ICD-10-PCS Code For Circulatory: Procedure Code Group Overview

The International Classification of Diseases, Tenth Revision, Procedure Coding System (ICD-10-PCS) code group 6A55 includes procedures performed to separate, remove, or collect blood products in the circulatory system. These ICD-10-PCS codes are used for inpatient documentation when extracorporeal apheresis therapies are performed to treat disease, manage blood component levels, or collect components for transfusion or donation. Accurate coding within the ICD-10-PCS 6A55 group is essential for proper inpatient reimbursement, as it captures the specific extracorporeal therapy performed and supports clinical documentation accuracy.

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Circulatory Pheresis Procedure Overview

Procedures in this group involve extracorporeal separation of blood products performed on the circulatory system to remove, exchange, or collect specific blood components. These operations target the physiological systems of the circulatory system and use apheresis techniques to separate plasma, platelets, leukocytes, or other elements from whole blood. Accurate ICD-10-PCS coding of these procedures ensures inpatient records reflect the specific extracorporeal therapy provided and supports correct case mix assignment and reimbursement.

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
6	Section	Extracorporeal or Systemic Therapies
A	Body System	Physiological Systems
5	Operation	Pheresis
5	Body Part	Circulatory

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ICD-10-PCS Code For Circulatory: Procedure Code Group Overview

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Circulatory Pheresis Procedure Overview

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
6	Section	Extracorporeal or Systemic Therapies
A	Body System	Physiological Systems
5	Operation	Pheresis
5	Body Part	Circulatory

When to Use

Use codes from this group when an inpatient receives extracorporeal pheresis directed at the circulatory system to remove, exchange, or collect blood components. Select the code that matches the specific type of component separated and the clinical intent of the apheresis procedure.

ICD-10-PCS Codes

12 rows

ICD-10-PCS Code	Description
6A550Z0	Pheresis of Erythrocytes, Single
6A550Z1	Pheresis of Leukocytes, Single
6A550Z2	Pheresis of Platelets, Single
6A550Z3	Pheresis of Plasma, Single
6A550ZT	Pheresis of Cord Blood Stem Cells, Single
6A550ZV	Pheresis of Hematopoietic Stem Cells, Single
6A551Z0	Pheresis of Erythrocytes, Multiple
6A551Z1	Pheresis of Leukocytes, Multiple
6A551Z2	Pheresis of Platelets, Multiple
6A551Z3	Pheresis of Plasma, Multiple

Showing 1–10 of 12

Typical Clinical Scenarios

An elderly patient with symptomatic hyperviscosity from Waldenström macroglobulinemia is admitted for acute worsening confusion and visual changes caused by very high circulating IgM levels. Inpatient plasmapheresis is performed via extracorporeal separation to rapidly remove plasma proteins and decrease viscosity while stabilizing neurologic status. Typical codes: 6A550Z3, 6A551Z3
A young adult donor undergoing a planned inpatient collection of hematopoietic stem cells for an allogeneic transplant after mobilization and apheresis; the admission is for scheduled collection and monitoring of citrate-related complications. Extracorporeal pheresis targeting hematopoietic stem cells is used to collect the transplanted cellular product for later infusion. Typical codes: 6A550ZV, 6A551ZV
A pediatric patient with refractory immune thrombocytopenia presents after failure of medical therapy and recurrent severe bleeding; inpatient therapeutic platelet apheresis is performed to rapidly increase circulating platelet counts while additional treatments are escalated. The procedure uses extracorporeal separation to remove or collect platelets as a short-term measure to control hemorrhage. Typical codes: 6A550Z2, 6A551Z2

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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When to Use

ICD-10-PCS Codes

12 rows

ICD-10-PCS Code	Description
6A550Z0	Pheresis of Erythrocytes, Single
6A550Z1	Pheresis of Leukocytes, Single
6A550Z2	Pheresis of Platelets, Single
6A550Z3	Pheresis of Plasma, Single
6A550ZT	Pheresis of Cord Blood Stem Cells, Single
6A550ZV	Pheresis of Hematopoietic Stem Cells, Single
6A551Z0	Pheresis of Erythrocytes, Multiple
6A551Z1	Pheresis of Leukocytes, Multiple
6A551Z2	Pheresis of Platelets, Multiple
6A551Z3	Pheresis of Plasma, Multiple

Showing 1–10 of 12

Typical Clinical Scenarios

An elderly patient with symptomatic hyperviscosity from Waldenström macroglobulinemia is admitted for acute worsening confusion and visual changes caused by very high circulating IgM levels. Inpatient plasmapheresis is performed via extracorporeal separation to rapidly remove plasma proteins and decrease viscosity while stabilizing neurologic status. Typical codes: 6A550Z3, 6A551Z3
A young adult donor undergoing a planned inpatient collection of hematopoietic stem cells for an allogeneic transplant after mobilization and apheresis; the admission is for scheduled collection and monitoring of citrate-related complications. Extracorporeal pheresis targeting hematopoietic stem cells is used to collect the transplanted cellular product for later infusion. Typical codes: 6A550ZV, 6A551ZV
A pediatric patient with refractory immune thrombocytopenia presents after failure of medical therapy and recurrent severe bleeding; inpatient therapeutic platelet apheresis is performed to rapidly increase circulating platelet counts while additional treatments are escalated. The procedure uses extracorporeal separation to remove or collect platelets as a short-term measure to control hemorrhage. Typical codes: 6A550Z2, 6A551Z2

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

ICD-10-PCS Code For Circulatory: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Circulatory: Procedure Code Group Overview policy alerts

Circulatory Pheresis Procedure Overview

Code Attributes

ICD-10-PCS Code For Circulatory: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Circulatory: Procedure Code Group Overview policy alerts

Circulatory Pheresis Procedure Overview

Code Attributes

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Which procedures are included in ICD-10-PCS code group 6A55?

What is the Section, Body System, and Operation attributes for 6A55 codes?

How do the single versus multiple distinctions appear in the 6A55 code set?

Why is accurate coding within the 6A55 group important for inpatient records?

What specific ICD-10-PCS code would represent pheresis of plasma as a single procedure?

References

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Which procedures are included in ICD-10-PCS code group 6A55?

What is the Section, Body System, and Operation attributes for 6A55 codes?

How do the single versus multiple distinctions appear in the 6A55 code set?

Why is accurate coding within the 6A55 group important for inpatient records?

What specific ICD-10-PCS code would represent pheresis of plasma as a single procedure?

References