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    v1.0.30
    OpenPayerBilling CodesExcision Procedures on the Back and FlankCPT cpt-21920-superficial-soft-tissue-biopsy-back-flank
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    CPT 21920: Superficial Soft Tissue Biopsy of Back or Flank

    Medicare pays $273 on average nationally for this procedure.

    CPT code 21920 describes a superficial soft tissue biopsy of the back or flank performed to obtain a tissue sample (such as a small subcutaneous lump) for pathological analysis; service type: diagnostic soft tissue biopsy; typical site of service: outpatient clinic, physician office, or ambulatory surgery setting for specimen collection and submission to pathology.

    For related coverage guidance, see recent payer policy updates: Destruction of Pre-Malignant Skin Lesions, Onychomycosis diagnostic testing and coverage, Treatment of Capillary Malformations (Port Wine Stains).

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 54-year-old patient presents to an outpatient surgical clinic with a 1.2 cm, firm, subcutaneous nodule in the left paraspinal area of the mid-back noticed progressively enlarging over two months. The lesion is mobile relative to deeper structures, non-tender, and clinically suspicious for a lipoma versus epidermal inclusion cyst or cutaneous malignancy. The provider discusses diagnostic options and performs a superficial soft tissue biopsy under local anesthesia to obtain a representative tissue sample. The specimen is placed in appropriate fixative and sent to pathology for histologic evaluation and, if indicated, immunohistochemistry to rule out spindle cell neoplasm or metastatic disease.

    The clinical workflow includes pre-procedure verification and consent, marking the biopsy site, sterile prep, local infiltration of anesthetic, elliptical or punch excision/incisional biopsy of the superficial lesion, hemostasis, wound closure or dressing, specimen labeling and requisition completion, and communication of anticipated pathology turnaround. Typical documentation captures lesion location (back/flank), size, depth, anesthetic used, technique (punch, excision, incisional), number of specimens, and specimen disposition.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    11102Tangential biopsy of skin (e.g., shave, scooping of lesion) including simple closure, single lesionAlternative technique for sampling superficial skin lesions when a shave or tangential approach is appropriate instead of a deeper soft tissue biopsy.
    11104Punch biopsy of skin, single lesionCommonly used technique for superficial cutaneous and subcutaneous lesions when a core sample is sufficient for diagnosis.
    20610Arthrocentesis, aspiration and/or injection; major joint or bursa (e.g., shoulder, hip)Not directly the same anatomic area but may be performed if fluid aspiration of a superficial soft tissue mass is indicated before or instead of biopsy.
    26010Incision and drainage, tendon sheath, or ganglion cyst; simplePerformed when the clinical impression is a ganglion or cyst and limited drainage or simple excision is performed instead of a biopsy.
    99000Handling and/or conveyance of specimen for transfer from the office to a laboratoryAncillary billing code relevant for specimen handling logistics associated with sending the biopsy to pathology.
    88305Level IV surgical pathology, gross and microscopic examinationRepresentative pathology CPT code used by laboratories to report histologic evaluation of a soft tissue biopsy specimen; often billed by the laboratory, not the biopsy-performing provider.

    Related Modifiers

    12 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Showing 1–10 of 12

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    2080P0207X
    207Q00000X
    208600000X
    2086S0122X
    207L00000X
    2080C0008X
    207QB0002X
    207RA0002X

    Related ICD-10-CM Codes

    23 rows

    ICD-10-CM CodeDescription
    C44.509Unspecified malignant neoplasm of skin of other part of trunk
    D17.4Benign lipomatous neoplasm of intrathoracic organs
    D22.5Melanocytic nevi of trunk
    D23.9Other benign neoplasm of skin, unspecified
    I83.10Varicose veins of unspecified lower extremity with inflammation
    I83.819Varicose veins of unspecified lower extremity with pain
    L03.116Cellulitis of left lower limb
    L87.8Other transepidermal elimination disorders
    L89.309Pressure ulcer of unspecified buttock, unspecified stage
    L91.0Hypertrophic scar

    Showing 1–10 of 23

    Related Payer Policy Updates

    Specialty: Dermatology1 / 3

    10 rows

    PolicyPayerEffective Date
    Destruction of Pre-Malignant Skin LesionsAnthem2026-10-01
    Onychomycosis diagnostic testing and coverageOscar Health2026-10-01
    Treatment of Capillary Malformations (Port Wine Stains)universityofutahhealthplans2026-09-28
    AnzupgoCigna2026-09-15
    Zevaskyn Coverage for Recessive Dystrophic Epidermolysis BullosaCigna2026-09-01
    Topical Acne-Non-Retinoid ProductsCigna2026-08-15
    Dermatology - Vtama Drug Quantity Management Policy - Per DaysCigna2026-08-15
    Medical Necessity Guidelines: Acne and Rosacea Medicationsharvard pilgrim health care2026-08-11
    Dermatology - Anzupgo Prior Authorization PolicyCigna2026-08-05
    Light Therapy for Dermatologic Conditionsbcbsvermont2026-08-01

    Related Codes

    CPT-21925-DEEP-SOFT-TISSUE-BIOPSY-BACK-FLANK

    CPT 21925: Deep Soft Tissue Biopsy of Back or Flank

    CPT-21930-SOFT-TISSUE-MASS-EXCISION-BACK-FLANK-LESS-THAN-3CM

    CPT 21930: Excision of Subcutaneous Soft-Tissue Lesion, Back/Flank (<3 cm)

    CPT-21931-SOFT-TISSUE-EXCISION-BACK-FLANK-3CM-OR-GREATER

    CPT 21931: Excision of Soft Tissue Mass of Back/Flank ≥3 cm

    CPT-21932-SUBFASCIAL-SOFT-TISSUE-TUMOR-EXCISION-BACK-FLANK

    CPT 21932: Subfascial Soft Tissue Tumor Excision, Back/Flank (<5 cm)

    CPT-21933-SUBFASCIAL-SOFT-TISSUE-TUMOR-EXCISION-BACK-FLANK-5CM-PLUS

    CPT 21933: Subfascial Soft Tissue Tumor Excision, Back or Flank (≥5 cm)

    CPT-21935-EXTENSIVE-EXCISION-SOFT-TISSUE-TUMOR-BACK-FLANK-LESS-5CM

    CPT 21935: Extensive Excision of Malignant Soft Tissue Tumor, Back/Flank <5cm

    CPT-21936-EXTENSIVE-EXCISION-SOFT-TISSUE-SARCOMA-BACK-FLANK-5CM

    CPT 21936: Extensive Excision of Large Soft Tissue Malignant Tumor

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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