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    v1.0.28
    OpenPayerBilling CodesAutografts/Tissue Cultured AutograftCPT cpt-15156-tissue-cultured-epidermal-autograft-additional-cm2
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    CPT 15156: Tissue Cultured Epidermal Autograft, Additional 1 cm2

    Medicare pays $170 on average nationally for this procedure.

    CPT code 15156 describes placement of a tissue cultured epidermal autograft for reconstruction of facial, scalp, eyelid, oral, neck, ear, orbital, genital, hand, foot, and/or multiple digit defects, billed for each additional 1 cm2 of grafted skin after the initial 25 cm2; service type: surgical skin grafting using cultured epidermal autograft; typical site of service: operating room, ambulatory surgical center, or hospital inpatient setting for complex reconstructive procedures.

    For related coverage guidance, see recent payer policy updates: Onychomycosis diagnostic testing and coverage, Topical Acne-Non-Retinoid Products, Dermatology - Vtama Drug Quantity Management Policy - Per Days.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 42-year-old male with extensive full-thickness facial and neck burns following a house fire undergoes staged reconstruction. After initial wound excision and stabilization, the burn surgery team prepares to apply a tissue-cultured epidermal autograft to replace lost epidermis over areas of the face, scalp, eyelids, mouth, and neck. The procedure using 15156 is billed for each additional 1 cm2 of graft applied after the initial 25 cm2 covered by the primary graft code. Typical workflow includes preoperative assessment by a burn/plastic surgeon, harvesting of a small skin biopsy sent to a laboratory for epidermal cell culture, operative placement of the cultured epidermal sheets under sterile conditions in the operating room or burn unit, monitoring for graft take, and staged outpatient follow-up for wound care and functional/aesthetic rehabilitation.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    15271Application of skin substitute graft to face, scalp, eyelids, mouth, neck, ears, orbits, genitalia, hands, feet, and/or multiple digits; first 25 cm2 or lessOften billed as the primary code covering the initial 25 cm2 of cultured epidermal autograft; 15156 is used for each additional cm2 after that initial area.
    15272Application of skin substitute graft to face, scalp, eyelids, mouth, neck, ears, orbits, genitalia, hands, feet, and/or multiple digits; each additional 25 cm2, or part thereofUsed when larger surface areas require staged billing increments beyond the first 25 cm2 and additional 25 cm2 blocks are billed.
    15275Application of dermal substitute graft to trunk, arms, legs, total body surface area up to 1000 cm2May be used in conjunction for larger body sites when combined reconstructive strategies are required.
    12002Simple repair of superficial wounds of face, ears, eyelids, nose, mouth; 2.5 cm or lessCommonly performed for adjunctive wound closure adjacent to grafted areas.
    15002Tangential excision (e.g., laser dermabrasion) of burn scar or wound preparation — Data not available in the input.Data not available in the input.

    Related Modifiers

    13 rows

    ModifierDescriptionWhen to Use
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    63Modifier‑63 is appended to surgical CPT codes (20000–69990) when a procedure is performed on a neonate or infant weighing ≤ 4 kg (about 8.8 lbs). The AMA/AAPC definition specifies this use and notes…- Use modifier -63 only for surgical procedures in the CPT 20000–69990 series performed on a neonate or infant who weighs ≤ 4 kg at the time of the procedure; it indicates increased complexity due to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…

    Showing 1–10 of 13

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    208D00000XGeneral Practice PhysicianA physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
    207P00000XEmergency Medicine PhysicianAn emergency physician focuses on the immediate decision making and action necessary to prevent death or any further disability both in the pre-hospit…
    2081H0002XHospice and Palliative Medicine (Physical Medicine & Rehabilitation) PhysicianA physical medicine and rehabilitation physician with special knowledge and skills to prevent and relieve the suffering experienced by patients with l…
    207VX0201XGynecologic Oncology PhysicianAn obstetrician/gynecologist who provides consultation and comprehensive management of patients with gynecologic cancer, including those diagnostic an…
    101YP2500XProfessional CounselorBehavioral Health & Social Service Providers · Counselor
    207XS0114XAdult Reconstructive Orthopaedic Surgery PhysicianRecognized by several state medical boards as a fellowship subspecialty program of orthopaedic surgery, adult reconstructive orthopaedic surgeons deal…
    163WP1700XPerinatal Registered NurseNursing Service Providers · Registered Nurse

    Related Payer Policy Updates

    Specialty: Dermatology1 / 3

    5 rows

    PolicyPayerEffective Date
    Onychomycosis diagnostic testing and coverageOscar Health2026-10-01
    Topical Acne-Non-Retinoid ProductsCigna2026-08-15
    Dermatology - Vtama Drug Quantity Management Policy - Per DaysCigna2026-08-15
    Medical Necessity Guidelines: Acne and Rosacea Medicationsharvard pilgrim health care2026-08-11
    Winlevi (clascoterone 1% cream) — Topical AcneCigna2026-08-01

    Related Codes

    CPT-15040-SKIN-HARVEST-TISSUE-CULTURED-AUTOGRAFT

    CPT 15040: Harvest of Skin for Tissue Cultured Skin Autograft (≤100 cm2)

    CPT-15050-PINCH-GRAFT-SKIN-GRAFTING-SMALL-DEFECT

    CPT 15050: Pinch Graft, Skin, Up to 2 cm

    CPT-15100-SPLIT-THICKNESS-AUTOGRAFT-TRUNK-ARMS-LEGS

    CPT 15100: Split-Thickness Autograft from Trunk/Arms/Legs

    CPT-15101-SPLIT-THICKNESS-AUTOGRAFT-ADDITIONAL-100CM2

    CPT 15101: Split-Thickness Autograft, Additional 100 cm²

    CPT-15110-EPIDERMAL-AUTOGRAFT-TRUNK-ARMS-LEGS

    CPT 15110: Epidermal Autograft, Trunk/Arms/Legs

    CPT-15111-EPIDERMAL-AUTOGRAFT-TRUNK-ARMS-LEGS-ADDITIONAL

    CPT 15111: Epidermal Autograft, Trunk/Arms/Legs (per 100 cm2)

    CPT-15115-EPIDERMAL-AUTOGRAFT-FACE-AND-SENSITIVE-AREAS

    CPT 15115: Epidermal Autograft for Face/Scalp/Hands/Feet

    CPT-15116-EPIDERMAL-AUTOGRAFT-FACE-SCALP-HANDS-FEET

    CPT 15116: Epidermal Autograft for Face, Hands, Feet, Multiple Digits

    CPT-15120-SPLIT-THICKNESS-AUTOGRAFT-FACE-HANDS-FEET

    CPT 15120: Split‑Thickness Autograft, Face/Scalp (first 100 sq cm)

    CPT-15121-SPLIT-THICKNESS-AUTOGRAFT-ADDITIONAL-100-SQ-CM

    CPT 15121: Split-Thickness Autograft for Face, Scalp, Eyelids, Mouth, Neck, Ears

    Showing 1–10 of 27

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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