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    v1.0.28
    OpenPayerBilling CodesDiseases and Disorders of the Female Reproductive SystemDRG 757-infections-female-reproductive-system-with-mcc
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    Infections, Female Reproductive System with MCC: Inpatient Reimbursement Overview

    DRG 757 encompasses infections of the female reproductive system with a Major Complication or Comorbidity that increase clinical severity and resource use. This Diagnosis-Related Group is important for inpatient reimbursement because the Major Complication or Comorbidity elevates payment relative to lower-severity groups.

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    DRG 757 Overview

    DRG 757 covers hospital admissions for infections of the female reproductive system when a Major Complication or Comorbidity is present, including severe pelvic inflammatory disease with systemic involvement or other serious infectious complications. This Diagnosis-Related Group matters for Medicare payment because the presence of a Major Complication or Comorbidity typically increases the relative resource intensity and the inpatient prospective payment. Accurate clinical documentation and coding that capture the infection and the Major Complication or Comorbidity are central to assigning this Diagnosis-Related Group and determining payment levels.

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    Clinical Trials

    • Acute antimicrobial management trials: randomized or pragmatic studies comparing different empiric antimicrobial strategies, dosing regimens, or durations for severe pelvic or reproductive tract infections with major complications (eg, sepsis, pelvic abscess, necrosis). These trials enroll hospitalized adult women with confirmed infections of the uterus, adnexa, or pelvic soft tissues who meet criteria for major complication or comorbidity (MCC), and they examine endpoints such as time to clinical stability, need for surgical source control, ICU transfer, and in-hospital mortality. Results inform inpatient antibiotic stewardship, resource use (eg, length of stay, ICU days), and payer decisions about coverage of newer or higher-cost antimicrobial options during acute episodes.
    • Comparative effectiveness and surgical versus medical management studies: observational cohorts or randomized trials comparing outcomes of conservative medical therapy versus procedural or surgical interventions (eg, percutaneous drainage, laparoscopic debridement, hysterectomy) for complicated reproductive tract infections complicated by abscesses, torsion risk, or hemorrhage. Studies focus on adult patients with infections classified under this DRG who present with MCC-level severity, measuring composite outcomes like reoperation rates, complication burden, readmission, and post-procedure functional status. Findings are directly relevant to clinicians choosing initial management strategies and to payers evaluating the relative cost-effectiveness of operative care pathways versus prolonged medical management in high-acuity inpatient populations.
    • Post-discharge outcomes and care-transition research: prospective cohort studies and quality-improvement trials assessing post-discharge morbidity, readmission drivers, adherence to follow-up, and outpatient antibiotic or wound care needs among survivors of complicated female reproductive system infections with MCC. These investigations enroll patients discharged after an index hospitalization and track metrics such as 30- and 90-day readmission, ongoing infection markers, health-related quality of life, and utilization of home health or outpatient surgical services. This research helps providers and payers identify interventions that reduce costly readmissions, optimize transition-of-care pathways, and target resources to high-risk subgroups to improve long-term outcomes and reduce total episode costs.

    Related Codes

    734-PELVIC-EVISCERATION-RADICAL-HYSTERECTOMY-AND-RADICAL-VULVECTOMY-WITH-CC-MCC

    Pelvic Evisceration, Radical Hysterectomy and Radical Vulvectomy with CC/MCC: Inpatient Reimbursement Overview

    735-PELVIC-EVISCERATION-RADICAL-HYSTERECTOMY-AND-RADICAL-VULVECTOMY-WITHOUT-CC-MCC

    Pelvic Evisceration, Radical Hysterectomy and Radical Vulvectomy: Inpatient Reimbursement Overview

    736-UTERINE-AND-ADNEXA-PROCEDURES-FOR-OVARIAN-OR-ADNEXAL-MALIGNANCY-WITH-MCC

    Uterine and Adnexa Procedures for Ovarian or Adnexal Malignancy with MCC: Inpatient Reimbursement Overview

    737-UTERINE-AND-ADNEXA-PROCEDURES-FOR-OVARIAN-OR-ADNEXAL-MALIGNANCY-WITH-CC

    Uterine and Adnexa Procedures for Ovarian or Adnexal Malignancy with CC: Inpatient Reimbursement Overview

    738-UTERINE-AND-ADNEXA-PROCEDURES-FOR-OVARIAN-OR-ADNEXAL-MALIGNANCY-WITHOUT-CC-MCC

    Uterine and Adnexa Procedures for Ovarian or Adnexal Malignancy without CC/MCC: Inpatient Reimbursement Overview

    739-UTERINE-AND-ADNEXA-PROCEDURES-FOR-NON-OVARIAN-AND-NON-ADNEXAL-MALIGNANCY-WITH-MCC

    Uterine and Adnexa Procedures for Non-Ovarian and Non-Adnexal Malignancy with MCC: Inpatient Reimbursement Overview

    740-UTERINE-AND-ADNEXA-PROCEDURES-FOR-NON-OVARIAN-AND-NON-ADNEXAL-MALIGNANCY-WITH-CC

    Uterine and Adnexa Procedures for Non-Ovarian and Non-Adnexal Malignancy with CC: Inpatient Reimbursement Overview

    741-UTERINE-AND-ADNEXA-PROCEDURES-FOR-NON-OVARIAN-AND-NON-ADNEXAL-MALIGNANCY-WITHOUT-CC-MCC

    Uterine and Adnexa Procedures for Non-Ovarian and Non-Adnexal Malignancy without CC/MCC: Inpatient Reimbursement Overview

    742-UTERINE-AND-ADNEXA-PROCEDURES-FOR-NON-MALIGNANCY-WITH-CC-MCC

    Uterine and Adnexa Procedures for Non-Malignancy with CC/MCC: Inpatient Reimbursement Overview

    743-UTERINE-AND-ADNEXA-PROCEDURES-FOR-NON-MALIGNANCY-WITHOUT-CC-MCC

    Uterine and Adnexa Procedures for Non-Malignancy without CC/MCC: Inpatient Reimbursement Overview

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    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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