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    v1.0.30
    OpenPayerBilling CodesExcision Procedures on the Intestines (Except Rectum)CPT cpt-44100-small-intestine-capsule-biopsy
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    CPT 44100: Small Intestine Biopsy via Oral Capsule

    Medicare pays $93 on average nationally for this procedure.

    CPT code 44100 describes a diagnostic procedure in which a provider performs biopsy of the small intestine using a capsule introduced through the mouth, a form of capsule endoscopy with tissue sampling; the service is an endoscopic diagnostic biopsy typically performed in an endoscopy suite or outpatient procedure area under direct visualization as part of evaluation for small bowel pathology.

    For related coverage guidance, see recent payer policy updates: Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disorders, Esophagogastroduodenoscopy (EGD) Coverage Policy, Radiofrequency Therapy for Fecal Incontinence.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a 45–70-year-old adult with unexplained chronic iron-deficiency anemia, intermittent obscure gastrointestinal bleeding, or malabsorption symptoms after negative upper endoscopy and colonoscopy. The gastroenterologist recommends biopsy of the small intestine using an ingestible biopsy capsule to obtain mucosal tissue samples for histology, celiac disease evaluation, or to identify sources of mid‑gut bleeding. The procedure workflow: pre-procedure evaluation with medical history, medication reconciliation (anticoagulant management), informed consent, and fasting. The patient swallows the biopsy capsule in an outpatient endoscopy suite or ambulatory surgical center. The capsule transmits location and timing; enzymatic or timed release obtains tissue specimens while traversing the small bowel. After capsule retrieval or natural passage, specimens are submitted to pathology. Post-procedure monitoring is brief; patient education includes signs of capsule retention or obstruction. Typical site of service: outpatient endoscopy suite or ambulatory surgical center. Service type: diagnostic outpatient endoscopic biopsy procedure of the small intestine using an ingestible capsule.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    43760Endoscopic insertion of capsule for visualization of small intestine for remote imaging, with interpretation and reportCapsule endoscopy for visualization is commonly performed before or instead of capsule biopsy; imaging-only capsule may precede a biopsy decision.
    43235Esophagogastroduodenoscopy, diagnostic, with or without collection of specimen(s) by brushing or washing (separate procedure)Upper endoscopy is typically performed prior to small-bowel capsule biopsy to exclude proximal sources of bleeding.
    44205Laparoscopy, surgical; small intestine, diagnosticSurgical diagnostic laparoscopy may be used if capsule causes retention or if direct visualization/biopsy is required when capsule sampling is inadequate.
    44120Enterostomy, including biopsy of small intestineOpen surgical small intestine biopsy codes may be used if capsule biopsy is not feasible and a surgical biopsy is required.
    88305Level III surgical pathology, gross and microscopic examinationPathology processing and interpretation code commonly billed for small intestine biopsy specimens obtained by capsule.

    Related Modifiers

    10 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    63Modifier‑63 is appended to surgical CPT codes (20000–69990) when a procedure is performed on a neonate or infant weighing ≤ 4 kg (about 8.8 lbs). The AMA/AAPC definition specifies this use and notes…- Use modifier -63 only for surgical procedures in the CPT 20000–69990 series performed on a neonate or infant who weighs ≤ 4 kg at the time of the procedure; it indicates increased complexity due to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    81Modifier -81 indicates a physician served as a minimal assistant surgeon for part—not all—of an operative procedure. Use when a physician’s assisting role is limited and does not represent full…- Use CPT modifier -81 when a physician acts as a minimum assistant surgeon who assists during only part (a limited portion) of an operative procedure; append -81 to the primary surgical CPT code to…
    82Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    3336M0003X
    207PH0002X
    133VN1301X
    1744R1103X
    2083P0500X
    246ZB0302X
    282NC0060X
    246ZE0500X

    Related Payer Policy Updates

    Specialty: Gastroenterology1 / 4

    10 rows

    PolicyPayerEffective Date
    Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disordersbcbsvermont2026-12-01
    Esophagogastroduodenoscopy (EGD) Coverage Policyevicore2026-11-05
    Radiofrequency Therapy for Fecal IncontinenceCigna2026-10-15
    Magnetic Sphincter Augmentation for the Treatment of Gastroesophageal Reflux Disease (GERD)univerahealthcare2026-10-15
    High-Resolution Anoscopy (HRA)Premera Bluecross2026-10-01
    Gastroesophageal and Gastrointestinal (GI) Services and ProceduresColorado Rocky Mountain Health Plans2026-10-01
    Fecal Analysis in the Diagnosis of Intestinal Dysbiosis and Fecal Microbiota Transplant TestingOscar Health2026-10-01
    Serum Testing for Hepatic Fibrosis in the Evaluation and Monitoring of Chronic Liver DiseaseOscar Health2026-10-01
    Pancreatic Enzyme Testing for Acute PancreatitisOscar Health2026-10-01
    Helicobacter pylori TestingOscar Health2026-10-01

    Related Codes

    CPT-44110-OPEN-EXCISION-INTESTINAL-LESION-SINGLE-INCISION

    CPT 44110: Excision of Lesion(s) From Small or Large Intestine

    CPT-44111-INTESTINAL-LESION-EXCISION-MULTIPLE-INCISIONS

    CPT 44111: Excision of Intestinal Lesions via Multiple Incisions

    CPT-44120-SMALL-INTESTINE-RESECTION-PRIMARY-ANASTOMOSIS

    CPT 44120: Small Bowel Resection with Primary Anastomosis

    CPT-44121-ADDITIONAL-SMALL-INTESTINE-RESECTION-ANASTOMOSIS

    CPT 44121: Additional Small Intestine Resection and Anastomosis

    CPT-44125-SMALL-INTESTINE-RESECTION-WITH-STOMA-CREATION

    CPT 44125: Small Bowel Resection with Enterostomy

    CPT-44126-SMALL-BOWEL-RESECTION-CONGENITAL-ATRESIA-END-TO-END-ANASTOMOSIS

    CPT 44126: Small Bowel Resection for Intestinal Atresia with Anastomosis

    CPT-44127-SMALL-BOWEL-RESECTION-ANASTOMOSIS-INTESTINAL-ATRESIA

    CPT 44127: Resection and Anastomosis for Congenital Small-Bowel Atresia

    CPT-44128-SMALL-BOWEL-RESECTION-ANASTOMOSIS-CONGENITAL-ATRESIA

    CPT 44128: Resection of Small Intestine for Congenital Atresia

    CPT-44130-INTESTINAL-ANASTOMOSIS-BOWEL-RESECTION-ANASTOMOSIS

    CPT 44130: Intestinal Anastomosis, With or Without Stoma

    CPT-44132-DONOR-SMALL-BOWEL-RESECTION-PRESERVATION-FOR-TRANSPLANT

    CPT 44132: Open Small Intestine Resection for Transplant Preservation

    Showing 1–10 of 29

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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