CPT 0001U: PreciseType HEA Erythrocyte Antigen Genotyping

CPT code 0001U describes the Immucor PreciseType® HEA Test, a Proprietary Laboratory Analyses (PLA) multiplexed molecular assay performed on a whole blood specimen to identify 24 polymorphisms associated with 35 human erythrocyte antigens from 11 blood groups and report common RBC alleles; service type: molecular diagnostic genotyping for erythrocyte antigen determination; typical site of service: outpatient laboratory or hospital clinical laboratory performing specialized molecular testing.

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CPT 0001U: PreciseType HEA Erythrocyte Antigen Genotyping

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Get alerted when payer policies referencing 0001U are released or updated.

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Clinical & Coding Specifications

Clinical Context

A 34-year-old pregnant patient with a history of prior transfusion and a positive antibody screen is referred for molecular red blood cell (RBC) antigen typing to guide transfusion planning and prenatal care. A venous whole blood specimen is collected and sent to a reference laboratory for the Immucor PreciseType® HEA Test 0001U, a multiplexed molecular assay that detects 24 polymorphisms corresponding to 35 erythrocyte antigens across 11 blood groups. The laboratory performs specimen accessioning, DNA extraction, multiplex PCR and allele detection, analytic interpretation, and issues a report documenting the presence or absence of common RBC alleles. Results inform selection of antigen-negative donor units for transfusion, management of hemolytic disease of the fetus and newborn risk, and resolution of serologic discrepancies. Typical sites of service include outpatient phlebotomy centers, hospital blood banks, prenatal clinics, and reference molecular laboratories. The specimen workflow often follows: provider order → patient consent and blood draw → courier transport to molecular lab → processing and testing under controlled conditions → medical technologist validation and pathologist sign-out → electronic report to ordering clinician and transfusion service.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`80055`	Hepatic function panel	Ancillary chemistry tests sometimes ordered concurrently in comprehensive pretransfusion or prenatal evaluation

36415 | Collection of venous blood by venipuncture | Blood draw procedure used to obtain the whole blood specimen for the 0001U molecular assay

86850 | Antibody identification; RBC | Serologic antibody identification that may precede or complement molecular RBC antigen testing for transfusion planning

86900 | Compatibility testing, crossmatch, serologic | Crossmatch testing performed when donor units are selected based on molecular results

87880 | Infectious agent detection by nucleic acid (e.g., viral RNA), amplified probe technique | Representative molecular test category; not specific but aligns with lab molecular workflow and instrumentation

Related Modifiers

5 rows

Modifier	Description	When to Use
26	Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…	- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
53	Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…	- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
59	Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…	- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
90	Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…	- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207Q00000X	Family Medicine Physician	Family Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
207LP2900X	Pain Medicine (Anesthesiology) Physician	An anesthesiologist who provides a high level of care, either as a primary physician or consultant, for patients experiencing problems with acute, chr…
363A00000X	Physician Assistant	A physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
367A00000X	Advanced Practice Midwife	Advanced practice midwifery encompasses the independent provision of care during pregnancy, childbirth, and the postpartum period; sexual and reproduc…
2470A2800X	Assistant Health Information Record Technician	None
246QB0000X	Blood Banking Specialist/Technologist	Technologists, Technicians & Other Technical Service Providers · Specialist/Technologist, Pathology
261QM1102X	Military Outpatient Operational (Transportable) Component Clinic/Center	"Non-fixed" facilities or distinct parts of a "non-fixed" facility, providing outpatient medical and dental services, primarily intended for DoD activ…
2081S0010X	Sports Medicine (Physical Medicine & Rehabilitation) Physician	A physician who specializes in Sports Medicine is responsible for continuous care related to the enhancement of health and fitness as well as the prev…

CPT 0002U: PolypDX™ Urine Metabolomic Risk Assay

CPT-0003U-OVAR-A-NEXT-GENERATION-OVARIAN-CANCER-RISK-ASSAY

CPT 0003U: Overa (MIA2G) Ovarian Cancer Risk Assay

CPT-0005U-PROSTATE-EXOSOMEDX-INTELLISCORE-GENE-EXPRESSION-URINE-TEST

CPT 0005U: ExosomeDx Prostate (IntelliScore) urine gene expression test

CPT-0007U-TOXPROTECT-URINE-DRUG-SCREEN-WITH-DNA-AUTHENTICATION

CPT 0007U: ToxProtect Urine Drug Screen With DNA Authentication

CPT-0008U-H-PYLORI-ANTIBIOTIC-RESISTANCE-SEQUENCING-PANEL

CPT 0008U: H. pylori Antibiotic Resistance Gene Panel

CPT-0009U-DEPARRAY-HER2-FISH-TUMOR-CELL-ISOLATION

CPT 0009U: DEPArray HER2 Tumor‑Cell Isolation with FISH Analysis

CPT-0010U-BACTERIAL-TYPING-WHOLE-GENOME-SEQUENCING-MAYO-CLINIC

CPT 0010U: Bacterial Typing by Whole Genome Sequencing, Mayo Clinic

CPT-0011U-CORDANT-CORE-ALGORITHMIC-ORAL-FLUID-DRUG-TEST

CPT 0011U: Oral Fluid Drug Test with Algorithmic Steady‑State Comparison

CPT-0016U-BCR-ABL1-MAJOR-MINOR-FUSION-TRANSCRIPT-TESTING

CPT 0016U: BCR–ABL1 Major and Minor Breakpoint Fusion Transcripts

CPT-0017U-JAK2-MUTATION-UNIVERSITY-OF-IOWA

CPT 0017U: JAK2 Mutation Sequencing, University of Iowa

Showing 1–10 of 536

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

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Clinical & Coding Specifications

Clinical Context

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`80055`	Hepatic function panel	Ancillary chemistry tests sometimes ordered concurrently in comprehensive pretransfusion or prenatal evaluation

36415 | Collection of venous blood by venipuncture | Blood draw procedure used to obtain the whole blood specimen for the 0001U molecular assay

86850 | Antibody identification; RBC | Serologic antibody identification that may precede or complement molecular RBC antigen testing for transfusion planning

86900 | Compatibility testing, crossmatch, serologic | Crossmatch testing performed when donor units are selected based on molecular results

Related Modifiers

5 rows

Modifier	Description	When to Use
26	Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…	- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
53	Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…	- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
59	Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…	- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
90	Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…	- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207Q00000X	Family Medicine Physician	Family Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
207LP2900X	Pain Medicine (Anesthesiology) Physician	An anesthesiologist who provides a high level of care, either as a primary physician or consultant, for patients experiencing problems with acute, chr…
363A00000X	Physician Assistant	A physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
367A00000X	Advanced Practice Midwife	Advanced practice midwifery encompasses the independent provision of care during pregnancy, childbirth, and the postpartum period; sexual and reproduc…
2470A2800X	Assistant Health Information Record Technician	None
246QB0000X	Blood Banking Specialist/Technologist	Technologists, Technicians & Other Technical Service Providers · Specialist/Technologist, Pathology
261QM1102X	Military Outpatient Operational (Transportable) Component Clinic/Center	"Non-fixed" facilities or distinct parts of a "non-fixed" facility, providing outpatient medical and dental services, primarily intended for DoD activ…
2081S0010X	Sports Medicine (Physical Medicine & Rehabilitation) Physician	A physician who specializes in Sports Medicine is responsible for continuous care related to the enhancement of health and fitness as well as the prev…

CPT 0002U: PolypDX™ Urine Metabolomic Risk Assay

CPT-0003U-OVAR-A-NEXT-GENERATION-OVARIAN-CANCER-RISK-ASSAY

CPT 0003U: Overa (MIA2G) Ovarian Cancer Risk Assay

CPT-0005U-PROSTATE-EXOSOMEDX-INTELLISCORE-GENE-EXPRESSION-URINE-TEST

CPT 0005U: ExosomeDx Prostate (IntelliScore) urine gene expression test

CPT-0007U-TOXPROTECT-URINE-DRUG-SCREEN-WITH-DNA-AUTHENTICATION

CPT 0007U: ToxProtect Urine Drug Screen With DNA Authentication

CPT-0008U-H-PYLORI-ANTIBIOTIC-RESISTANCE-SEQUENCING-PANEL

CPT 0008U: H. pylori Antibiotic Resistance Gene Panel

CPT-0009U-DEPARRAY-HER2-FISH-TUMOR-CELL-ISOLATION

CPT 0009U: DEPArray HER2 Tumor‑Cell Isolation with FISH Analysis

CPT-0010U-BACTERIAL-TYPING-WHOLE-GENOME-SEQUENCING-MAYO-CLINIC

CPT 0010U: Bacterial Typing by Whole Genome Sequencing, Mayo Clinic

CPT-0011U-CORDANT-CORE-ALGORITHMIC-ORAL-FLUID-DRUG-TEST

CPT 0011U: Oral Fluid Drug Test with Algorithmic Steady‑State Comparison

CPT-0016U-BCR-ABL1-MAJOR-MINOR-FUSION-TRANSCRIPT-TESTING

CPT 0016U: BCR–ABL1 Major and Minor Breakpoint Fusion Transcripts

CPT-0017U-JAK2-MUTATION-UNIVERSITY-OF-IOWA

CPT 0017U: JAK2 Mutation Sequencing, University of Iowa

Showing 1–10 of 536

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

OpenPayer

CPT 0001U: PreciseType HEA Erythrocyte Antigen Genotyping

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OpenPayer

CPT 0001U: PreciseType HEA Erythrocyte Antigen Genotyping

Sign up for cpt 0001U policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

References

CPT 0001U: PreciseType HEA Erythrocyte Antigen Genotyping

Sign up for cpt 0001U policy alerts

CPT 0001U: PreciseType HEA Erythrocyte Antigen Genotyping

Sign up for cpt 0001U policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

What does CPT code 0001U represent?

In what clinical situations is the PreciseType HEA test used?

What is the specimen and laboratory workflow for testing under code 0001U?

Which other CPT tests or procedures are commonly associated with 0001U?

What diagnoses or clinical codes are related to use of the PreciseType HEA assay?

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

What does CPT code 0001U represent?

In what clinical situations is the PreciseType HEA test used?

What is the specimen and laboratory workflow for testing under code 0001U?

Which other CPT tests or procedures are commonly associated with 0001U?

What diagnoses or clinical codes are related to use of the PreciseType HEA assay?

References