CPT code 52649 represents holmium laser enucleation of the prostate (HoLEP) with mechanical morcellation, a minimally invasive surgical treatment for symptomatic benign prostatic hyperplasia (BPH). Nationwide, this code captures a procedure increasingly used for moderate to large prostate volumes because enucleation plus morcellation allows complete adenoma removal with durable symptom relief and reduced long‑term reintervention. The code matters for hospitals, ambulatory surgery centers, urology practices, and payers because it denotes a definitive surgical approach distinct from transurethral resection or ablative therapies.

Key payers covered in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find clinical context for when CPT code 52649 is reported, typical sites of service, and operational considerations tied to procedural complexity and equipment (holmium:YAG laser and morcellator). The publication provides benchmarks for utilization and payment where available, summarizes relevant policy themes affecting coverage and site‑of‑service decisions, and highlights coding considerations specific to enucleation with morcellation versus other prostate procedures. Data not available in the input will be identified as such.