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    v1.0.30
    OpenPayerBilling CodesDestruction Procedures on the PenisCPT cpt-54050-chemical-destruction-penile-skin-lesion
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    CPT 54050: Chemical Destruction of Penile Skin Lesion

    Medicare pays $151 on average nationally for this procedure.

    CPT code 54050 describes chemical destruction of a skin lesion on the penis (examples: condyloma, papilloma, molluscum contagiosum, herpetic vesicle) performed with a topical chemical agent to eradicate the lesion and relieve pain; service type: minor surgical/lesion destruction procedure; typical site of service: office or outpatient clinic where topical chemical application and brief procedural monitoring are provided.

    For related coverage guidance, see recent payer policy updates: Mohs Micrographic Surgery, Mohs Micrographic Surgery, Mohs Micrographic Surgery.

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    Clinical & Coding Specifications

    Clinical Context

    A 28-year-old male presents to a urology clinic with several small, raised, papillomatous lesions on the glans and shaft of the penis consistent with condyloma acuminata. The lesions cause intermittent pruritus and mild discomfort during sexual activity. The clinician performs a focused genital skin exam, documents lesion size, number, and location, obtains relevant sexual history and informed consent, and discusses treatment options. After topical anesthesia or no anesthesia depending on lesion sensitivity, the provider applies a chemical agent (for example, trichloroacetic acid) directly to each lesion to achieve chemical destruction. The procedure is billed using 54050 for chemical destruction of penile skin lesions. Post-procedure instructions are provided for wound care, pain control, and return precautions. Follow-up may be scheduled to assess lesion resolution and screen for sexually transmitted infections as indicated.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    54050Destruction of a skin lesion on the penis; local application of chemical agentPrimary procedure for chemical destruction of penile lesions.
    11100Biopsy of skin; single lesionPerformed when a suspicious penile lesion requires histologic diagnosis prior to or instead of chemical destruction.
    54060Destruction of lesion(s) of penis including topical application; other methods (electrosurgery, cryosurgery)Alternative destructive modalities; may be performed instead of 54050 depending on lesion type and provider preference.
    87070Culture, bacterial; genital (e.g., urethral/cervical)May be ordered to evaluate for concomitant bacterial infection depending on presentation.
    87081Chlamydia culture (not standard CPT; molecular testing codes vary)Diagnostic testing for STIs often performed in the same visit as lesion treatment.
    99070Supplies and materials (e.g., tincture of time, chemical agents)Used to report additional supplies needed for chemical destruction when payer allows separate supply charge.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208000000X
    207Q00000X
    163W00000X
    207L00000X
    3336M0002X
    2080H0002X
    2279H0200X
    175F00000X

    Related ICD-10-CM Codes

    29 rows

    ICD-10-CM CodeDescription
    A60.01Herpesviral infection of penis
    A60.02Herpesviral infection of other male genital organs
    A60.03Herpesviral cervicitis
    A60.9Anogenital herpesviral infection, unspecified
    A63.0Anogenital (venereal) warts
    B00.1Herpesviral vesicular dermatitis
    B00.2Herpesviral gingivostomatitis and pharyngotonsillitis
    B07.0Plantar wart
    B07.8Other viral warts
    B08.1Molluscum contagiosum

    Showing 1–10 of 29

    Related Payer Policy Updates

    Specialty: Dermatology1 / 3

    10 rows

    PolicyPayerEffective Date
    Mohs Micrographic Surgerypremerabluecrossofwashington2027-02-05
    Mohs Micrographic Surgerypremerabluecrossofwashington2027-02-05
    Mohs Micrographic Surgerypremerabluecrossofwashington2027-02-05
    FilsuvezCigna2026-11-01
    Destruction of Pre-Malignant Skin LesionsAnthem2026-10-01
    Onychomycosis diagnostic testing and coverageOscar Health2026-10-01
    Treatment of Capillary Malformations (Port Wine Stains)universityofutahhealthplans2026-09-28
    AnzupgoCigna2026-09-15
    Hyperhidrosispriority_health_medicare2026-09-01
    Zevaskyn Coverage for Recessive Dystrophic Epidermolysis BullosaCigna2026-09-01

    Related Codes

    CPT-54055-PENILE-LESION-DESTRUCTION-ELECTROSURGERY

    CPT 54055: Destruction of Skin Lesion of Penis

    CPT-54056-PENILE-LESION-CRYOTHERAPY-DESTRUCTION-LIQUID-NITROGEN

    CPT 54056: Destruction of Penile Skin Lesion by Cryotherapy

    CPT-54057-LASER-DESTRUCTION-PENILE-SKIN-LESION

    CPT 54057: Laser Destruction of Penile Skin Lesion

    CPT-54060-PENILE-SKIN-LESION-EXCISION-DESTRUCTION

    CPT 54060: Excision/Destruction of Skin Lesion of Penis

    CPT-54065-PENILE-LESION-DESTRUCTION

    CPT 54065: Destruction of Extensive Penile Skin Lesions

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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