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    v1.0.30
    OpenPayerBilling CodesIncision Procedures on the Abdomen, Peritoneum, and OmentumCPT cpt-49000-intra-abdominal-exploration-with-biopsy
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    CPT 49000: Exploratory Laparotomy with Diagnostic Biopsy

    Medicare pays $736 on average nationally for this procedure.

    CPT code 49000 describes an exploratory laparotomy in which the provider examines the abdominal cavity and the space between the abdominal wall and the peritoneal membrane to identify causes of abdominal pain, masses, suspected traumatic injury, or signs of infection and obtains tissue samples for laboratory analysis; this is a surgical diagnostic procedure typically performed in an operating room or surgical suite under appropriate anesthesia and includes inspection, palpation, and biopsy as indicated.

    For related coverage guidance, see recent payer policy updates: Ambulance and Medical Transport Services (Ground, Air and Water) Corporate Medical Policy, Emergency Air/Water Ambulance Services Medical Guideline, Non-Emergent Ambulance Services.

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    Clinical & Coding Specifications

    Clinical Context

    A 48-year-old patient presents to the emergency department with acute-onset severe lower abdominal pain, fever, and localized guarding. Initial evaluation with history, physical examination, laboratory studies, and abdominal ultrasound is inconclusive for the source of sepsis or an intra-abdominal mass. The surgical team recommends diagnostic open abdominal exploration with biopsy to identify intra-abdominal pathology. The patient is taken to the operating room, given general anesthesia, and a midline incision is made. The provider systematically examines the peritoneal cavity, inspects the small and large intestines, liver surface, omentum, and mesentery, and palpates for occult masses or sites of trauma. Any suspicious lesion or abnormal tissue is sampled and submitted as a biopsy to pathology. Intraoperative findings guide immediate management decisions (for example, drainage of abscess, resection of necrotic tissue, or staging of a suspected malignancy). The procedure is documented with indication, findings, tissue sampled, specimen labeling, and disposition of specimens to the laboratory. Typical workflow includes preoperative consent, perioperative antibiotics as indicated, operative dictation, and postoperative pathology correlation to guide definitive treatment planning.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    10120Incision and removal of foreign body, subcutaneous tissues; simpleMay be performed if a superficial foreign body is encountered and requires removal in the operative field.
    10180Incision and removal of foreign body, deep (e.g., in muscle or tendon sheath)Used when deeper retained foreign bodies are identified during exploration and require removal.
    38220Bone marrow biopsy, needle or trocarNot generally related; Data not available in the input.
    49002Diagnostic abdominal paracentesis (peritoneal tap)May be performed preoperatively or intraoperatively to obtain ascitic fluid for analysis when fluid is present.
    49010Paracentesis, diagnostic; with imaging guidanceUsed when image guidance is required to safely obtain peritoneal fluid prior to or during operative evaluation.

    Related Modifiers

    10 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    63Modifier‑63 is appended to surgical CPT codes (20000–69990) when a procedure is performed on a neonate or infant weighing ≤ 4 kg (about 8.8 lbs). The AMA/AAPC definition specifies this use and notes…- Use modifier -63 only for surgical procedures in the CPT 20000–69990 series performed on a neonate or infant who weighs ≤ 4 kg at the time of the procedure; it indicates increased complexity due to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…
    24Modifier 24 denotes an unrelated evaluation and management (E/M) service performed by the same physician or qualified healthcare professional during a postoperative global period. Per CPT guidance,…- Use modifier 24 when you report an evaluation and management (E/M) service performed by the same physician or same-specialty group during a procedure’s postoperative global period that is unrelated…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208800000X
    207L00000X
    207K00000X
    193200000X
    2086S0122X
    103TC1900X
    310500000X
    261QP2300X

    Related Payer Policy Updates

    Specialty: Emergency & Medical Transportation1 / 3

    10 rows

    PolicyPayerEffective Date
    Ambulance and Medical Transport Services (Ground, Air and Water) Corporate Medical Policybcbsvermont2026-10-01
    Emergency Air/Water Ambulance Services Medical GuidelineWPS Health Insurance2026-10-01
    Non-Emergent Ambulance ServicesConnectiCare2026-09-11
    Fixed Wing Air Ambulance TransportCigna2026-08-15
    Air AmbulanceAmbetter Georgia2026-08-01
    Ambulance Services (for Tennessee Only)UnitedHealthcare2026-08-01
    Ambulance Services (for New Mexico Only)UnitedHealthcare2026-08-01
    Air AmbulanceCentene2026-08-01
    Clinical Policy: Air AmbulanceAmbetter Nevada2026-08-01
    Clinical Policy: Air AmbulanceArizona Complete Health2026-08-01

    Related Codes

    CPT-49002-EXPLORATORY-REOPENING-OF-ABDOMINAL-INCISION

    CPT 49002: Exploration of Abdominal Incision for Complications

    CPT-49010-RETROPERITONEAL-EXPLORATION-WITH-BIOPSY

    CPT 49010: Retroperitoneal Exploration with Biopsy

    CPT-49013-PELVIC-PREPERITONEAL-PACKING-FOR-HEMORRHAGE-CONTROL

    CPT 49013: Pelvic Cavity Packing for Hemorrhage Control

    CPT-49014-PELVIC-CAVITY-REOPENING-AND-REMOVAL-OF-PACKING

    CPT 49014: Reopen Pelvic Cavity, Remove Preperitoneal Packing

    CPT-49020-OPEN-INCISION-DRAINAGE-INTRA-ABDOMINAL-ABSCESS

    CPT 49020: Incision and Drainage of Peritoneal Abscess, Open

    CPT-49040-SUBDIAPHRAGMATIC-ABSCESS-INCISION-AND-DRAINAGE

    CPT 49040: Incision and Drainage of Subdiaphragmatic Abscess

    CPT-49060-RETROPERITONEAL-ABSCESS-DRAINAGE-OPEN

    CPT 49060: Retroperitoneal Abscess Incision and Drainage

    CPT-49062-EXTRAPERITONEAL-LYMPHATIC-FLUID-DRAINAGE

    CPT 49062: Drainage of Extraperitoneal Lymphatic Collection

    CPT-49082-ABDOMINAL-PARACENTESIS-WITHOUT-IMAGING

    CPT 49082: Paracentesis, abdominal, without imaging

    CPT-49083-IMAGE-GUIDED-ABDOMINAL-PARACENTESIS

    CPT 49083: Imaging-Guided Abdominal Paracentesis

    Showing 1–10 of 11

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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