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    v1.0.30
    OpenPayerBilling CodesOther Procedures on the Intestines (Except Rectum)CPT cpt-44721-small-intestine-preparation-artery-anastomosis
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    CPT 44721: Preparation of Previously Harvested Small Intestine

    Medicare pays $344 on average nationally for this procedure.

    CPT code 44721 describes the surgical service in which the provider examines and prepares previously harvested small intestine tissue, including preparation of the artery for anastomosis; this procedure is a surgical graft/preparation service typically performed in an operating room or other surgical suite setting and involves meticulous vascular and bowel tissue preparation prior to implantation or anastomotic reconstruction.

    For related coverage guidance, see recent payer policy updates: Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disorders, Esophagogastroduodenoscopy (EGD) Coverage Policy, Radiofrequency Therapy for Fecal Incontinence.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a 45–65-year-old adult undergoing intestinal transplantation or a planned reconstruction using a previously harvested segment of small intestine. The clinical workflow begins in the operating room after procurement of the donor intestinal graft. The transplant surgeon inspects and prepares the harvested small intestine on the back table: trimming the bowel, irrigating the lumen, evaluating viability of the segment, and carefully dissecting and preparing the mesenteric artery and its arterial stump for microvascular or standard anastomosis to the recipient arterial inflow. Hemostasis is confirmed and sizing of the arterial ends is performed to match recipient vessels. The prepared graft is then transferred to the recipient surgical field for vascular and enteric anastomoses. Typical perioperative team members include the transplant surgeon, assistant surgeon, anesthesiologist, scrub nurse, and surgical technologist. Usual site of service is an operating room in an acute care hospital or an ambulatory surgical center affiliated with a transplant program when applicable. The service is operative and intraoperative in nature and is reported by the surgeon who performs the back-table preparation and arterial preparation for anastomosis of the previously harvested small intestine.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    44721Preparation of previously harvested small intestine including arterial preparation for anastomosisPrimary code describing back-table preparation and arterial preparation for a previously harvested intestinal graft.
    44227Laparoscopy, surgical, enterolysis, adhesiolysis (separate procedure)May be performed before graft implantation if adhesions are present in the recipient abdomen.
    44120Enterectomy, resection of small intestine; single resection and anastomosisRecipient bowel resection and anastomosis may occur in conjunction with graft implantation.
    35301Preparation of vessels; intraoperative vessel repair (example arterial preparation)Vascular preparation or repair codes may be reported when additional complex arterial reconstruction is required.
    49900Unlisted procedure, abdomen, peritoneum and omentumFor unusual or nonstandard graft preparation steps not described by existing codes.

    Related Modifiers

    10 rows

    ModifierDescriptionWhen to Use
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    2080P0206X
    207L00000X
    2086S0122X
    208600000X
    207YP0228X
    1223E0200X
    364S00000X
    1223D0004X

    Related ICD-10-CM Codes

    24 rows

    ICD-10-CM CodeDescription
    B95.4Other streptococcus as the cause of diseases classified elsewhere
    D50.9Iron deficiency anemia, unspecified
    E86.0Dehydration
    I74.3Embolism and thrombosis of arteries of the lower extremities
    I82.409Acute embolism and thrombosis of unspecified deep veins of unspecified lower extremity
    I85.01Esophageal varices with bleeding
    K25.9Gastric ulcer, unspecified as acute or chronic, without hemorrhage or perforation
    K26.9Duodenal ulcer, unspecified as acute or chronic, without hemorrhage or perforation
    K27.9Peptic ulcer, site unspecified, unspecified as acute or chronic, without hemorrhage or perforation
    K31.89Other diseases of stomach and duodenum

    Showing 1–10 of 24

    Related Payer Policy Updates

    Specialty: Gastroenterology1 / 3

    10 rows

    PolicyPayerEffective Date
    Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disordersbcbsvermont2026-12-01
    Esophagogastroduodenoscopy (EGD) Coverage Policyevicore2026-11-05
    Radiofrequency Therapy for Fecal IncontinenceCigna2026-10-15
    Magnetic Sphincter Augmentation for the Treatment of Gastroesophageal Reflux Disease (GERD)univerahealthcare2026-10-15
    High-Resolution Anoscopy (HRA)Premera Bluecross2026-10-01
    Gastroesophageal and Gastrointestinal (GI) Services and ProceduresColorado Rocky Mountain Health Plans2026-10-01
    Fecal Analysis in the Diagnosis of Intestinal Dysbiosis and Fecal Microbiota Transplant TestingOscar Health2026-10-01
    Serum Testing for Hepatic Fibrosis in the Evaluation and Monitoring of Chronic Liver DiseaseOscar Health2026-10-01
    Pancreatic Enzyme Testing for Acute PancreatitisOscar Health2026-10-01
    Helicobacter pylori TestingOscar Health2026-10-01

    Related Codes

    CPT-44700-SMALL-BOWEL-PELVIC-BARRIER-PLACEMENT

    CPT 44700: Placement of Barrier Between Small Intestine and Pelvis

    CPT-44701-COLON-IRRIGATION-DURING-COLECTOMY-OR-REPAIR

    CPT 44701: Colon Irrigation During Colectomy

    CPT-44705-DONOR-STOOL-SCREENING-AND-PREPARATION-FOR-INSTILLATION

    CPT 44705: Donor Stool Testing and Preparation for Instillation

    CPT-44715-INTESTINAL-GRAFT-PREPARATION-SUPERIOR-MESENTERIC-VESSELS

    CPT 44715: Preparation of Harvested Small Intestine for Anastomosis

    CPT-44720-SMALL-INTESTINE-PREPARATION-FOR-ANASTOMOSIS

    CPT 44720: Preparation of Previously Harvested Small Intestine

    CPT-44799-UNLISTED-INTESTINAL-PROCEDURE

    CPT 44799: Unlisted Intestinal Procedure

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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