CPT code 43280 represents laparoscopic esophagogastric fundoplasty, a minimally invasive antireflux surgical procedure that reinforces the lower esophageal sphincter by wrapping the gastric fundus around the distal esophagus. The procedure matters nationally because GERD is a common condition and fundoplasty is a definitive surgical option for patients who fail or cannot tolerate medical therapy, impacting hospital and ambulatory surgical volumes and surgical specialty practice patterns. Key payers in the overview include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise clinical and billing context for the procedure, typical sites of service, common modifiers used in billing, and the payer mix considered in benchmarking. The publication outlines what to expect in terms of coding identification, clinical indications, and the types of comparisons and policy updates typically relevant to this code. Data not available in the input is noted where applicable; the focus remains on delivering a clear, national-level summary of the code’s clinical role and payer coverage landscape rather than state-specific policy details.