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    v1.0.30
    OpenPayerBilling CodesPancreas Transplantation ProceduresCPT cpt-48554-pancreas-allograft-implantation-extracorporeal-donor
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    CPT 48554: Cadaveric Pancreas Implantation, Native Pancreas Retained

    Medicare pays $2596 on average nationally for this procedure.

    CPT code 48554 describes the surgical implantation of a healthy pancreas harvested from a cadaveric donor into a patient with pancreatic failure, leaving the patient’s native pancreas in place; this is an organ transplant surgical service typically performed in an inpatient hospital operating room setting for patients requiring replacement of pancreatic function due to traumatic injury or chronic pancreatic disease.

    For related coverage guidance, see recent payer policy updates: Dental Anesthesia Services, Anesthesia Services for Interventional Pain Management Procedures in an Adult, General Anesthesia and Conscious Sedation Services.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult with end-stage pancreatic insufficiency or traumatic pancreatic destruction who receives a whole-organ pancreatic allograft from a deceased donor while retaining their native pancreas. The patient often has brittle diabetes with recurrent hypoglycemia or life-threatening metabolic complications, chronic pancreatitis with intractable pain and malabsorption, or major pancreatic trauma. The clinical workflow begins with multidisciplinary evaluation by transplant surgery, endocrinology, and transplant nephrology when applicable; listing and donor matching; preoperative optimization including immunologic workup and infection screening; operative implantation of the cadaveric pancreas with vascular anastomoses and enteric or bladder drainage of the exocrine secretions; and immediate postoperative management in a transplant-capable intensive care unit with immunosuppression initiation, glycemic monitoring, infection surveillance, and complication management (bleeding, thrombosis, graft pancreatitis, or rejection). Hospital inpatient stay is typical, often with staged follow-up in transplant clinics for dose adjustments and surveillance biopsies or imaging if rejection or graft dysfunction is suspected.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    48554Pancreas transplant with recipient pancreas left in place (implantation of a healthy cadaveric pancreas)Primary procedural code for isolated pancreas implantation; used for billing the transplant operation.
    44145Small intestine resection, partial; single resection and anastomosisMay be used if bowel resection and anastomosis are required during implantation or management of complications.
    47562Laparoscopy, surgical; cholecystectomy with cholangiographyCholecystectomy may be performed concurrently in selected patients during abdominal transplant surgery.
    36556Insertion of non-tunneled centrally inserted central venous catheter; age 5 years or olderCommonly performed pre- or intraoperatively for central venous access for fluids, immunosuppression, or hemodynamic monitoring.
    36415Collection of venous blood by venipunctureRoutine perioperative and postoperative laboratory monitoring for graft function and immunosuppressive drug levels.
    87810Infectious agent antigen detection (e.g., transplant donor/recipient infectious disease testing)Used for perioperative infectious disease testing as part of transplant evaluation and donor screening.

    Related Modifiers

    12 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    63Modifier‑63 is appended to surgical CPT codes (20000–69990) when a procedure is performed on a neonate or infant weighing ≤ 4 kg (about 8.8 lbs). The AMA/AAPC definition specifies this use and notes…- Use modifier -63 only for surgical procedures in the CPT 20000–69990 series performed on a neonate or infant who weighs ≤ 4 kg at the time of the procedure; it indicates increased complexity due to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Showing 1–10 of 12

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208000000X
    207L00000X
    207RH0000X
    207Q00000X
    208100000X
    163WN0003X
    222Q00000X
    2278G0305X

    Related ICD-10-CM Codes

    22 rows

    ICD-10-CM CodeDescription
    E08.9Diabetes mellitus due to underlying condition without complications
    E10.65Type 1 diabetes mellitus with hyperglycemia
    E10.9Type 1 diabetes mellitus without complications
    E11.65Type 2 diabetes mellitus with hyperglycemia
    E11.9Type 2 diabetes mellitus without complications
    E13.9Other specified diabetes mellitus without complications
    E89.1Postprocedural hypoinsulinemia
    K75.0Abscess of liver
    K86.0Alcohol-induced chronic pancreatitis
    K86.1Other chronic pancreatitis

    Showing 1–10 of 22

    Related Payer Policy Updates

    Specialty: Anesthesiology1 / 3

    10 rows

    PolicyPayerEffective Date
    Dental Anesthesia ServicesProvidence Health Plan2026-10-01
    Anesthesia Services for Interventional Pain Management Procedures in an AdultCigna2026-09-15
    General Anesthesia and Conscious Sedation ServicesUnitedHealthcare2026-09-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Elective Inpatient Services (for Idaho Only)UnitedHealthcare2026-06-01
    Sites of Servicepriority health2026-06-01
    Coverage for Ambulatory Surgery Unit (ASU)/Outpatient Facility and Anesthesia for Dental Servicesuniverahealthcare2026-05-21

    Related Codes

    CPT-48550-PANCREAS-PROCUREMENT-DONOR-ORGAN-RECOVERY

    CPT 48550: Pancreas Retrieval from Deceased Donor

    CPT-48551-PANCREAS-DONOR-PREPARATION-FOR-TRANSPLANTATION

    CPT 48551: Pancreas Preparation from Deceased Donor for Transplant

    CPT-48552-DONOR-PANCREAS-VEIN-RECONSTRUCTION-ORGAN-PREPARATION

    CPT 48552: Pancreas Vein Reconstruction for Donor Organ Preparation

    CPT-48556-DONOR-PANCREAS-EXPLANTATION

    CPT 48556: Explantation of Transplanted Pancreas

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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