ICD-10-CM Code For Nonvenereal Syphilis: Group Overview

The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group A65 includes diagnoses of nonvenereal syphilis such as endemic syphilis and pinta, covering treponemal skin and mucocutaneous infections not caused by sexual transmission. These ICD-10-CM diagnosis codes are used to document clinical encounters where treponemal infection is identified, capturing disease manifestations, affected anatomical sites, and any complications. Accurate coding within the ICD-10-CM A65 group supports proper claim adjudication and complete clinical documentation for appropriate reimbursement.

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ICD-10-CM A65: Nonvenereal Syphilis Overview

The ICD-10-CM A65 group represents nonvenereal syphilis, a category of spirochetal infections that are not sexually transmitted. These diagnoses target systemic infection by treponemal organisms affecting skin, mucous membranes, and potentially other organs. Accurate coding matters for complete clinical documentation and supports proper reimbursement for services related to diagnosis and treatment.

When to Use

Use a code from this group when documentation indicates a diagnosis of nonvenereal treponemal infection such as endemic syphilis or pinta. Select the most specific code that reflects the documented site, disease stage, and any associated complications.

ICD-10-CM Codes

1 rows

ICD-10-CM Code	Description
A65	Nonvenereal syphilis

DRG Codes

3 rows

DRG Code	Description
867	Other Infectious and Parasitic Diseases Diagnoses with MCC
868	Other Infectious and Parasitic Diseases Diagnoses with CC
869	Other Infectious and Parasitic Diseases Diagnoses without CC/MCC

Typical Clinical Scenarios

A middle-aged patient presents to the sexual health clinic with a painless chancre on the penis and regional non-tender lymphadenopathy after a known exposure; dark-field microscopy confirms Treponema pallidum and the clinician documents primary nonvenereal syphilis acquired through nonsexual contact. This scenario represents an acute, localized presentation prompting diagnostic testing and treatment initiation, and a code from this group is assigned to capture the specific nonvenereal spirochetal infection. Typical codes: A65
An elderly patient with a slowly progressive skin eruption of copper-colored maculopapular lesions on the trunk and palms, along with a history suggestive of untreated infection for months, presents to dermatology for evaluation; serologic testing and clinical exam support a diagnosis of secondary nonvenereal syphilis. This chronic-ongoing clinical presentation requires assigning a code from this group to reflect the systemic spirochetal disease stage and guide public health reporting. Typical codes: A65
A pediatric patient is evaluated in the hospital for neurologic signs including headache and cranial nerve palsy following suspected congenital or perinatally acquired spirochetal infection; neurology documents findings consistent with late complications of nonvenereal syphilis requiring inpatient management and coordination with infectious disease. In the setting of a complication or comorbidity from the spirochetal infection, a code from this group is used to capture the underlying causative diagnosis. Typical codes: A65

Related Codes

A66-YAWS

ICD-10-CM Code For Yaws: Group Overview

A67-PINTA-CARATE

ICD-10-CM Code For Pinta Carate: Group Overview

A68-RELAPSING-FEVERS

ICD-10-CM Code For Relapsing Fevers: Group Overview

A69-OTHER-SPIROCHETAL-INFECTIONS

ICD-10-CM Code For Other Spirochetal Infections: Group Overview

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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When to Use

ICD-10-CM Codes

1 rows

ICD-10-CM Code	Description
A65	Nonvenereal syphilis

DRG Codes

3 rows

DRG Code	Description
867	Other Infectious and Parasitic Diseases Diagnoses with MCC
868	Other Infectious and Parasitic Diseases Diagnoses with CC
869	Other Infectious and Parasitic Diseases Diagnoses without CC/MCC

Typical Clinical Scenarios

A middle-aged patient presents to the sexual health clinic with a painless chancre on the penis and regional non-tender lymphadenopathy after a known exposure; dark-field microscopy confirms Treponema pallidum and the clinician documents primary nonvenereal syphilis acquired through nonsexual contact. This scenario represents an acute, localized presentation prompting diagnostic testing and treatment initiation, and a code from this group is assigned to capture the specific nonvenereal spirochetal infection. Typical codes: A65
An elderly patient with a slowly progressive skin eruption of copper-colored maculopapular lesions on the trunk and palms, along with a history suggestive of untreated infection for months, presents to dermatology for evaluation; serologic testing and clinical exam support a diagnosis of secondary nonvenereal syphilis. This chronic-ongoing clinical presentation requires assigning a code from this group to reflect the systemic spirochetal disease stage and guide public health reporting. Typical codes: A65
A pediatric patient is evaluated in the hospital for neurologic signs including headache and cranial nerve palsy following suspected congenital or perinatally acquired spirochetal infection; neurology documents findings consistent with late complications of nonvenereal syphilis requiring inpatient management and coordination with infectious disease. In the setting of a complication or comorbidity from the spirochetal infection, a code from this group is used to capture the underlying causative diagnosis. Typical codes: A65

Related Codes

A66-YAWS

ICD-10-CM Code For Yaws: Group Overview

A67-PINTA-CARATE

ICD-10-CM Code For Pinta Carate: Group Overview

A68-RELAPSING-FEVERS

ICD-10-CM Code For Relapsing Fevers: Group Overview

A69-OTHER-SPIROCHETAL-INFECTIONS

ICD-10-CM Code For Other Spirochetal Infections: Group Overview

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

ICD-10-CM Code For Nonvenereal Syphilis: Group Overview

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ICD-10-CM A65: Nonvenereal Syphilis Overview

ICD-10-CM Code For Nonvenereal Syphilis: Group Overview

Sign up for ICD-10-CM Code For Nonvenereal Syphilis: Group Overview policy alerts

ICD-10-CM A65: Nonvenereal Syphilis Overview

When to Use

ICD-10-CM Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

What diagnoses are included in ICD-10-CM group A65?

Which specific ICD-10-CM code represents nonvenereal syphilis?

How does accurate coding in the A65 group affect claims and documentation?

Which DRGs may be related to cases coded with `A65`?

What clinical settings or manifestations does the A65 group target?

References

When to Use

ICD-10-CM Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

What diagnoses are included in ICD-10-CM group A65?

Which specific ICD-10-CM code represents nonvenereal syphilis?

How does accurate coding in the A65 group affect claims and documentation?

Which DRGs may be related to cases coded with `A65`?

What clinical settings or manifestations does the A65 group target?

References