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    OpenPayerBilling CodesMalignant neoplasms of urinary tractICD-10-CM c66-malignant-neoplasm-of-ureter
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    ICD-10-CM Code For Malignant Neoplasm Of Ureter: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group C66 includes malignant neoplasms originating in the ureter, covering primary ureteral cancers and specified laterality when documented. These ICD-10-CM diagnosis codes are used to document clinical encounters for diagnosis, treatment planning, and monitoring of tumor involvement of the ureter, capturing site specificity and laterality. Accurate coding within the ICD-10-CM C66 group supports proper claim adjudication.

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    ICD-10-CM C66: Malignant Neoplasm Of Ureter Overview

    The ICD-10-CM C66 diagnosis group represents malignant tumors arising in the ureter, part of the urinary tract that connects the kidney to the bladder. These codes target neoplastic conditions of the ureter and surrounding urinary structures and are used across oncology, urology, and pathology documentation. Accurate coding is important for reflecting disease site and extent, supporting appropriate claim adjudication and clinical data integrity.

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    When to Use

    Use a code from this group when a patient has a documented malignant neoplasm located in the ureter and the clinical record specifies laterality or other distinguishing features. These codes are applied for encounters involving diagnosis, treatment, surveillance, or staging related to ureteral cancer.

    ICD-10-CM Codes

    3 rows

    ICD-10-CM CodeDescription
    C66.1Malignant neoplasm of right ureter
    C66.2Malignant neoplasm of left ureter
    C66.9Malignant neoplasm of unspecified ureter

    DRG Codes

    6 rows

    DRG CodeDescription
    656Kidney and Ureter Procedures for Neoplasm with MCC
    657Kidney and Ureter Procedures for Neoplasm with CC
    658Kidney and Ureter Procedures for Neoplasm without CC/MCC
    686Kidney and Urinary Tract Neoplasms with MCC
    687Kidney and Urinary Tract Neoplasms with CC
    688Kidney and Urinary Tract Neoplasms without CC/MCC

    Typical Clinical Scenarios

    • An elderly patient presents to the emergency department with sudden onset of severe flank pain and gross hematuria; CT urogram reveals an enhancing mass within the distal ureter causing hydronephrosis. The acute presentation with imaging-confirmed malignant ureteral tumor explains the obstruction and bleeding, so a malignant ureter neoplasm code is assigned. Typical codes: C66.2
    • A middle-aged patient with progressive, unexplained microscopic hematuria undergoes ureteroscopy and biopsy that demonstrate invasive urothelial carcinoma of the proximal ureter; staging studies show no distant metastasis. This outpatient diagnostic path for a confirmed malignant ureter lesion leads to assignment of the specific site code for the proximal ureter. Typical codes: C66.1
    • A patient with a history of bladder cancer now develops flank pain and imaging demonstrates a recurrent malignant lesion involving the ureterovesical junction with local extension and recurrent hematuria requiring palliative nephrostomy. In this scenario of recurrence/extension to the distal ureter as a complication of prior malignancy, a distal ureter malignant neoplasm code is used to capture the current site of disease. Typical codes: C66.2, C66.9

    Related Codes

    C64-MALIGNANT-NEOPLASM-OF-KIDNEY

    ICD-10-CM Code For Malignant Neoplasm Of Kidney Except Renal Pelvis: Group Overview

    C65-MALIGNANT-NEOPLASM-OF-RENAL-PELVIS

    ICD-10-CM Code For Malignant Neoplasm Of Renal Pelvis: Group Overview

    C67-MALIGNANT-NEOPLASM-OF-BLADDER

    ICD-10-CM Code For Malignant Neoplasm Of Bladder: Group Overview

    C68-MALIGNANT-NEOPLASM-URINARY-ORGANS

    ICD-10-CM Code For Malignant Neoplasm Of Other And Unspecified Urinary Organs: Group Overview

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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