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    OpenPayerBilling CodesExcision Procedures on the Femur (Thigh Region) and Knee JointCPT cpt-27325-hamstring-neurectomy-nerve-excision
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    CPT 27325: Neurectomy of Nerve Along Hamstring

    Medicare pays $552 on average nationally for this procedure.

    CPT code 27325 describes a surgical neurectomy (full or partial excision of a nerve) performed along the hamstring muscle to relieve painful muscle spasms; this is a reconstructive/operative soft-tissue procedure typically performed in an operating room or ambulatory surgical center under regional or general anesthesia and involves direct nerve excision in the posterior thigh for focal spasm relief.

    For related coverage guidance, see recent payer policy updates: Removal of Implantable, Outpatient Surgical Procedures - Site of Service, Surgical Procedures.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 45-year-old patient presents with chronic, refractory posterior thigh pain and recurrent hamstring muscle spasms after prior traumatic injury and persistent nerve entrapment. Conservative measures including physical therapy, oral analgesics, nerve blocks, and targeted botulinum toxin injections have failed to provide durable relief. The orthopedic or peripheral nerve surgeon evaluates the patient, documents localized tenderness along the proximal hamstring and corresponding sensory or motor findings consistent with a symptomatic terminal branch of the posterior femoral cutaneous nerve or a branch of the sciatic nerve. Preoperative workup includes focused history and physical, diagnostic imaging (ultrasound or MRI) to exclude mass lesions, and diagnostic peripheral nerve block confirming temporary pain relief.

    In the operating room or ambulatory surgical center, the surgeon performs a neurectomy (partial or complete excision of the involved nerve) along the hamstring muscle to interrupt nociceptive signaling and relieve painful muscle spasms. The procedure typically uses regional or general anesthesia, sterile technique, and identification of the targeted nerve through anatomical landmarks and direct visualization; intraoperative nerve stimulation may be used to confirm target. Postoperative care includes short observation, analgesia, wound care, activity restrictions, and follow-up to assess pain control and potential sensory deficits. Billing aligns with a surgical procedure code for neurectomy of a nerve in the hamstring region, reported for facility and professional components as appropriate.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    64450Injection, anesthetic agent; other peripheral nerve or branchDiagnostic or therapeutic peripheral nerve block used preoperatively to confirm the targeted nerve as the pain generator.
    20610Arthrocentesis, aspiration and/or injection, major joint or bursa (e.g., hip)May be used when excluding intra-articular causes or providing concurrent injections for differential diagnosis of posterior thigh pain.
    29880Endoscopy, knee, surgical; arthrotomy with debridement (example related arthroscopic codes)Listed as a related surgical code when arthroscopic evaluation or concurrent knee procedures are performed in the same operative session; used if multiple procedures reported.
    95970Somatosensory evoked potential study; limitedIntraoperative neurophysiologic monitoring code when monitoring is used during neurectomy to protect neural structures.
    64721Neuroplasty and/or transposition; peripheral nerve (e.g., for entrapment)Alternative or adjacent peripheral nerve surgical procedures addressing entrapment that may be considered in the same clinical pathway.

    Related Modifiers

    12 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    81Modifier -81 indicates a physician served as a minimal assistant surgeon for part—not all—of an operative procedure. Use when a physician’s assisting role is limited and does not represent full…- Use CPT modifier -81 when a physician acts as a minimum assistant surgeon who assists during only part (a limited portion) of an operative procedure; append -81 to the primary surgical CPT code to…
    82Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…

    Showing 1–10 of 12

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207N00000X
    2084P0800X
    208000000X
    208D00000X
    207L00000X
    335E00000X
    363LP0222X
    163WN1003X

    Related ICD-10-CM Codes

    23 rows

    ICD-10-CM CodeDescription
    G56.11Other lesions of median nerve, right upper limb
    G56.12Other lesions of median nerve, left upper limb
    G57.01Lesion of sciatic nerve, right lower limb
    G57.02Lesion of sciatic nerve, left lower limb
    G57.11Meralgia paresthetica, right lower limb
    G57.12Meralgia paresthetica, left lower limb
    G57.81Other specified mononeuropathies of right lower limb
    G57.82Other specified mononeuropathies of left lower limb
    G89.29Other chronic pain
    G89.4Chronic pain syndrome

    Showing 1–10 of 23

    Related Payer Policy Updates

    Specialty: General Surgery1 / 3

    10 rows

    PolicyPayerEffective Date
    Removal of ImplantableBlue Cross Blue Shield - Rhode Island2026-10-01
    Outpatient Surgical Procedures - Site of ServiceUnitedHealthcare2026-09-01
    Surgical ProceduresUnitedHealthcare2026-09-01
    Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Site of Service for Ambulatory Surgical Procedures (ASC Select)Premera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Medical Necessity Guidelines Inpatient Surgical CareMass General Brigham Health Plan2026-08-01
    Outpatient Surgical Procedures - Site of Servicesierra health and life2026-08-01

    Related Codes

    CPT-27323-EXCISIONAL-BIOPSY-THIGH-KNEE-SUPERFICIAL-SOFT-TISSUE

    CPT 27323: Excisional Biopsy of Superficial Soft Tissue, Thigh or Knee

    CPT-27324-DEEP-SOFT-TISSUE-BIOPSY-THIGH-KNEE

    CPT 27324: Deep Tissue/Muscle Biopsy of Thigh or Knee

    CPT-27326-POPLITEAL-GASTROCNEMIUS-NERVE-EXCISION-FOR-SPASM

    CPT 27326: Neurectomy of Popliteal/Gastrocnemius Nerve for Spasm

    CPT-27327-SUBCUTANEOUS-TUMOR-EXCISION-THIGH-KNEE

    CPT 27327: Excision of Subcutaneous Tumor of Thigh or Knee (<3 cm)

    CPT-27328-INTRAMUSCULAR-THIGH-KNEE-TUMOR-EXCISION-SMALL

    CPT 27328: Excision of Intramuscular Tumor of Thigh or Knee (<5 cm)

    CPT-27329-EXTENSIVE-EXCISION-SOFT-TISSUE-TUMOR-THIGH-KNEE-LESS-5CM

    CPT 27329: Extensive Excision of Soft-Tissue Tumor, Thigh/Knee (<5 cm)

    CPT-27330-KNEE-SYNOVIAL-BIOPSY-SURGICAL-DIAGNOSTIC

    CPT 27330: Open Biopsy of Synovium of Knee

    CPT-27331-KNEE-ARTHROTOMY-BIOPSY-LOOSE-BODY-REMOVAL

    CPT 27331: Knee Arthrotomy with Synovial Biopsy and Loose Body Removal

    CPT-27332-KNEE-ARTHROTOMY-MENISCAL-EXCISION

    CPT 27332: Arthrotomy with Excision of Medial or Lateral Meniscus

    CPT-27333-KNEE-PARTIAL-MENISCECTOMY-MEDIAL-AND-LATERAL

    CPT 27333: Meniscectomy, Medial and Lateral Knee

    Showing 1–10 of 25

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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