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    v1.0.30
    OpenPayerBilling CodesDestruction Procedures on the AnusCPT cpt-46916-anal-lesion-destruction-cryotherapy
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    CPT 46916: Destruction of Anal Lesion by Cryotherapy

    Medicare pays $264 on average nationally for this procedure.

    CPT code 46916 describes destruction of an anal lesion (for example, condyloma, papilloma, molluscum contagiosum, or herpetic vesicle) using cryogenic agents such as liquid nitrogen or carbon dioxide; service type: lesion destruction by cryotherapy; typical site of service: outpatient clinic or office procedural setting focused on anorectal/dermatologic procedures.

    For related coverage guidance, see recent payer policy updates: Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disorders, Esophagogastroduodenoscopy (EGD) Coverage Policy, Radiofrequency Therapy for Fecal Incontinence.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult presenting to an outpatient dermatology or colorectal clinic with one or more small, localized anal lesions suspected clinically to be condyloma acuminata (anogenital warts), molluscum contagiosum, benign papilloma, or a herpetic vesicle. The patient history often includes itching, irritation, bleeding with defecation, or visible papules at the anal verge. Examination by the provider confirms a discrete lesion(s) appropriate for topical destruction.

    The clinical workflow begins with history and focused anorectal/skin examination, documentation of lesion size, number, and location, and informed consent for liquid nitrogen (cryotherapy) or other cold-destructive modalities. The provider isolates and visualizes the lesion using appropriate lighting and, if needed, an anoscope for deeper lesions. Lesions are treated with controlled applications of liquid nitrogen spray or cryoprobe; duration and freeze–thaw cycles are documented. Post-procedure instructions address pain control, wound care, signs of infection, and follow-up for recurrence or additional treatments. Procedures are typically performed in an outpatient office or ambulatory surgery setting under local anesthesia only when indicated. Billing uses surgical code 46916 for destruction of an anal lesion by cryotherapy.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    11100Biopsy of single lesion, skin, subcutaneous tissue and/or mucous membrane (simple)Performed when diagnostic confirmation of an anal lesion is required prior to or instead of destruction.
    46600Excision of lesion(s) of anal canal (simple)Used when lesion requires surgical excision rather than destructive therapy; may follow failed cryotherapy.
    45330Anoscopy; diagnostic, without interventionUsed to visualize anal canal lesions prior to cryotherapy for deeper or less visible lesions.
    99024Postoperative follow-up visit global period excludedUsed for post-procedure wound check when payer requires separate reporting (varies by payer policy).
    17000Destruction (eg, laser surgery, electrosurgery, cryosurgery, chemical agent) of benign lesions, up to 14 lesionsUsed for multiple superficial cutaneous lesions at other body sites; documents scope when multiple lesions are treated but not specific to anal canal.

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    25CPT modifier 25 indicates that on the same day as another procedure or service, the same physician or other qualified health care professional provided a significant, separately identifiable…- When to apply: Use modifier 25 only on an E/M code to indicate the same provider delivered a significant, separately identifiable E/M service on the same day as another procedure or service — i.e.,…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207P00000X
    207RH0000X
    2086S0102X
    208D00000X
    363A00000X
    207UN0901X
    163WX0003X
    2080P1004X

    Related ICD-10-CM Codes

    24 rows

    ICD-10-CM CodeDescription
    A60.9Anogenital herpesviral infection, unspecified
    A63.0Anogenital (venereal) warts
    A64Unspecified sexually transmitted disease
    B07.9Viral wart, unspecified
    B08.1Molluscum contagiosum
    B08.4Enteroviral vesicular stomatitis with exanthem
    D21.9Benign neoplasm of connective and other soft tissue, unspecified
    D23.9Other benign neoplasm of skin, unspecified
    K62.4Stenosis of anus and rectum
    K62.5Hemorrhage of anus and rectum

    Showing 1–10 of 24

    Related Payer Policy Updates

    Specialty: Gastroenterology1 / 3

    10 rows

    PolicyPayerEffective Date
    Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disordersbcbsvermont2026-12-01
    Esophagogastroduodenoscopy (EGD) Coverage Policyevicore2026-11-05
    Radiofrequency Therapy for Fecal IncontinenceCigna2026-10-15
    Magnetic Sphincter Augmentation for the Treatment of Gastroesophageal Reflux Disease (GERD)univerahealthcare2026-10-15
    High-Resolution Anoscopy (HRA)Premera Bluecross2026-10-01
    Gastroesophageal and Gastrointestinal (GI) Services and ProceduresColorado Rocky Mountain Health Plans2026-10-01
    Fecal Analysis in the Diagnosis of Intestinal Dysbiosis and Fecal Microbiota Transplant TestingOscar Health2026-10-01
    Serum Testing for Hepatic Fibrosis in the Evaluation and Monitoring of Chronic Liver DiseaseOscar Health2026-10-01
    Pancreatic Enzyme Testing for Acute PancreatitisOscar Health2026-10-01
    Helicobacter pylori TestingOscar Health2026-10-01

    Related Codes

    CPT-46900-CHEMICAL-DESTRUCTION-ANAL-LESION

    CPT 46900: Chemical Destruction of Anal Lesion

    CPT-46910-ANAL-LESION-DESTRUCTION-CAUTERY

    CPT 46910: Destruction of Anal Lesion by Electrocautery

    CPT-46917-ANAL-LESION-DESTRUCTION-LASER

    CPT 46917: Laser Destruction of Anal Lesion

    CPT-46922-ANAL-LESION-DESTRUCTION-EXCISION

    CPT 46922: Anal Lesion Destruction by Excision

    CPT-46924-EXTENSIVE-ANAL-LESION-DESTRUCTION

    CPT 46924: Extensive Destruction of Anal Lesion

    CPT-46930-INTERNAL-HEMORRHOID-THERMAL-DESTRUCTION

    CPT 46930: Destruction of Internal Hemorrhoids by Thermal Techniques

    CPT-46940-ANAL-FISSURE-OTOMY-AND-SPHINCTER-DILATION

    CPT 46940: Anal Fissure Excision with Anal Sphincter Dilation

    CPT-46942-ANAL-FISSURE-DEBRIDEMENT-AND-SPHINCTER-DILATION-SUBSEQUENT

    CPT 46942: Anal Fissure Excision/Scraping with Sphincter Dilation, Subsequent

    CPT-46945-HEMORRHOIDECTOMY-SINGLE-HEMORRHOID-EXCISION-NON-RUBBER-BAND

    CPT 46945: Hemorrhoidectomy, Single Hemorrhoid (Non-Band Technique)

    CPT-46946-EXCISION-MULTIPLE-HEMORRHOIDS-NON-RUBBER-BAND-TECHNIQUES

    CPT 46946: Hemorrhoidectomy, Two or More (Non-Rubber Band)

    Showing 1–10 of 12

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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