CPT code 33287 defines the removal and replacement of a phrenic nerve stimulator pulse generator, including vessel catheterization, imaging guidance, and device interrogation and programming when performed. This procedure is clinically important for patients with diaphragmatic pacing systems whose pulse generator has failed, reached end of service, or requires replacement for clinical management. Nationally, the code captures a focused set of device-replacement services tied to implantable neurostimulation therapy.

Key payers in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise review of what the code represents, typical sites of service, and the clinical context for generator replacement. The publication provides benchmarks for utilization and allowed amounts where available, common billing modifiers and coding considerations, and comparisons across major payers. It also summarizes procedural components bundled into the code and highlights areas where payer policy language commonly appears, such as device longevity, medical necessity criteria, and facility setting requirements.

The content is intended for billing professionals, clinicians involved in device management, and policy analysts seeking a national view of CPT code 33287's clinical definition, coding scope, and payer-relevant considerations.