CPT code 50080 denotes a percutaneous antegrade procedure to remove one or more stones from the kidney or renal pelvis using imaging guidance; it may include placement of a stent and nephrostomy tube and is described as a simple procedure. Nationally, this code captures a common urologic intervention for nephrolithiasis that has implications for facility resource use, imaging utilization, and postprocedure device management. Key payers addressed in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare.

Readers will find a concise overview of clinical context and procedural elements tied to CPT code 50080, payer coverage patterns and common modifiers, and benchmarking where available. The publication also summarizes coding nuances, expected sites of service (hospital OR or interventional radiology suite), and operational considerations such as typical adjuncts (stent and nephrostomy tube placement). Data not available in the input is noted where applicable. This resource is intended for coding, billing, and policy stakeholders seeking a national-level briefing on use and administrative handling of CPT code 50080.