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    v1.0.30
    OpenPayerBilling CodesAutologous Muscle Cell Therapy ProceduresCPT cpt-1000t-urethral-sphincter-muscle-progenitor-cell-injection
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    CPT 1000T: Urethral Sphincter Muscle Progenitor Cell Injection

    CPT code 1000T describes injection of the patient’s own muscle progenitor cells into the urethral sphincter to improve sphincter muscle function; the service is a regenerative cell therapy procedure typically performed as an outpatient operative or ambulatory surgery service and may include intraoperative cystoscopy and ultrasound imaging when performed.

    For related coverage guidance, see recent payer policy updates: Orthopedic Joint Procedures of the Knee for Managed Medicaid (MMC), Health and Recovery Plan (HARP), Child Health Plus (CHP), and Essential Plan (EP) Members, Autologous Chondrocyte Transplantation or Implantation Corporate Medical Policy, Autologous Platelet-Derived Growth Factors (Platelet-Rich Plasma [PRP]).

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    Clinical & Coding Specifications

    Clinical Context

    A 58-year-old female with a history of stress urinary incontinence refractory to conservative therapy (pelvic floor physical therapy, pessary) presents for autologous muscle progenitor cell injection into the external urethral sphincter to improve urethral sphincter function. Pre-procedure evaluation includes a focused history, physical exam, urinalysis to exclude infection, and urodynamic testing or cystoscopy results documenting sphincteric deficiency. On the day of service, the patient is placed in lithotomy position; the provider harvests a small skeletal muscle biopsy (often from the thigh), processes the tissue to isolate and expand muscle progenitor cells per protocol, and injects the patient’s own cells into the external urethral sphincter under direct visualization using cystoscopy and/or transperineal ultrasound guidance. Local anesthesia with or without sedation is used; monitoring and standard sterile technique are maintained. Post-procedure instructions address activity restrictions, voiding diary, and follow-up to assess continence and potential need for repeat treatment. Typical site of service is an outpatient ambulatory surgery center or hospital outpatient department; this is a procedure performed by specialists in urology, Female Pelvic Medicine and Reconstructive Surgery, or reconstructive pelvic medicine programs.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    52000Cystourethroscopy, with or without collection of specimen(s) by brushing or washing, when performedDiagnostic cystoscopy performed before or during injection to visualize the urethral sphincter

    51798 | Measurement of post-void residual urine and/or bladder capacity by catheterization and/or ultrasound, single determination | Pre- or post-procedure assessment of bladder emptying and residual volume

    51784 | Complex uroflowmetry, with or without electromyography (EMG) | Urodynamic assessment used in pre-procedure evaluation of sphincter function

    20610 | Arthrocentesis, aspiration and/or injection; major joint or bursa (e.g., shoulder, hip, knee) — included here as a similar injection technique code for local anesthetic or guidance techniques (note: not for billing this procedure) | Technique correlation: demonstrates principles of injection technique and local anesthesia administration

    76942 | Ultrasonic guidance for needle placement (e.g., biopsy, aspiration, injection), imaging supervision and interpretation | Used when transperineal or transvaginal ultrasound guidance is used to guide injections into the sphincter

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    25CPT modifier 25 indicates that on the same day as another procedure or service, the same physician or other qualified health care professional provided a significant, separately identifiable…- When to apply: Use modifier 25 only on an E/M code to indicate the same provider delivered a significant, separately identifiable E/M service on the same day as another procedure or service — i.e.,…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208800000X
    207V00000X
    208000000X
    208U00000X
    174400000X
    3140N1450X
    207RN0300X
    261QX0200X

    Related ICD-10-CM Codes

    24 rows

    ICD-10-CM CodeDescription
    F52.21Male erectile disorder
    I83.90Asymptomatic varicose veins of unspecified lower extremity
    M62.81Muscle weakness (generalized)
    M62.838Other muscle spasm
    N31.1Reflex neuropathic bladder, not elsewhere classified
    N31.9Neuromuscular dysfunction of bladder, unspecified
    N32.89Other specified disorders of bladder
    N32.9Bladder disorder, unspecified
    N36.1Urethral diverticulum
    N36.9Urethral disorder, unspecified

    Showing 1–10 of 24

    Related Payer Policy Updates

    Specialty: Orthopedics/Musculoskeletal1 / 3

    10 rows

    PolicyPayerEffective Date
    Orthopedic Joint Procedures of the Knee for Managed Medicaid (MMC), Health and Recovery Plan (HARP), Child Health Plus (CHP), and Essential Plan (EP) Membersuniverahealthcare2027-01-01
    Autologous Chondrocyte Transplantation or Implantation Corporate Medical Policybcbsvermont2026-12-01
    Autologous Platelet-Derived Growth Factors (Platelet-Rich Plasma [PRP])Cigna2026-10-15
    Metatarsophalangeal Joint ReplacementCigna2026-10-15
    Shoulder Arthroplasty (Total, Partial, Reverse, Revision and Resurfacing)univerahealthcare2026-10-15
    Hip Arthroplasty (partial and total hip replacement)univerahealthcare2026-10-15
    Artificial Lumbar Intervertebral Disc (Lumbar Total Disc Arthroplasty)univerahealthcare2026-10-15
    Osteochondral Grafting of the Kneeuniverahealthcare2026-10-15
    Metal-on-Metal Total Hip Resurfacinguniverahealthcare2026-10-15
    Lumbar Fusion (arthrodesis) with decompressionuniverahealthcare2026-10-15

    Related Codes

    CPT-0999T-AUTOLOGOUS-MUSCLE-PROGENITOR-CELL-COLLECTION

    CPT 0999T: Muscle Progenitor Cell Collection

    CPT-1001T-AUTOLOGOUS-MUSCLE-PROGENITOR-INJECTION-ANAL-SPHINCTER

    CPT 1001T: Injection of Muscle Progenitor Cells into External Anal Sphincter

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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