruction of Skin Lesion of Penis

    CPT-54057-LASER-DESTRUCTION-PENILE-SKIN-LESION

    CPT 54057: Laser Destruction of Penile Skin Lesion

    CPT-54060-PENILE-SKIN-LESION-EXCISION-DESTRUCTION

    CPT 54060: Excision/Destruction of Skin Lesion of Penis

    CPT-54065-PENILE-LESION-DESTRUCTION

    CPT 54065: Destruction of Extensive Penile Skin Lesions

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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