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    v1.0.28
    OpenPayerBilling CodesAutografts/Tissue Cultured AutograftCPT cpt-15157-tissue-cultured-epidermal-autograft-additional-area
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    CPT 15157: Tissue‑Cultured Epidermal Autograft, Additional 100 cm2

    Medicare pays $191 on average nationally for this procedure.

    CPT code 15157 describes placement of a tissue-cultured epidermal autograft for reconstruction of small or complex areas such as the face, scalp, eyelids, mouth, neck, ears, orbits, genitalia, hands, feet, and multiple digits; this code is reported for each additional 100 cm2 (or each additional 1% body area in infants/children) beyond the first 100 cm2. The service type is skin grafting using tissue-cultured epidermal autograft, typically performed in operating room or procedural surgical settings for reconstruction after burns, extensive wounds, or other surgical defects involving the specified anatomic sites.

    For related coverage guidance, see recent payer policy updates: Onychomycosis diagnostic testing and coverage, Topical Acne-Non-Retinoid Products, Dermatology - Vtama Drug Quantity Management Policy - Per Days.

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    Clinical & Coding Specifications

    Clinical Context

    A pediatric patient with extensive full-thickness facial and neck burns undergoes placement of a tissue-cultured epidermal autograft to restore epidermal coverage of the face and adjacent areas. The clinical workflow begins with inpatient burn stabilization, debridement and wound bed preparation under general anesthesia in the operating room. A small split-thickness skin sample is harvested and sent to a lab for epidermal cell culture. After sufficient epidermal sheet growth, the patient returns to the OR for placement of the cultured epidermal autograft. Intraoperative documentation includes graft surface area measured in square centimeters (or percent body surface area for infants/children), graft site(s) limited to face, scalp, eyelids, mouth, neck, ears, orbits, genitalia, hands, feet, and/or multiple digits, and any concurrent procedures. Postoperative care includes graft surveillance, dressing management, pain control, and outpatient follow-up for graft take and functional/cosmetic outcomes. Billing reflects the initial 100 cm2 (or 1% BSA pediatric increment) and uses additional units of 15157 for each extra 100 cm2 (or each additional 1% in infants/children) beyond the first unit.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    15002Split-thickness autograft, first 100 sq cm or less, or 1% BSA of children; trunk, arms, legsPerformed for donor-site harvesting prior to epidermal culture or for alternative autografting when cultured grafts are not used.
    15271Application of skin substitute graft to trunk, arms, legs; first 100 sq cm or lessSkin substitute application may be performed in conjunction with or as an alternative to cultured epidermal autografts for large wounds.
    15780Excision, extensive, full-thickness burn scar; face, head, neck, hands, feet, genitaliaSecondary reconstructive procedures for scar revision after initial grafting and healing.
    11042Debridement, subcutaneous tissue (includes surgical preparation of wound bed)Debridement and wound bed preparation frequently precede placement of a cultured epidermal autograft.
    11981Replacement of tissue expander with permanent implant, trunkReconstructive steps such as tissue expansion and implant exchange may occur in staged reconstructive workflows following grafting.
    15734Muscle, myocutaneous, or fasciocutaneous flap with microvascular anastomosisComplex reconstruction adjuncts when skin grafting is insufficient for deep tissue defects.

    Related Modifiers

    13 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    63Modifier‑63 is appended to surgical CPT codes (20000–69990) when a procedure is performed on a neonate or infant weighing ≤ 4 kg (about 8.8 lbs). The AMA/AAPC definition specifies this use and notes…- Use modifier -63 only for surgical procedures in the CPT 20000–69990 series performed on a neonate or infant who weighs ≤ 4 kg at the time of the procedure; it indicates increased complexity due to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    73Modifier 73 indicates a facility-level outpatient hospital or ASC procedure that was discontinued after the patient was prepared and taken to the procedure/operating room but before any anesthesia…- When to use: Apply CPT modifier 73 on the FACILITY (outpatient hospital or ASC) claim when the patient has been fully prepared and physically taken into the procedure/operating room but the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…

    Showing 1–10 of 13

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    208600000XSurgery PhysicianA general surgeon has expertise related to the diagnosis - preoperative, operative and postoperative management - and management of complications of s…
    2084P0800XPsychiatry PhysicianA Psychiatrist specializes in the prevention, diagnosis, and treatment of mental disorders, emotional disorders, psychotic disorders, mood disorders, …
    2081H0002XHospice and Palliative Medicine (Physical Medicine & Rehabilitation) PhysicianA physical medicine and rehabilitation physician with special knowledge and skills to prevent and relieve the suffering experienced by patients with l…
    364SX0204XPediatric Oncology Clinical Nurse SpecialistPhysician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist
    172A00000XDriverA person employed to operate a motor vehicle as a carrier of persons or property.
    253Z00000XIn Home Supportive Care AgencyAn In Home Supportive Care Agency provides services in the patient's home with the goal of enabling the patient to remain at home. The services provi…
    163WH0200XHome Health Registered NurseNursing Service Providers · Registered Nurse
    2085H0002XHospice and Palliative Medicine (Radiology) PhysicianA radiologist with special knowledge and skills to prevent and relieve the suffering experienced by patients with life-limiting illnesses. This specia…

    Related Payer Policy Updates

    Specialty: Dermatology1 / 3

    5 rows

    PolicyPayerEffective Date
    Onychomycosis diagnostic testing and coverageOscar Health2026-10-01
    Topical Acne-Non-Retinoid ProductsCigna2026-08-15
    Dermatology - Vtama Drug Quantity Management Policy - Per DaysCigna2026-08-15
    Medical Necessity Guidelines: Acne and Rosacea Medicationsharvard pilgrim health care2026-08-11
    Winlevi (clascoterone 1% cream) — Topical AcneCigna2026-08-01

    Related Codes

    CPT-15040-SKIN-HARVEST-TISSUE-CULTURED-AUTOGRAFT

    CPT 15040: Harvest of Skin for Tissue Cultured Skin Autograft (≤100 cm2)

    CPT-15050-PINCH-GRAFT-SKIN-GRAFTING-SMALL-DEFECT

    CPT 15050: Pinch Graft, Skin, Up to 2 cm

    CPT-15100-SPLIT-THICKNESS-AUTOGRAFT-TRUNK-ARMS-LEGS

    CPT 15100: Split-Thickness Autograft from Trunk/Arms/Legs

    CPT-15101-SPLIT-THICKNESS-AUTOGRAFT-ADDITIONAL-100CM2

    CPT 15101: Split-Thickness Autograft, Additional 100 cm²

    CPT-15110-EPIDERMAL-AUTOGRAFT-TRUNK-ARMS-LEGS

    CPT 15110: Epidermal Autograft, Trunk/Arms/Legs

    CPT-15111-EPIDERMAL-AUTOGRAFT-TRUNK-ARMS-LEGS-ADDITIONAL

    CPT 15111: Epidermal Autograft, Trunk/Arms/Legs (per 100 cm2)

    CPT-15115-EPIDERMAL-AUTOGRAFT-FACE-AND-SENSITIVE-AREAS

    CPT 15115: Epidermal Autograft for Face/Scalp/Hands/Feet

    CPT-15116-EPIDERMAL-AUTOGRAFT-FACE-SCALP-HANDS-FEET

    CPT 15116: Epidermal Autograft for Face, Hands, Feet, Multiple Digits

    CPT-15120-SPLIT-THICKNESS-AUTOGRAFT-FACE-HANDS-FEET

    CPT 15120: Split‑Thickness Autograft, Face/Scalp (first 100 sq cm)

    CPT-15121-SPLIT-THICKNESS-AUTOGRAFT-ADDITIONAL-100-SQ-CM

    CPT 15121: Split-Thickness Autograft for Face, Scalp, Eyelids, Mouth, Neck, Ears

    Showing 1–10 of 27

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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