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    v1.0.30
    OpenPayerBilling CodesEndoscopy Procedures on the AnusCPT cpt-46607-anoscopy-with-magnification-chemical-enhancement-biopsy
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    CPT 46607: Anoscopy with High-Resolution Magnification and Biopsy

    Medicare pays $239 on average nationally for this procedure.

    CPT code 46607 describes an anoscopy procedure with high-resolution magnification and chemical enhancement to examine the anus and obtain one or more tissue biopsies; service type: anoscopy with biopsy, performed in an outpatient clinic, office, or ambulatory surgical setting where anoscopic visualization and specimen collection are feasible.

    For related coverage guidance, see recent payer policy updates: Surgical Procedures, Outpatient Surgical Procedures - Site of Service, Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in Adults.

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    Table of contents

    Progress1 / 7

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    Clinical & Coding Specifications

    Clinical Context

    A 52-year-old patient presents to a colorectal clinic with a 3-week history of rectal bleeding and intermittent anal pain. Physical exam reveals a suspicious-appearing lesion at the anal verge. The clinician performs an office-based anoscopy using a small tubular anoscope with high-resolution magnification and applies a chemical contrast agent to enhance mucosal visualization. Targeted biopsies of the abnormal tissue are taken for histopathology to evaluate for dysplasia, neoplasm, or inflammatory disease. Specimens are labeled and sent to pathology with contemporaneous documentation of site, number of biopsies, and any immediate complications. Typical workflow includes pre-procedure informed consent, focused history and medications (including anticoagulants), positioning and preparation in an outpatient exam room or minor procedure suite, local anesthetic as indicated, anoscopic visualization with enhancement, biopsy collection, hemostasis, brief recovery and post-procedure instructions, and documentation of specimen handling and procedural findings.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    45330Flexible sigmoidoscopy, diagnostic; with biopsy, single or multiplePerformed when lesions extend beyond the anal canal or to evaluate distal rectum; may be performed before or after anoscopic biopsy.
    46500Anoscopy; diagnostic, without biopsyRepresents the diagnostic anoscopic exam when no biopsy is taken; 46607 is reported instead when biopsy is performed with enhanced visualization.
    46900Excision of anal lesion (eg, papilloma, polyp, or condyloma); simplePerformed when an identified lesion requires excision rather than or in addition to biopsy.
    44180Exploratory laparotomy, exploratory abdominal procedure (limited)Rarely related; included only when an extended abdominal-pelvic surgical exploration is required for advanced disease following diagnostic biopsies.
    88305Pathology, surgical pathology, gross and microscopic examination, level IVTypical pathologic billing code for a biopsy specimen submitted after 46607 to evaluate tissue histology.

    Related Modifiers

    12 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    25CPT modifier 25 indicates that on the same day as another procedure or service, the same physician or other qualified health care professional provided a significant, separately identifiable…- When to apply: Use modifier 25 only on an E/M code to indicate the same provider delivered a significant, separately identifiable E/M service on the same day as another procedure or service — i.e.,…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…

    Showing 1–10 of 12

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207P00000X
    207Q00000X
    208D00000X
    163W00000X
    207L00000X
    207RP1001X
    207ZI0100X
    276400000X

    Related ICD-10-CM Codes

    26 rows

    ICD-10-CM CodeDescription
    A63.8Other specified predominantly sexually transmitted diseases
    B07.9Viral wart, unspecified
    B35.6Tinea cruris
    C21.0Malignant neoplasm of anus, unspecified
    C21.1Malignant neoplasm of anal canal
    C21.2Malignant neoplasm of cloacogenic zone
    C21.8Malignant neoplasm of overlapping sites of rectum, anus and anal canal
    K51.90Ulcerative colitis, unspecified, without complications
    K51.912Ulcerative colitis, unspecified with intestinal obstruction
    K51.913Ulcerative colitis, unspecified with fistula

    Showing 1–10 of 26

    Related Payer Policy Updates

    Specialty: General Surgery1 / 3

    10 rows

    PolicyPayerEffective Date
    Surgical ProceduresUnitedHealthcare2026-09-01
    Outpatient Surgical Procedures - Site of ServiceUnitedHealthcare2026-09-01
    Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Site of Service for Ambulatory Surgical Procedures (ASC Select)Premera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Outpatient Surgical Procedures - Site of Servicesierra health and life2026-08-01
    Medical Necessity Guidelines — Inpatient Surgical CareMass General Brigham Health Plan2026-08-01
    Ambulatory Surgery Center (ASC) - Site of Care PolicyKaiser Permanente2026-08-01

    Related Codes

    CPT-46600-ANOSCOPY-WITH-ANAL-CANAL-SAMPLING

    CPT 46600: Anoscopy with Anal Canal Specimen Collection

    CPT-46601-DIAGNOSTIC-ANOSCOPY-ENHANCED-VISUALIZATION

    CPT 46601: Diagnostic Anoscopy with Enhanced Visualization

    CPT-46604-ANOSCOPY-WITH-ANAL-DILATION

    CPT 46604: Anoscopy with Anal Dilation

    CPT-46606-ANOSCOPY-WITH-BIOPSY

    CPT 46606: Anoscopy with Biopsy, Anal Canal Tissue Sampling

    CPT-46608-ANOSCOPY-WITH-ANAL-FOREIGN-BODY-REMOVAL

    CPT 46608: Anoscopy with Removal of Anal Foreign Body

    CPT-46610-ANOSCOPY-SINGLE-LESION-REMOVAL-HOT-BIOPSY-BIPOLAR-CAUTERY

    CPT 46610: Anoscopy with Removal of Single Lesion

    CPT-46611-ANOSCOPY-SNARE-POLYPECTOMY

    CPT 46611: Anoscopy with Removal of Single Polyp/Tumor

    CPT-46612-ANOSCOPY-MULTIPLE-LESION-REMOVAL

    CPT 46612: Anoscopy with Removal of Multiple Lesions

    CPT-46614-ANOSCOPY-WITH-HEMOSTASIS

    CPT 46614: Anoscopy with Control of Bleeding

    CPT-46615-ANOSCOPY-LESION-EXCISION

    CPT 46615: Anoscopy with Excision of Anorectal Lesion

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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