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    OpenPayerBilling CodesPercutaneous Cryoablation ProceduresCPT cpt-0441t-distal-lower-extremity-nerve-cryoablation
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    CPT 0441T: Cryoablation of Distal Lower Extremity Peripheral Nerve

    CPT code 0441T describes use of cryoablation to apply freezing temperatures to destroy a distal or peripheral nerve near the end of the lower extremity for treatment of complex regional pain syndrome or other neuropathy; this is a minimally invasive nerve ablation procedure typically performed as an interventional pain management service in an outpatient surgical center, ambulatory clinic, or hospital outpatient department under image guidance and local/regional anesthesia.

    For related coverage guidance, see recent payer policy updates: Intraosseous Basivertebral Nerve Ablation for Child Health Plus (CHP) and Essential Plan (EP) Members, Acupuncture Services Payment Policy, Drug Testing in Pain Management and Substance Use Disorder.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 46-year-old patient with longstanding complex regional pain syndrome (CRPS) of the distal lower extremity presents to an outpatient interventional pain clinic after failure of conservative measures including physical therapy, oral neuropathic agents, and peripheral nerve blocks. The patient reports focal, neuropathic pain localized to the dorsum of the foot and toes with allodynia and decreased function. Prior diagnostic peripheral nerve block of the implicated distal sensory nerve produced significant, but transient, pain relief. The interventionalist discusses cryoablation of the distal/peripheral nerve near the end of the lower extremity to provide longer-duration analgesia.

    The clinical workflow includes preprocedural evaluation and informed consent, review of prior imaging and nerve block response, procedural planning for the targeted distal nerve (ultrasound or fluoroscopic guidance as indicated), sterile field preparation, local anesthesia, application of cryoablation probe to the distal/peripheral nerve, monitoring for immediate complications, and postprocedural recovery with discharge instructions. Follow-up visits assess pain relief, functional improvement, and potential adverse effects such as sensory deficit or infection.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    64450Injection, anesthetic agent; other peripheral nerve or branchDiagnostic or therapeutic peripheral nerve block used prior to cryoablation to confirm target nerve and predict response.
    76942Ultrasonic guidance for needle placement (eg, diagnostic or therapeutic injection, aspiration or drainage)Ultrasound guidance often used to visualize distal peripheral nerves and guide cryoablation probe placement.
    77002Fluoroscopic guidance for needle placement (radiological supervision and interpretation)Fluoroscopic guidance when imaging is needed to localize bony landmarks for distal nerve targeting.
    99213Office or other outpatient visit for evaluation and management, typically 15 minutesPreprocedural and postprocedural follow-up visits for assessment and management related to the cryoablation.
    99024Postoperative follow-up visit, included in global periodUse for routine postoperative follow-up when included in the global surgical package for related procedures.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207L00000X
    207K00000X
    2084P0800X
    208000000X
    207SG0207X
    207UN0903X
    163WG0600X
    103TP0814X

    Related ICD-10-CM Codes

    22 rows

    ICD-10-CM CodeDescription
    E10.621Type 1 diabetes mellitus with foot ulcer
    E11.42Type 2 diabetes mellitus with diabetic polyneuropathy
    E11.621Type 2 diabetes mellitus with foot ulcer
    F45.41Pain disorder exclusively related to psychological factors
    G54.6Phantom limb syndrome with pain
    G56.41Causalgia of right upper limb
    G57.51Tarsal tunnel syndrome, right lower limb
    G57.61Lesion of plantar nerve, right lower limb
    G58.8Other specified mononeuropathies
    G60.0Hereditary motor and sensory neuropathy

    Showing 1–10 of 22

    Related Payer Policy Updates

    Specialty: Pain Management1 / 3

    10 rows

    PolicyPayerEffective Date
    Intraosseous Basivertebral Nerve Ablation for Child Health Plus (CHP) and Essential Plan (EP) Membersuniverahealthcare2027-01-01
    Acupuncture Services Payment Policyfallon_community_health_plan_inc2026-12-01
    Drug Testing in Pain Management and Substance Use Disorderbcbsvermont2026-11-01
    Lysis of Epidural Adhesionsexcellus_health_plan_inc2026-10-15
    Intradiscal Proceduresexcellus_health_plan_inc2026-10-15
    Facet Joint Injections/ Medial Branch Blocksuniverahealthcare2026-10-15
    Radiofrequency Facet and Sacroiliac Joint Ablation/ Denervationuniverahealthcare2026-10-15
    Epidural Steroid Injections / Selective Nerve Root Block (SNRB)univerahealthcare2026-10-15
    Lysis of Epidural Adhesions (Epidural Adhesiolysis)univerahealthcare2026-10-15
    Prolotherapyuniverahealthcare2026-10-15

    Related Codes

    CPT-0440T-UPPER-EXTREMITY-PERIPHERAL-NERVE-CRYOABLATION

    CPT 0440T: Cryoablation of Distal Peripheral Nerve, Upper Extremity

    CPT-0442T-CRYOABLATION-NERVE-PLEXUS-TRUNK-PUDENDUM

    CPT 0442T: Cryoablation of Trunk or Pudendal Nerve Plexus

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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