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    v1.0.28
    OpenPayerBilling CodesUreter and Pelvis Transurethral Surgical ProceduresCPT cpt-52355-ureteral-pelvic-tumor-resection-cystourethroscopy-ureteroscopy
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    CPT 52355: Cystourethroscopy with Ureteral/Pelvic Tumor Resection

    Medicare pays $416 on average nationally for this procedure.

    CPT code 52355 describes a cystourethroscopy with ureteroscopy and/or pyeloscopy during which a ureteral or renal pelvic tumor is identified and resected; this is an endoscopic surgical procedure performed via the urethra into the bladder and up the ureter/renal pelvis, categorized as an endoscopic tumor resection typically performed in an operating room or procedure suite (ambulatory surgical center or hospital outpatient setting).

    For related coverage guidance, see recent payer policy updates: Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use Disorders, Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use Disorders, Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use Disorders.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 68-year-old male presents with painless gross hematuria and intermittent flank pain. Imaging (CT urogram) demonstrates a filling defect in the distal ureter concerning for a ureteral tumor. The urologist schedules the patient for a diagnostic cystourethroscopy with ureteroscopy and planned endoscopic resection of the ureteral lesion. In the preoperative workflow, the patient undergoes urine culture and coagulation assessment; informed consent is obtained for cystoscopy, ureteroscopy, possible tumor resection, and stent placement. In the operating room or endoscopy suite under general or spinal anesthesia, a cystoscope is advanced via the urethra to inspect the urethra, prostatic urethra, and bladder. The ureteral orifice is identified, and a ureteroscope or flexible nephroscope is passed into the ureter and renal pelvis (pyeloscopy as needed). The lesion is visualized and resected or fulgurated endoscopically; tissue is sent for pathology. A ureteral stent may be placed for drainage. Postoperative workflow includes recovery, pathology review, and surveillance planning (imaging and cystoscopic follow-up). Typical site of service is an ambulatory surgery center or hospital outpatient department; inpatient admission may occur for complications or if combined with more extensive procedures. Service type: endoscopic urologic diagnostic and operative procedure (cystourethroscopy with ureteroscopy/pyeloscopy and tumor resection).

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    52000Cystourethroscopy, diagnostic, with or without collection of specimen(s) by brushing or washingPerformed when a diagnostic cystoscopy is done without ureteroscopy; often precedes or complements 52355 for bladder evaluation.
    53040Ureteroscopy, with or without irrigation, simpleMay be billed for diagnostic ureteroscopy without tumor resection; used when ureteroscopy is performed without endoscopic tumor removal.
    52356Cystourethroscopy, with ureteroscopy and/or pyeloscopy, with removal of ureteral stone(s) by ureteroscopy (with or without lithotripsy)Performed when ureteroscopy is used to remove stones rather than resect a tumor; alternative obstructive lesion management.
    50380Endoscopic resection of renal pelvic tumor (if applicable)Represents endoscopic management of a renal pelvic tumor; used when tumor is in pelvis and resected endoscopically.
    52204Cystourethroscopy with fulguration or resection of solid or papillary tumor of the bladder; single or multipleIf a concurrent bladder tumor is resected during the same session, this code describes bladder tumor resection and may be reported in addition to ureteral tumor resection when documentation supports multiple distinct anatomic sites.

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    25CPT modifier 25 indicates that on the same day as another procedure or service, the same physician or other qualified health care professional provided a significant, separately identifiable…- When to apply: Use modifier 25 only on an E/M code to indicate the same provider delivered a significant, separately identifiable E/M service on the same day as another procedure or service — i.e.,…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    2080P0206XPediatric Gastroenterology PhysicianA pediatrician who specializes in the diagnosis and treatment of diseases of the digestive systems of infants, children and adolescents. This speciali…
    208D00000XGeneral Practice PhysicianA physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
    207T00000XNeurological Surgery PhysicianA neurological surgeon provides the operative and non-operative management (i.e., prevention, diagnosis, evaluation, treatment, critical care, and reh…
    208600000XSurgery PhysicianA general surgeon has expertise related to the diagnosis - preoperative, operative and postoperative management - and management of complications of s…
    156FC0800XContact Lens Technician/TechnologistAn optician or other ancillary support staff person who, where authorized by state law and trained or certified to do so, may fit or dispense contact …
    111NI0900XInternist ChiropractorThe chiropractic internist may serve as a primary care physician or may see patients referred from other providers for evaluation and co-management. E…
    1744R1103XResearch Study Abstracter/CoderOther Service Providers · Specialist
    207VG0400XGynecology PhysicianA physician who specializes in diagnosis, treatment, and management of patients with gynecologic conditions.

    Related ICD-10-CM Codes

    28 rows

    ICD-10-CM CodeDescription
    C65.9Malignant neoplasm of unspecified renal pelvis
    C66.9Malignant neoplasm of unspecified ureter
    C67.2Malignant neoplasm of lateral wall of bladder
    C67.4Malignant neoplasm of posterior wall of bladder
    C67.7Malignant neoplasm of urachus
    C67.9Malignant neoplasm of bladder, unspecified
    D41.4Neoplasm of uncertain behavior of bladder
    N10Acute pyelonephritis
    N13.6Pyonephrosis
    N13.8Other obstructive and reflux uropathy

    Showing 1–10 of 28

    Related Payer Policy Updates

    Specialty: Anesthesiology1 / 3

    9 rows

    PolicyPayerEffective Date
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Elective Inpatient Services (for Idaho Only)UnitedHealthcare2026-06-01
    Sites of Servicepriority health2026-06-01
    Coverage for Ambulatory Surgery Unit (ASU)/Outpatient Facility and Anesthesia for Dental Servicesuniverahealthcare2026-05-21
    Mm_0579_Coveragepositioncriteria_Anesthesia_Services_Selected_Nerve_BlocksCigna2026-05-15
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric DisordersBlue Cross Blue Shield - North Carolina2026-04-01

    Related Codes

    CPT-52320-CYSTOURETHROSCOPY-URETERAL-STONE-REMOVAL

    CPT 52320: Cystourethroscopy with Ureteral Stone Removal

    CPT-52325-URETERAL-LITHOTRIPSY-CYSTOURETHROSCOPY

    CPT 52325: Cystourethroscopy with Ureteral Stone Fragmentation and Removal

    CPT-52327-CYSTOURETHROSCOPY-SUBURETERAL-IMPLANT-INJECTION-FOR-VUR

    CPT 52327: Cystourethroscopy with Ureteral Submucosal Injection

    CPT-52330-CYSTOURETHROSCOPY-URETERAL-STONE-MANIPULATION

    CPT 52330: Cystourethroscopy with Ureteral Stone Manipulation

    CPT-52332-CYSTOURETHROSCOPY-URETERAL-STENT-PLACEMENT

    CPT 52332: Cystourethroscopy with Ureteral Stent Placement

    CPT-52334-CYSTOURETHROSCOPY-PERCUTANEOUS-RETROGRADE-NEPHROSTOMY

    CPT 52334: Cystourethroscopy with Guidewire for Retrograde Nephrostomy

    CPT-52341-CYSTOURETHROSCOPY-URETERAL-STRICTURE-TREATMENT

    CPT 52341: Cystourethroscopy with Ureteral Stricture Treatment

    CPT-52342-CYSTOURETHROSCOPY-WITH-URETERAL-CATHETER-TO-UPJ-FOR-UPJ-STRICTURE-TREATMENT

    CPT 52342: Cystourethroscopy with Ureteral Catheterization and UPJ Stricture Treatment

    CPT-52343-CYSTOURETHROSCOPY-WITH-INTRARENAL-STRICTURE-TREATMENT

    CPT 52343: Cystourethroscopy with Intrarenal Stricture Treatment

    CPT-52344-CYSTOURETHROSCOPY-URETERAL-STRICTURE-TREATMENT-URETEROSCOPY

    CPT 52344: Cystourethroscopy with Ureteral Stricture Treatment and Ureteroscopy

    Showing 1–10 of 17

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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