Headline: CPT code 0377U covers Liposcale®, an NMR-based lipoprotein profiling test that reports 23 variables of lipid particle size and number. Lead: CPT code 0377U designates a proprietary laboratory analysis (PLA) for Liposcale® from CIMA Sciences LLC, an advanced nuclear magnetic resonance (NMR) spectroscopy assay that produces a detailed lipoprotein profile from serum or plasma and may better predict adverse cardiovascular events.

Why it matters nationally: Advanced lipid particle profiling affects cardiovascular risk stratification and could influence diagnostic pathways, specialist referrals, and lab utilization across the country. As a PLA code tied to a single manufacturer, CPT code 0377U has implications for test identification, billing transparency, and payer coverage policy.

Key payers covered: Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare are included in the payer overview.

What readers will learn: The publication provides benchmarks and coverage context for CPT code 0377U, explains the clinical context of NMR-based lipoprotein testing, and summarizes how the proprietary nature of the PLA code affects billing and traceability. It also highlights common billing modifiers and notes where input data are not available. The goal is to inform billing staff, laboratory managers, and policy analysts about the code’s purpose, service setting, and relevance to cardiovascular risk assessment.