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    v1.0.30
    OpenPayerBilling CodesAutologous Muscle Cell Therapy ProceduresCPT cpt-1001t-autologous-muscle-progenitor-injection-anal-sphincter
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    CPT 1001T: Injection of Muscle Progenitor Cells into External Anal Sphincter

    CPT code 1001T describes injection of a patient’s own muscle progenitor cells into the external anal sphincter to improve sphincter muscle function; the service is a regenerative cell therapy procedure typically performed in an outpatient procedural or ambulatory surgery setting and may use ultrasound guidance for injection placement.

    For related coverage guidance, see recent payer policy updates: Orthopedic Joint Procedures of the Knee for Managed Medicaid (MMC), Health and Recovery Plan (HARP), Child Health Plus (CHP), and Essential Plan (EP) Members, Autologous Chondrocyte Transplantation or Implantation Corporate Medical Policy, Autologous Platelet-Derived Growth Factors (Platelet-Rich Plasma [PRP]).

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    Clinical & Coding Specifications

    Clinical Context

    A 58-year-old female with postpartum-related fecal incontinence presents to a colorectal specialist after conservative measures (pelvic floor physical therapy, biofeedback, and continence medications) fail to improve symptoms. The evaluation includes anorectal manometry, endoanal ultrasound, and clinical exam confirming external anal sphincter weakness with preserved pudendal nerve function. The provider discusses autologous muscle progenitor cell injection into the external anal sphincter to improve sphincter contractility.

    Procedure workflow: The patient arrives to an ambulatory surgical center or hospital outpatient department. After informed consent, the provider harvests a small muscle biopsy (often from the thigh) in a separate minor procedure or as part of a prior visit; muscle progenitor cells are expanded in a laboratory. On the day of injection, the patient is positioned in the lithotomy or prone jackknife position. Under local anesthesia with or without sedation, the provider uses digital guidance and may use endoanal or transperineal ultrasound for needle localization. Multiple small-volume injections of the patient’s autologous muscle progenitor cells are delivered into the external anal sphincter to augment muscle bulk and contractile function. The patient is observed briefly for immediate complications (bleeding, pain, infection) and discharged with instructions for activity modification and follow-up assessments including repeat anorectal manometry and continence scoring over months to assess functional improvement.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    56260Fecal incontinence procedures, injection of bulking agent into the submucosal or intersphincteric space of the anal canalAlternative or adjunctive injection therapy for fecal incontinence; may be performed in similar clinical settings when bulking agents are used instead of cell therapy
    51784Sling operation for stress incontinence (urethral) using natural tissue graftDifferent anatomic focus (urinary vs anal) but represents pelvic floor reconstructive procedures that may be performed in patients with combined pelvic floor disorders
    57425Colposcopy with biopsy or endocervical curettageExample of other outpatient pelvic procedures that may be performed in the same ambulatory surgical setting; not directly related but relevant for scheduling/resource use
    76937Ultrasound, guidance for needle placement (e.g., biopsy, aspiration, injection), real-timeCommonly reported when ultrasound guidance is used to localize the external anal sphincter during injection of muscle progenitor cells
    99213Office or other outpatient visit for the evaluation and management of an established patientTypical E/M code used for pre-procedure consultation or post-procedure follow-up visits in the outpatient setting

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    25CPT modifier 25 indicates that on the same day as another procedure or service, the same physician or other qualified health care professional provided a significant, separately identifiable…- When to apply: Use modifier 25 only on an E/M code to indicate the same provider delivered a significant, separately identifiable E/M service on the same day as another procedure or service — i.e.,…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    57CPT® modifier -57 (“Decision for Surgery”) is appended to an Evaluation and Management (E/M) service when that encounter results in the initial decision to perform a major surgery (a procedure with a…- Use modifier 57 when an E/M service provided by the same provider (or same tax ID) on the day of or the day before a major surgical procedure (90‑day global period) results in the initial decision…
    24Modifier 24 denotes an unrelated evaluation and management (E/M) service performed by the same physician or qualified healthcare professional during a postoperative global period. Per CPT guidance,…- Use modifier 24 when you report an evaluation and management (E/M) service performed by the same physician or same-specialty group during a procedure’s postoperative global period that is unrelated…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    2080P0206X
    2086S0105X
    207L00000X
    2084P0800X
    2085R0202X
    163WG0100X
    152WP0200X
    224ZR0403X

    Related ICD-10-CM Codes

    25 rows

    ICD-10-CM CodeDescription
    F98.4Stereotyped movement disorders
    G47.33Obstructive sleep apnea (adult) (pediatric)
    G83.4Cauda equina syndrome
    G83.89Other specified paralytic syndromes
    G83.9Paralytic syndrome, unspecified
    I83.90Asymptomatic varicose veins of unspecified lower extremity
    K59.1Functional diarrhea
    K59.2Neurogenic bowel, not elsewhere classified
    K59.9Functional intestinal disorder, unspecified
    K64.9Unspecified hemorrhoids

    Showing 1–10 of 25

    Related Payer Policy Updates

    Specialty: Orthopedics/Musculoskeletal1 / 3

    10 rows

    PolicyPayerEffective Date
    Orthopedic Joint Procedures of the Knee for Managed Medicaid (MMC), Health and Recovery Plan (HARP), Child Health Plus (CHP), and Essential Plan (EP) Membersuniverahealthcare2027-01-01
    Autologous Chondrocyte Transplantation or Implantation Corporate Medical Policybcbsvermont2026-12-01
    Autologous Platelet-Derived Growth Factors (Platelet-Rich Plasma [PRP])Cigna2026-10-15
    Metatarsophalangeal Joint ReplacementCigna2026-10-15
    Shoulder Arthroplasty (Total, Partial, Reverse, Revision and Resurfacing)univerahealthcare2026-10-15
    Hip Arthroplasty (partial and total hip replacement)univerahealthcare2026-10-15
    Artificial Lumbar Intervertebral Disc (Lumbar Total Disc Arthroplasty)univerahealthcare2026-10-15
    Osteochondral Grafting of the Kneeuniverahealthcare2026-10-15
    Metal-on-Metal Total Hip Resurfacinguniverahealthcare2026-10-15
    Lumbar Fusion (arthrodesis) with decompressionuniverahealthcare2026-10-15

    Related Codes

    CPT-0999T-AUTOLOGOUS-MUSCLE-PROGENITOR-CELL-COLLECTION

    CPT 0999T: Muscle Progenitor Cell Collection

    CPT-1000T-URETHRAL-SPHINCTER-MUSCLE-PROGENITOR-CELL-INJECTION

    CPT 1000T: Urethral Sphincter Muscle Progenitor Cell Injection

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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