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    v1.0.30
    OpenPayerBilling CodesFine Needle Aspiration Biopsy ProceduresCPT cpt-10021-fine-needle-aspiration-first-lesion-biopsy
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    CPT 10021: Fine Needle Aspiration (First Lesion)

    Medicare pays $104 on average nationally for this procedure.

    CPT code 10021 describes a fine needle aspiration (FNA) diagnostic procedure in which a provider collects a small number of cells, tissue fragments, or fluid from a cyst or palpable mass for cytologic evaluation; this code is used for the first lesion sampled and represents an outpatient minor surgical/diagnostic biopsy service typically performed in an office, clinic, or outpatient procedure setting using a specialized needle and syringe.

    For related coverage guidance, see recent payer policy updates: Destruction of Pre-Malignant Skin Lesions, Onychomycosis diagnostic testing and coverage, Treatment of Capillary Malformations (Port Wine Stains).

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    Clinical & Coding Specifications

    Clinical Context

    A 52-year-old patient presents to an outpatient dermatology clinic with a palpable 1.5 cm subcutaneous nodule on the right lateral neck that has persisted for several weeks. The clinician performs a 10021 fine needle aspiration (FNA) of the first palpable lesion to obtain cellular material for cytologic evaluation. The workflow includes focused history and consent, physical exam and site preparation, lesion localization by palpation (or ultrasound if needed), local anesthesia if indicated, insertion of a fine needle with aspiration to collect material, placement of aspirate onto slides and into fixative or transport media, and immediate labeling and documentation of the specimen and procedure. Specimen handling may include on-site assessment by cytology (ROSE) or sending to the laboratory for processing. The encounter is typically conducted in an ambulatory clinic, dermatology office, surgical office, or outpatient procedure suite and is billed as a diagnostic procedure for the first lesion biopsied using 10021.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    10022Fine needle aspiration; with imaging guidanceUsed when the FNA is performed with ultrasound or other imaging guidance rather than palpation.

    | 10120 | Incision and drainage of a lesion (eg, cyst) | Performed when an aspirated lesion requires drainage or excision following diagnostic FNA.

    | 11100 | Biopsy of single lesion, skin; shave, single lesion | Alternative or subsequent biopsy technique when tissue architecture is required beyond cytology.

    | 19000 | Puncture aspiration of cyst of breast | Specific site-based aspiration procedure for breast cysts; related when site dictates code selection.

    | 88172 | Cytopathology, immediate interpretation (ROSE) | Reported when rapid on-site evaluation of FNA specimens is performed by a cytopathologist or qualified professional.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    25CPT modifier 25 indicates that on the same day as another procedure or service, the same physician or other qualified health care professional provided a significant, separately identifiable…- When to apply: Use modifier 25 only on an E/M code to indicate the same provider delivered a significant, separately identifiable E/M service on the same day as another procedure or service — i.e.,…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207N00000X
    207L00000X
    208D00000X
    363A00000X
    207K00000X
    1223P0700X
    207LP4000X
    363LP0200X

    Related Payer Policy Updates

    Specialty: Dermatology1 / 3

    10 rows

    PolicyPayerEffective Date
    Destruction of Pre-Malignant Skin LesionsAnthem2026-10-01
    Onychomycosis diagnostic testing and coverageOscar Health2026-10-01
    Treatment of Capillary Malformations (Port Wine Stains)universityofutahhealthplans2026-09-28
    AnzupgoCigna2026-09-15
    Zevaskyn Coverage for Recessive Dystrophic Epidermolysis BullosaCigna2026-09-01
    Topical Acne-Non-Retinoid ProductsCigna2026-08-15
    Dermatology - Vtama Drug Quantity Management Policy - Per DaysCigna2026-08-15
    Medical Necessity Guidelines: Acne and Rosacea Medicationsharvard pilgrim health care2026-08-11
    Dermatology - Anzupgo Prior Authorization PolicyCigna2026-08-05
    Light Therapy for Dermatologic Conditionsbcbsvermont2026-08-01

    Related Codes

    CPT-10004-FINE-NEEDLE-ASPIRATION-ADDITIONAL-LESION

    CPT 10004: Fine Needle Aspiration, Additional Lesion

    CPT-10005-ULTRASOUND-GUIDED-FINE-NEEDLE-ASPIRATION-FIRST-LESION

    CPT 10005: Ultrasound-Guided Fine Needle Aspiration, First Lesion

    CPT-10006-ULTRASOUND-GUIDED-FNA-ADDITIONAL-LESION

    CPT 10006: Fine Needle Aspiration, Additional Lesion, Ultrasound-Guided

    CPT-10007-FINE-NEEDLE-ASPIRATION-FLUOROSCOPIC-GUIDANCE

    CPT 10007: Fluoroscopic Fine Needle Aspiration, First Lesion

    CPT-10008-FINE-NEEDLE-ASPIRATION-ADDITIONAL-LESION-FLUOROSCOPIC

    CPT 10008: Fine Needle Aspiration, Additional Lesion

    CPT-10009-CT-GUIDED-FINE-NEEDLE-ASPIRATION-FIRST-LESION

    CPT 10009: CT-Guided Fine Needle Aspiration, First Lesion

    CPT-10010-FINE-NEEDLE-ASPIRATION-ADDITIONAL-LESION-CT-GUIDANCE

    CPT 10010: Fine Needle Aspiration, Additional Lesion

    CPT-10011-MR-GUIDED-FNA-BIOPSY-FIRST-LESION

    CPT 10011: MR-Guided Fine Needle Aspiration, First Lesion

    CPT-10012-MR-GUIDED-FINE-NEEDLE-ASPIRATION-ADDITIONAL-LESION

    CPT 10012: Fine Needle Aspiration, Additional Lesion, MR Guidance

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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