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    v1.0.30
    OpenPayerBilling CodesEndoscopy Procedures on the AnusCPT cpt-46606-anoscopy-with-biopsy
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    CPT 46606: Anoscopy with Biopsy, Anal Canal Tissue Sampling

    Medicare pays $320 on average nationally for this procedure.

    CPT code 46606 describes an anoscopy with biopsy, a diagnostic procedure in which a provider uses a small rigid anoscope to visually examine the anal canal and obtain tissue samples for histologic evaluation; the service type is an anoscopic diagnostic procedure with tissue sampling and the typical site of service is an outpatient clinic, office, or ambulatory surgery center where minor anorectal procedures are performed.

    For related coverage guidance, see recent payer policy updates: Surgical Procedures, Outpatient Surgical Procedures - Site of Service, Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in Adults.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 54-year-old patient presents to an outpatient colorectal clinic with rectal bleeding and intermittent anal pain. After history and physical exam, the colorectal specialist recommends an anoscopy with biopsy to evaluate for hemorrhoids, anal fissure, suspicious lesions, or other mucosal pathology. The procedure is performed in an ambulatory surgery center or office procedure room under local anesthesia or topical anesthetic. The provider inserts a rigid anoscope to visualize the distal anal canal and distal rectum, documents findings (eg, internal hemorrhoids, ulceration, mass, area of erythema), and obtains targeted mucosal biopsies using forceps for histopathology.

    Clinical workflow steps:

    • Referral or presentation for rectal bleeding, anal pain, change in bowel habits, or follow-up of known anal lesions.

    • Pre-procedure evaluation including brief focused history, medication review (anticoagulants, antiplatelets), and informed consent.

    • Positioning (left lateral decubitus), application of topical anesthetic and lubrication, anoscopic inspection.

    • Direct visualization of the anal canal and distal rectum with the rigid anoscope; targeted biopsies obtained and placed in pathology containers.

    • Procedure note documents indication, findings, number/location of biopsies, specimen handling, estimated blood loss if applicable, and level of anesthesia.

    • Post-procedure instructions provided; specimens sent to pathology with appropriate clinical history.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    46900Hemorrhoidectomy, internal and external; with device (eg, stapling)Definitive surgical treatment for symptomatic hemorrhoids identified on anoscopy; may follow anoscopic diagnosis.
    46221Excision, internal hemorrhoid(s), single column, including tie, any method; 1st columnAlternative procedural treatment for internal hemorrhoids diagnosed by anoscopy.
    45378Colonoscopy, flexible; diagnostic, including collection of specimen(s) by brushing or washing, when performed (separate procedure)Performed when deeper colonic evaluation is indicated after abnormal anoscopic findings or ongoing bleeding.
    88305Surgical pathology, gross and microscopic examination, intermediate complexityPathology CPT for interpretation of biopsy specimens obtained during anoscopy.
    45330Flexible sigmoidoscopy, diagnostic; with biopsy, single or multiplePerformed when evaluation of sigmoid colon/rectum beyond the anoscope is needed after anoscopic findings.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RH0000X
    207X00000X
    207K00000X
    2080P0207X
    207L00000X
    364SI0800X
    174400000X
    246ZA2600X

    Related ICD-10-CM Codes

    21 rows

    ICD-10-CM CodeDescription
    B37.5Candidal meningitis
    D01.0Carcinoma in situ of colon
    D07.5Carcinoma in situ of prostate
    K52.9Noninfective gastroenteritis and colitis, unspecified
    K57.20Diverticulitis of large intestine with perforation and abscess without bleeding
    K57.30Diverticulosis of large intestine without perforation or abscess without bleeding
    K58.9Irritable bowel syndrome, unspecified
    K60.0Acute anal fissure
    K60.1Chronic anal fissure
    K60.2Anal fissure, unspecified

    Showing 1–10 of 21

    Related Payer Policy Updates

    Specialty: General Surgery1 / 3

    10 rows

    PolicyPayerEffective Date
    Surgical ProceduresUnitedHealthcare2026-09-01
    Outpatient Surgical Procedures - Site of ServiceUnitedHealthcare2026-09-01
    Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Site of Service for Ambulatory Surgical Procedures (ASC Select)Premera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Outpatient Surgical Procedures - Site of Servicesierra health and life2026-08-01
    Medical Necessity Guidelines — Inpatient Surgical CareMass General Brigham Health Plan2026-08-01
    Ambulatory Surgery Center (ASC) - Site of Care PolicyKaiser Permanente2026-08-01

    Related Codes

    CPT-46600-ANOSCOPY-WITH-ANAL-CANAL-SAMPLING

    CPT 46600: Anoscopy with Anal Canal Specimen Collection

    CPT-46601-DIAGNOSTIC-ANOSCOPY-ENHANCED-VISUALIZATION

    CPT 46601: Diagnostic Anoscopy with Enhanced Visualization

    CPT-46604-ANOSCOPY-WITH-ANAL-DILATION

    CPT 46604: Anoscopy with Anal Dilation

    CPT-46607-ANOSCOPY-WITH-MAGNIFICATION-CHEMICAL-ENHANCEMENT-BIOPSY

    CPT 46607: Anoscopy with High-Resolution Magnification and Biopsy

    CPT-46608-ANOSCOPY-WITH-ANAL-FOREIGN-BODY-REMOVAL

    CPT 46608: Anoscopy with Removal of Anal Foreign Body

    CPT-46610-ANOSCOPY-SINGLE-LESION-REMOVAL-HOT-BIOPSY-BIPOLAR-CAUTERY

    CPT 46610: Anoscopy with Removal of Single Lesion

    CPT-46611-ANOSCOPY-SNARE-POLYPECTOMY

    CPT 46611: Anoscopy with Removal of Single Polyp/Tumor

    CPT-46612-ANOSCOPY-MULTIPLE-LESION-REMOVAL

    CPT 46612: Anoscopy with Removal of Multiple Lesions

    CPT-46614-ANOSCOPY-WITH-HEMOSTASIS

    CPT 46614: Anoscopy with Control of Bleeding

    CPT-46615-ANOSCOPY-LESION-EXCISION

    CPT 46615: Anoscopy with Excision of Anorectal Lesion

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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