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    v1.0.30
    OpenPayerBilling CodesOther Procedures on the Intestines (Except Rectum)CPT cpt-44705-donor-stool-screening-and-preparation-for-instillation
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    CPT 44705: Donor Stool Testing and Preparation for Instillation

    CPT code 44705 describes laboratory testing of donor stool for bacteria, viruses, and syphilis and preparation of the specimen for instillation; this represents a donor stool screening and processing service typically provided as laboratory and specimen preparation work in a hospital outpatient laboratory, specialized stool bank, or clinic setting prior to fecal microbiota transplantation or other instillation procedures.

    For related coverage guidance, see recent payer policy updates: Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disorders, Esophagogastroduodenoscopy (EGD) Coverage Policy, Radiofrequency Therapy for Fecal Incontinence.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient scenario involves an adult with recurrent Clostridioides difficile infection or another microbiome-related condition referred for fecal microbiota transplantation (FMT). The donor stool is obtained from a screened, healthy donor and delivered to the clinical laboratory. The laboratory provider performs comprehensive infectious testing for enteric bacterial pathogens, viral pathogens, and syphilis, documents results, and then prepares the stool specimen into an instillation-ready product (e.g., filtered, aliquoted, suspended) for delivery to the treating clinician. The workflow includes donor screening and consent, laboratory testing (culture, PCR, serology), processing under aseptic conditions, quality control documentation, and labeling for instillation by colonoscopic infusion, nasoenteric tube, or capsule administration. Typical site of service is an outpatient clinical laboratory or hospital-based laboratory associated with a gastroenterology or infectious disease clinic. The typical patient is medically stable but has failed standard antibiotic therapy and is scheduled for FMT by a gastroenterologist; the lab-prepared material is transferred to the procedure suite or outpatient clinic on the day of instillation.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    44705Preparation of donor stool for instillation including testing for bacteria, viruses, and syphilisPrimary code describing donor stool testing and preparation prior to fecal microbiota transplantation
    45355Colonoscopy, flexible; with biopsy, single or multipleMay be used for endoscopic instillation of prepared donor stool during FMT via colonoscopy
    45378Colonoscopy, flexible; therapeutic, e.g., dilation, stent placement (other than polypectomy)May be used when therapeutic colonoscopic maneuvers are performed in conjunction with instillation
    44388Colonoscopy, flexible; with directed submucosal injection(s), any substanceMay be used when instillation requires targeted injection techniques into the colon wall during FMT procedures
    99152Moderate sedation services provided by the same physician performing the diagnostic or therapeutic service, initial 15 minutesUsed when moderate sedation is provided by the physician during instillation procedures in the outpatient or ambulatory surgery setting
    99417Prolonged office or other outpatient evaluation and management service beyond the total time of the primary serviceMay apply to extensive documentation or coordination related to donor testing and preparation if time thresholds are met

    Related Modifiers

    10 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    82Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208000000X
    363LF0000X
    282N00000X
    2279P1006X
    209800000X
    261QM0801X
    207WX0009X
    207VX0201X

    Related Payer Policy Updates

    Specialty: Gastroenterology1 / 3

    10 rows

    PolicyPayerEffective Date
    Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disordersbcbsvermont2026-12-01
    Esophagogastroduodenoscopy (EGD) Coverage Policyevicore2026-11-05
    Radiofrequency Therapy for Fecal IncontinenceCigna2026-10-15
    Magnetic Sphincter Augmentation for the Treatment of Gastroesophageal Reflux Disease (GERD)univerahealthcare2026-10-15
    High-Resolution Anoscopy (HRA)Premera Bluecross2026-10-01
    Gastroesophageal and Gastrointestinal (GI) Services and ProceduresColorado Rocky Mountain Health Plans2026-10-01
    Fecal Analysis in the Diagnosis of Intestinal Dysbiosis and Fecal Microbiota Transplant TestingOscar Health2026-10-01
    Serum Testing for Hepatic Fibrosis in the Evaluation and Monitoring of Chronic Liver DiseaseOscar Health2026-10-01
    Pancreatic Enzyme Testing for Acute PancreatitisOscar Health2026-10-01
    Helicobacter pylori TestingOscar Health2026-10-01

    Related Codes

    CPT-44700-SMALL-BOWEL-PELVIC-BARRIER-PLACEMENT

    CPT 44700: Placement of Barrier Between Small Intestine and Pelvis

    CPT-44701-COLON-IRRIGATION-DURING-COLECTOMY-OR-REPAIR

    CPT 44701: Colon Irrigation During Colectomy

    CPT-44715-INTESTINAL-GRAFT-PREPARATION-SUPERIOR-MESENTERIC-VESSELS

    CPT 44715: Preparation of Harvested Small Intestine for Anastomosis

    CPT-44720-SMALL-INTESTINE-PREPARATION-FOR-ANASTOMOSIS

    CPT 44720: Preparation of Previously Harvested Small Intestine

    CPT-44721-SMALL-INTESTINE-PREPARATION-ARTERY-ANASTOMOSIS

    CPT 44721: Preparation of Previously Harvested Small Intestine

    CPT-44799-UNLISTED-INTESTINAL-PROCEDURE

    CPT 44799: Unlisted Intestinal Procedure

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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