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    OpenPayerBilling CodesVesical Neck and Prostate Surgical ProceduresCPT cpt-52597-robotic-waterjet-prostate-tissue-removal-through-urethra
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    CPT 52597: Robotic Transurethral Waterjet Prostate Resection

    Medicare pays $559 on average nationally for this procedure.

    CPT code 52597 describes robotic-assisted removal of prostate tissue using high-pressure waterjets delivered transurethrally, including preprocedural planning, ultrasound guidance, and intraoperative hemostasis; this is a minimally invasive urologic resection procedure typically performed in an operating room or ambulatory surgical center under anesthesia and may include concurrent procedures such as vasectomy, meatotomy, cystourethroscopy, urethral calibration/dilation, or internal urethrotomy if performed.

    For related coverage guidance, see recent payer policy updates: Surgical Procedures, Outpatient Surgical Procedures - Site of Service, Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in Adults.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 68-year-old male with symptomatic benign prostatic hyperplasia (BPH) presents with lower urinary tract symptoms (LUTS) including urinary frequency, nocturia, weak stream, and incomplete emptying refractory to medical therapy (alpha-blockers and 5-alpha-reductase inhibitors). After evaluation with history, physical exam including digital rectal exam, urinalysis, serum PSA, and transrectal or transabdominal ultrasound to estimate prostate volume, the urologist recommends a waterjet enucleation of prostate tissue using robotic assistance (52597) to relieve obstruction.

    The clinical workflow includes pre-procedure counseling and consent, preoperative labs and anesthesia assessment, intraoperative planning and ultrasound guidance to localize adenomatous tissue, robotic-assisted delivery of high-pressure waterjets transurethrally to enucleate obstructing tissue, concurrent cystourethroscopy to monitor the urethra and bladder, control of bleeding (hemostasis measures), retrieval of tissue fragments or evacuation, and placement of a urinary catheter for postoperative drainage. Postoperative care includes monitoring for bleeding, urinary retention, infection, catheter management, and follow-up to assess symptom improvement and pathology results if tissue was sent for analysis.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    52601Transurethral excision and reconstruction of prostate; simple prostatectomy, retropubic or suprapubicAlternative surgical approach for larger prostates when open or simple prostatectomy is indicated; may be considered if endoscopic approach is unsuitable.
    52647Transurethral electrosurgical resection of the prostate, including control of bleeding, complete (TURP)Common alternative endoscopic procedure for BPH; TURP may be performed when waterjet enucleation is not used.
    52000Cystourethroscopy, with or without irrigation and ureteral catheterization; diagnostic, with or without collection of specimen(s) by brushing or washingDiagnostic cystourethroscopy performed before or during the procedure to evaluate urethra and bladder; included when performed as part of 52597 per code description if documented.
    55700Biopsy, prostate; needle, single or multiple, any approachPerformed preoperatively if malignancy suspected or for concomitant cancer workup; tissue from enucleation may also be sent to pathology instead of needle biopsy.
    51701Measurement of post-void residual, bladder scan (non-invasive)Used in preoperative assessment of urinary retention and bladder function as part of the pre-procedural evaluation.
    52332Cystourethroscopy, with dilation of urethral stricture (internal urethrotomy)May be performed if urethral stricture is encountered and requires dilation or internal urethrotomy during the same operative session; described as included in 52597 when performed.

    Related Modifiers

    14 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…

    Showing 1–10 of 14

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208000000X
    207L00000X
    363A00000X
    193200000X
    103TP2700X
    204C00000X
    2471Q0001X
    207RS0012X

    Related Payer Policy Updates

    Specialty: General Surgery1 / 2

    10 rows

    PolicyPayerEffective Date
    Surgical ProceduresUnitedHealthcare2026-09-01
    Outpatient Surgical Procedures - Site of ServiceUnitedHealthcare2026-09-01
    Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Site of Service for Ambulatory Surgical Procedures (ASC Select)Premera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Outpatient Surgical Procedures - Site of Servicesierra health and life2026-08-01
    Medical Necessity Guidelines — Inpatient Surgical CareMass General Brigham Health Plan2026-08-01
    Ambulatory Surgery Center (ASC) - Site of Care PolicyKaiser Permanente2026-08-01

    Related Codes

    CPT-52400-CYSTOURETHROSCOPY-CYSTOSCOPE-BLADDER-INSPECTION

    CPT 52400: Diagnostic Cystourethroscopy

    CPT-52402-EJACULATORY-DUCT-ENDOSCOPIC-EXCISION-OR-INCISION

    CPT 52402: Cystoscopic Excision or Incision of Ejaculatory Duct

    CPT-52441-TRANSPROSTATIC-IMPLANT-PLACEMENT-CYSTOURETHROSCOPIC

    CPT 52441: Single Permanent Adjustable Transprostatic Implant

    CPT-52442-TRANSPROSTATIC-IMPLANT-ADD-ON-PLACEMENT

    CPT 52442: Placement of Additional Permanent Adjustable Transprostatic Implant

    CPT-52443-BALLOON-DILATION-AND-DRUG-COATED-BALLOON-PROSTATE

    CPT 52443: Cystoscopic Transurethral Prostate Drug Delivery

    CPT-52450-TRANSURETHRAL-PROSTATE-CAPSULOTOMY-ENDOSCOPIC-INCISION

    CPT 52450: Endoscopic Transurethral Prostate Capsulotomy

    CPT-52500-CYSTOURETHROSCOPY-TRANSURETHRAL-EXCISION-BLADDER-NECK

    CPT 52500: Transurethral Excision of Bladder Neck to Relieve Obstruction

    CPT-52601-TRANSURETHRAL-RESECTION-PROSTATE-TURP

    CPT 52601: Transurethral Resection of Prostate (Partial)

    CPT-52630-PROSTATE-RESECTION-RESIDUAL-TISSUE

    CPT 52630: Resection of Residual or Regrown Prostate Tissue

    CPT-52640-ENDOSCOPIC-REMOVAL-BLADDER-NECK-CONTRACTURE

    CPT 52640: Endoscopic Removal of Postoperative Bladder Neck Contracture

    Showing 1–10 of 13

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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