Drug prior authorization requirements
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Explains why certain drugs require prior authorization and describes who performs reviews, how drugs are listed, and where to obtain criteria. Applies to WPS Health Insurance members and providers using WPS-managed or partner pharmacy/medical benefit managers.
No material clinical or coverage changes in this revision.
Coverage criteria and general policy stance
General coverage stance
Covered when meeting medical necessity and prior authorization requirements
If third-party reviewers (ESI, CCUM, eviCore) cannot complete review, submit to WPS; if the group's PBM differs from ESI, submit to that PBM.
General PA requirement
Coverage stance for listed drugs
Delegated reviewer or WPS routing required; follow per‑drug reviewer assignment.
General PA coverage conditions
Covered when routed through appropriate reviewer and PA is obtained
Providers must submit to the reviewer noted for the drug (ESI, CCUM, eviCore) or to WPS if the external reviewer cannot complete the review.
Reviewer contact numbers and submission instructions are provided in the document (Description, 4).
General PA requirement
Covered only with prior authorization
See per‑drug entries for HCPCS/J‑codes, benefit type (P/M), and reviewer assignment.
General coverage stance for listed drugs
Covered only with prior authorization when submitted to the assigned reviewer or WPS
Submit to the assigned reviewer (ESI, CCUM, eviCore) or to WPS if the reviewer cannot complete the review; if using a different PBM, submit to that PBM.
Prior Authorization Requirement (general)
Drugs on this list are subject to prior authorization review
Reviewer contact numbers and per‑drug HCPCS/benefit type are provided in the document.
General PA Requirement
Covered when prior authorization is obtained
This section provides administrative routing and coding; clinical medical necessity criteria are handled by the assigned reviewer and are not detailed in these chunks.
Prior authorization requirement (list-based)
Covered when prior authorization is obtained for listed drugs
Applies to every drug entry in this part of the list; follow per‑drug reviewer and code fields when submitting PA.
Services that are considered experimental, investigational, or unproven under applicable clinical guidelines are not covered. Coverage for drugs and related services is subject to medical necessity review and will be denied when the requested use is judged to fall into these unproven categories.
No specific exclusion conditions are identified in this section of the document. The listing is administrative and instructs that all drugs on the published list require prior authorization; routing and reviewer assignment are provided rather than discrete clinical exclusions.
This excerpt does not present any explicit exclusions. Entries list products with benefit type, billing codes, reviewer assignment, and comments, and indicate that prior authorization is required for each listed drug.
No drug-specific exclusions are provided in these chunks. The document emphasizes that every drug shown requires prior authorization, with per-drug reviewer routing and HCPCS/J-codes supplied for billing and submission.
This portion of the material is administrative: it assigns the prior authorization requirement and the reviewer for each listed product. It does not contain clinical coverage criteria or explicit exclusions; providers should follow the PA routing and documentation fields included with each entry when submitting requests.
No clinical coverage exclusions are specified in these chunks. The content is an administrative listing that indicates benefit type, HCPCS code, and the delegated reviewer; all listed drugs require prior authorization per the document instructions.
There are no drugs identified as exempt in this excerpt. For listed products, the instruction is to submit prior authorization requests to the designated reviewer (ESI, CCUM, eviCore) or to WPS if the reviewer cannot complete the review.
This section contains a list of products subject to prior authorization and routing instructions; it does not include explicit clinical exclusions. Providers must submit PA to the assigned reviewer (e.g., eviCore for oncology items) or to WPS for escalation.
No explicit exclusions are provided in these chunks. The listing focuses on benefit type, HCPCS/administrative codes, reviewer assignment, and reviewer contact information for prior authorization submission.
No exclusion conditions are specified here. The document reiterates that all drugs on the list require prior authorization and provides reviewer routing and HCPCS codes for each entry.
This excerpt does not list exclusions. It shows biosimilar entries and confirms that each product on the PA list requires authorization and the reviewer assignment; follow the listed reviewer instructions when submitting requests.
Requests for uses judged to be experimental, investigational, or unproven may be determined to be not medically necessary and therefore denied. Coverage determinations remain subject to the medical necessity standards of the member’s policy.
These chunks do not specify particular conditions that would be labeled not medically necessary. The content is administrative and centers on assigning prior authorization and reviewer routing for listed drugs.
No explicit not medically necessary criteria are provided in this portion of the document; the entries are administrative and indicate PA requirement and reviewer routing rather than clinical denial rules.
Not applicable in this extract — these chunks do not present specific not medically necessary statements. The listing is focused on PA requirements and reviewer assignments.
No explicit not medically necessary conditions are stated in this part of the document. Providers should follow the PA processes and reviewer routing shown for each drug to obtain a coverage determination.
These chunks do not include discrete not medically necessary rules. The document reiterates administrative PA requirements and reviewer submission instructions for listed drugs.
Billing codes and HCPCS/other code listings
| J3490 | CMS miscellaneous drug code listed in the drug list entries (example: topical 5-fluorouracil, adapalene/benzoyl peroxide) |
| J9190 | 5-fluorouracil injection (example from list) |
| J0129 | Abatacept (example listed) |
| J8999 | Unclassified antineoplastic drug (listed for multiple oral oncology agents) |
| J9354 | Ado-trastuzumab emtansine (KADCYLA) (listed) |
| J0172 | Aducanumab (ADUHELM) (listed) |
| J7352 | Afamelanotide acetate (SCENESSE) (listed) |
| Q2057 | HCPCS for afamitresgene autoleucel (TECELRA) (listed) |
| Q5149 | Aflibercept-abzv biosimilar (ENZEEVU) (listed) |
| J0180 | Agalsidase beta (FABRAZYME) (listed) |
| Q5147 | HCPCS code for aflibercept-ayyh (biosimilar) |
| Q5170 | HCPCS code for aflibercept-boav (biosimilar) |
| Q5155 | HCPCS code for aflibercept-jbvf (biosimilar) |
| Q5150 | HCPCS code for aflibercept-mrbb (biosimilar) |
| Q5153 | HCPCS code for aflibercept-yszy (biosimilar) |
| J0180 | HCPCS code for agalsidase beta |
| J3490 | HCPCS code used for albiglutide, albuterol inhaler, many others |
| J9015 | HCPCS code for aldesleukin |
| J8999 | HCPCS code used for alectinib - oral and others |
| J0202 | HCPCS code for alemtuzumab |
| J7198 | listed with apalutamide |
| J8999 | listed with apalutamide |
| J9022 | atezolizumab |
| J2782 | avacincaptad pegol |
| J9053 | belantamab mafodotin-blmf |
| J0485 | belatacept |
| Q5129 | bevacizumab-adcd |
| Q5107 | bevacizumab-awwb |
| J0584 | burosumab-twza (example J-code listed) |
| J0598 | c1 esterase inhibitor (example J-code listed) |
| J0599 | HAEGARDA (example J-code listed) |
| J0596 | RUCONEST (example J-code listed) |
| J9043 | cabazitaxel (example J-code listed) |
| J9064 | CABAZITAXEL (alternate J-code listed) |
| J0739 | cabotegravir (example J-code listed) |
| J9118 | asparlas / related oncology J-code |
| J8499 | Miscellaneous drug J-code (appears repeatedly for pharmacy benefit items) |
| J8522 | capecitabine - oral |
| C9098 | CARVYKTI CAR-T therapy code |
| Q2056 | CARVYKTI alternate code |
| J0567 | cerliponase alfa |
| J0889 | daprodustat (example code listed) |
| J9145 | daratumumab (example code listed) |
| J0881 | darbepoetin alfa (example code listed) |
| J0882 | darbepoetin alfa (alternate code listed) |
| J9150 | daunorubicin (example code listed) |
| J9153 | daunorubicin/cytarabine liposome (VYXEOS LIPOSOME) |
| J0589 | daxibotulinumtoxinA-lanm (example code listed) |
| J0894 | decitabine (example code listed) |
| J0893 | decitabine (Sun Pharma) (example code listed) |
| J8999 | multiple oral oncology or unspecified drug codes (used for several oral agents) |
| J8499 | Listed frequently as HCPCS placeholder code |
| J8999 | Listed as HCPCS placeholder code |
| J9177 | HCPCS code shown for enfortumab vedotin-ejfv |
| J1325 | HCPCS code shown for epoprostenol sodium |
| J0885 | HCPCS code shown for epoetin alfa |
| Q5105 | HCPCS code shown for epoetin alfa-epbx |
| J3032 | HCPCS code shown for eptinezumab-jjmr |
| J9178 | HCPCS code shown for epirubicin |
| J1305 | HCPCS code shown for evinacumab-dgnb |
| J3590 | HCPCS code shown for several products (e.g., evolocumab) |
| J8499 | Listed as HCPCS code for multiple pharmacy benefit drugs (placeholder misc drug code) |
| J3031 | HCPCS code listed for fremanezumab-vfrm |
| J9395 | HCPCS code listed for fulvestrant |
| J1595 | HCPCS code listed for glatiramer acetate (GLATOPA) |
| J1628 | HCPCS code listed for guselkumab |
| J1746 | HCPCS code listed for ibalizumab-uiy (TROGARZO) |
| C9081 | HCPCS code listed for idecabtagene vicleucel |
| Q2055 | HCPCS code listed for idecabtagene vicleucel |
| S0132 | HCPCS code listed for ganirelix acetate |
| J9201 | HCPCS code listed for gemcitabine |
| J1556 | HCPCS Code listed for BIVIGAM (immun glob g(igg)/gly/iga ov50) |
| J1569 | HCPCS Code listed for GAMMAGARD LIQUID (immun glob g(igg)/gly/iga ov50) |
| J1459 | HCPCS Code listed for PRIVIGEN (immun glob g(igg)/pro/iga 0-50) |
| J1559 | HCPCS Code listed for HIZENTRA (immun glob g(igg)/pro/iga 0-50) |
| J1551 | HCPCS Code listed for CUTAQUIG (immun glob g(igg)-hipp/maltose) |
| J1576 | HCPCS Code(s) listed for PANZYGA (immun glob g(igg)-ifas/glycine) - also J1599 referenced |
| J1566 | HCPCS Code listed for GAMMAGARD S-D |
| J1561 | HCPCS Code listed for GAMUNEX-C / GAMMAKED |
| J1568 | HCPCS Code listed for OCTAGAM |
| J1577 | HCPCS Code listed for QIVIGY XEMBIFY (immune globulin gamma(igg)klhw) |
| J1558 | HCPCS Code listed for XEMBIFY (immune globulin gamma(igg)klhw) |
| J1554 | HCPCS Code listed for ASCENIV (immune globulin gamma(igg)slra) |
| J0588 | HCPCS Code listed for incobotulinumtoxin A (XEOMIN) |
| J1823 | HCPCS Code listed for inebilizumab-cdon (UPLIZNA) |
| J1745 | HCPCS Code listed for infliximab (REMICADE) |
| Q5104 | HCPCS/secondary code listed for infliximab-abda (RENFLEXIS) |
| Q5121 | HCPCS/secondary code listed for infliximab-axxq (AVSOLA) |
| J1748 | HCPCS Code listed for infliximab-dyyb (INFLECTRA, ZYMFENTRA) |
| C9399 | HCPCS code referenced for inotersen sodium (TEGSEDI) |
| J9229 | HCPCS Code listed for inotuzumab ozogamicin (BESPONSA) |
| J3490 | Generic HCPCS/unspecified drug code used for multiple pharmacy drugs (e.g., insulin entries, lifileucel, others) |
| J8499 | HCPCS/general oral/injectable unspecified code used for many oral specialty drugs |
| J8999 | HCPCS unspecified code used for certain specialty or oral oncology agents |
| J1961 | HCPCS Code listed for lenacapavir (SUNLENCA) |
| J1954 | listed in table for leuprolide acetate/norethindrone (example) |
| J1950 | listed in table for leuprolide-related entries (example) |
| J9359 | loncastuximab tesirine-lpyl (ZYNLONTA) J-code |
| J3490 | Miscellaneous drug code (used for multiple listed drugs) |
| J8499 | Unclassified biologics/drugs (used for multiple listed drugs) |
| J9223 | lurbinectedin (ZEPZELCA) J-code |
| J9350 | mosunetuzumab-axgb (LUNSUMIO) J-code |
| J9246 | melphalan flufenamide / melphalan related J-code |
| J9248 | melphalan HCL inj J-code |
| J0887 | methoxy peg-epoetin beta J-code |
| J9348 | naxitamab-gqgk |
| J9295 | necitumumab |
| J9261 | nelarabine |
| J2350 | ocrelizumab |
| J2406 | oritavancin diphosphate |
| J9263 | oxaliplatin |
| J2507 | pegloticase |
| J9226 | example not present (no inference) |
| J2508 | HCPCS/J-code listed for pegunigalsidase alfa / pegvaliase-pqpz |
| J3490 | HCPCS/J-code listed for multiple drugs (pegunigalsidase alfa, pegvisomant, etc.) |
| J2778 | HCPCS/J-code listed for ranibizumab (LUCENTIS) |
| Q5128 | HCPCS code listed for ranibizumab-eqrn (CIMERLI) |
| J8499 | Miscellaneous HCPCS/J-code (as listed for many pharmacy products) |
| J2820 | Sargramostim HCPCS (per document) |
| J3590 | Sarilumab / similar J-code noted |
| J2840 | Sebelipase alfa HCPCS |
| C9166 | Secukinumab HCPCS |
| J3247 | Secukinumab (IV) HCPCS |
| J8999 | Oral oncology/other misc J-code used for many oral agents |
| J9331 | Sirolimus protein-bound particles HCPCS |
| J2941 | Somatropin HCPCS |
| J1447 | tbo-filgrastim HCPCS |
| J8700 | temozolomide - oral |
| J9328 | temozolomide - inj |
| J9330 | temsirolimus |
| J8499 | multiple drugs listed as J8499 (various pharmacy-coded drugs) |
| J9381 | teplizumab-mzwv |
| J8999 | multiple oral oncology/other agents |
| J3241 | teprotumumab-trbw |
| J3110 | teriparatide |
| J3490 | various topical/ophthalmic/pharmacy items |
| J3262 | tocilizumab |
| J3380 | vedolizumab HCPCS code (as listed) |
| J3385 | velaglucerase alfa HCPCS code (as listed) |
| J0217 | velmanase alfa HCPCS code (as listed) |
| J8499 | multiple oral/other drugs HCPCS code placeholder (as listed) |
| J8999 | multiple oral oncology/other drugs HCPCS code placeholder (as listed) |
| J3396 | verteporfin HCPCS code (as listed) |
| J3397 | vestronidase alfa-vjbk HCPCS code (as listed) |
| J1427 | viltolarsen HCPCS code (as listed) |
| J0225 | vutrisiran HCPCS code (as listed) |
| J7179 | von willebrand factor HCPCS code (as listed) |
What providers must do: submission, documentation, and denial risk
Prior authorization required for all listed drugs
All drugs listed require prior authorization before coverage will be approved. If ESI, CCUM, or eviCore cannot complete the review, submit the request to WPS for evaluation; if the group's PBM differs from ESI, submit to that PBM as instructed.
- PLEASE NOTE: All drugs on this list require a PA.
- If ESI, CCUM, or eviCore cannot complete the review, submit to WPS for evaluation.
- If using a PBM other than ESI through WPS, submit to the other PBM.
Network-specific PA submission rules (AETNA/Auxiant groups)
For WPS Powered by Auxiant groups using the AETNA Network, pharmacy benefit drugs require prior authorization through Express Scripts, eviCore, or WPS as indicated; medical benefit drugs do not require PA but a medical necessity review is recommended and notes should be faxed to American Health Holdings (AHH) as instructed.
- Pharmacy Benefit (P): PA required via ESI, eviCore, or WPS as indicated.
- Medical Benefit (M): PA not required; perform medical necessity review and fax notes to AHH at 608-273-4554.
Submit PA to designated PBM/reviewer
Submit prior authorization requests to the PBM or reviewer shown for each drug; if the PBM in use is not ESI, submit to that PBM per the listing.
- Follow the reviewer assignment in the per‑drug entry (ESI, CCUM, eviCore, or WPS).
- If the PBM differs from ESI, submit to the other PBM for pharmacy‑benefit drugs.
PA required; delegated reviewers perform reviews
All drugs on the published list require prior authorization; reviews are performed by delegated reviewers (ESI, CCUM, eviCore) as indicated for each drug or submitted to WPS if those reviewers cannot complete the review.
- Per‑drug entries list the designated reviewer; submit requests there first.
- If external reviewer cannot complete the review, submit to WPS for evaluation.
Routing: use indicated PBM/reviewer or escalate to WPS
If you use a PBM other than ESI, submit the PA to that PBM for drugs they review; if ESI, CCUM, or eviCore cannot complete the review, submit the request to WPS for evaluation.
- Submit to the PBM/reviewer indicated in the per‑drug 'Reviewer' field.
- Fallback: submit to WPS when the external reviewer cannot complete the review.
PA required — include HCPCS/J‑codes and reviewer
Prior authorization is required for the listed drugs; many entries include HCPCS/J‑codes and identify the reviewer organization that will process the PA request.
- Include the HCPCS/J‑code shown in the per‑drug entry with your PA submission.
- Use the reviewer assignment (ESI, CCUM, eviCore, or WPS) for routing.
Route PA to reviewer listed in column 4
Submit prior authorization requests following the reviewer assignment shown in column 4 of each drug entry (ESI, CCUM, eviCore, or WPS); that reviewer will handle the PA processing.
- Column 4 of each entry lists the designated reviewer and option number (e.g., ESI option 1, CCUM option 2, eviCore option 3).
- If the designated external reviewer cannot complete the review, submit to WPS.
PA required — include benefit type and HCPCS/admin codes
Prior authorization is required for each listed drug; per‑drug entries include the benefit type (P = Pharmacy, M = Medical) and HCPCS/administration codes which should be used for billing and submission.
- Reference the Benefit Type field (P or M) and HCPCS code in PA requests and claims.
- Use the reviewer specified in the per‑drug record (ESI, CCUM, eviCore, or WPS).
PA required — reviewer assigned with contact routing
All drugs listed require prior authorization; the document identifies the responsible reviewer (ESI, CCUM, eviCore, or WPS) and provides contact/routing instructions.
- Reviewer phone routing is provided in the Description, 4 field (ESI/CCUM/eviCore: 1‑800‑475‑1954; WPS: 1‑800‑333‑5003).
- Follow the per‑drug reviewer assignment to determine where to submit the PA.
Submit to indicated PBM/reviewer or escalate to WPS
Submit the PA to the PBM or reviewer indicated for the drug; if that reviewer cannot complete the review, submit to WPS for evaluation.
- Designated reviewers include ESI, CCUM, eviCore (option numbers shown) or WPS.
- Contact numbers are provided for vendor reviewers and WPS for escalation.
Each drug mapped to benefit type, HCPCS/J‑codes, and reviewer
Prior authorization is required for the listed drugs; the table associates each drug with benefit type, one or more HCPCS/J‑codes, and the designated reviewer responsible for the PA.
- Per‑drug entries show Alt Descriptions, Benefit Type, HCPCS Code, Reviewer, and Drug Comments.
- Providers should reference these fields when preparing PA submissions.
Submit PA to specified reviewer; fallback to WPS if needed
Submit prior authorization requests to the specified reviewer shown for each drug; if that reviewer cannot complete the review, submit to WPS for evaluation.
- If using a PBM other than ESI through WPS, submit to that PBM as instructed.
- Fallback to WPS when delegated reviewers cannot complete the review.
Route PA to listed reviewer using provided contact avenues
All drugs require prior authorization and submissions should be routed to the reviewer listed (ESI, CCUM, eviCore or WPS) based on the per‑drug 'Reviewer' field; use vendor contact avenues provided.
- Reviewer assignments determine routing; eviCore commonly handles oncology agents.
- Contact numbers and submission channels are provided in the per‑drug entries.
PA required — HCPCS codes and reviewer assignment included
Prior authorization is required for all drugs listed; each entry provides HCPCS/HCPCS‑like codes and assigns the reviewer (ESI, CCUM, eviCore, or WPS) to process the PA.
- Include the HCPCS/HCPCS‑like code from the per‑drug entry in PA and billing documentation.
- Submit to the reviewer assigned in the drug entry.
Submit PA to designated reviewer or PBM; escalate to WPS if needed
Submit the PA to the reviewer/PBM indicated for the drug (ESI, CCUM, eviCore); if they cannot complete the review, submit to WPS. If your group uses a PBM other than ESI through WPS, submit to that PBM.
- Designated reviewers and PBM routing are shown for each drug entry.
- WPS serves as the escalation path when delegated reviewers cannot complete review.
Escalate PA to WPS when external reviewer cannot complete review
If an external reviewer (ESI, CCUM, eviCore) cannot complete the review, submit the prior authorization request to WPS for evaluation; providers should follow the submission instructions for the designated reviewer first.
- Submit to the per‑drug reviewer initially; escalate to WPS when review cannot be completed externally.
- WPS contact number is provided for escalation.
Where to obtain PA and step‑therapy criteria
Step therapy and prior authorization criteria for drugs reviewed by Express Scripts or Care Continuum are available by calling 1-800-475-1954; eviCore criteria are available at evicore.com and gene therapy coverage should be confirmed with WPS Customer Service.
- Express Scripts / Care Continuum PA/step therapy: call 1-800-475-1954.
- eviCore clinical guidelines: https://www.evicore.com/provider/clinical-guidelines (search for 'WPS Health Insurance').
- Confirm Gene Therapy coverage with WPS Customer Service (member card number).
Step therapy not specified in this section
Per‑drug entries generally do not specify step therapy algorithms in this section; many entries include reviewer routing or 'see comments' rather than explicit step therapy steps.
- Some entries show 'see comments' or reviewer‑specific notes that may indicate additional utilization management handled by the reviewer.
- No explicit step therapy sequences or required prior failures are provided in these chunks.
No explicit step therapy rules in per‑drug listings
This section does not include explicit step therapy rules; per‑drug reviewer routing and comments are provided instead and may indicate reviewer‑specific requirements.
- Entries with 'see comments' may reflect additional utilization management by the assigned reviewer.
- Providers should consult the reviewer or the contact listed for specific PA/step therapy criteria.
Follow reviewer comments for additional requirements
Some per‑drug entries include 'see comments' which indicates that additional reviewer‑specific or drug‑specific requirements may apply; providers should follow reviewer guidance for those items.
- When 'see comments' appears, consult the designated reviewer (ESI/CCUM/eviCore) for any additional submission requirements.
- Reviewer may require supporting documentation or different routing depending on drug specialty.
Documentation used in PA reviews — supply medical records and references
Medical records describing the patient's condition and prior treatments, FDA labeling, peer‑reviewed literature, and evidence‑based guidelines are used during PA review and should be made available to reviewers.
- Provide medical records and prior treatment history with PA requests when relevant.
- Reviewers will reference FDA labeling and clinical literature in coverage determinations.
Where to submit prior authorization requests
Submit PA requests to the listed reviewer (ESI, CCUM, eviCore) shown for each drug; if the third‑party reviewer cannot complete the review, submit to WPS using the contact information provided.
- Reviewer contact avenues and option numbers are provided in Description, 4 of each entry.
- WPS contact provided for escalation when vendor reviewers cannot complete review.
Include HCPCS/billing code and benefit type on PA submissions
Include the per‑drug HCPCS/ billing code and benefit type (P = Pharmacy, M = Medical) when submitting PA requests so the reviewer can correctly route and process the request.
- Description fields: 1 = Alt Descriptions; 2 = Benefit Type; 3 = HCPCS Code; 4 = Reviewer; 5 = Drug Comments.
- Providers should supply the HCPCS/J‑code and benefit type from the per‑drug entry on the PA request.
Use listed HCPCS/J‑codes and reviewer contacts for submissions
Reference the HCPCS/J‑codes and benefit type listed for each drug when preparing claims or PA submissions and use the reviewer contact numbers if clarification or additional information is needed.
- Per‑drug entries include HCPCS/HCPCS‑like codes to be used for billing and routing.
- Use the reviewer phone numbers shown in the document for submission or questions.
Provide per‑drug description fields with PA requests
Each drug entry contains fields (alternate description, benefit type, HCPCS code, reviewer, drug comments); providers should supply this information with PA requests to ensure accurate routing and review.
- Description, 1 = Alt Descriptions; 2 = Benefit Type; 3 = HCPCS Code; 4 = Reviewer; 5 = Drug Comments.
- Providing all fields reduces delays and supports reviewer evaluation.
Submit PA to the designated reviewer using provided contacts
The table provides HCPCS/administrative codes and the designated reviewer to contact (ESI, CCUM, eviCore, or WPS) for PA processing; contact numbers are listed for reviewers and WPS for escalation.
- Submit to the designated reviewer indicated in the per‑drug entry.
- If the designated reviewer cannot complete review, use WPS contact for escalation.
Use benefit type and HCPCS codes for billing and routing
Per‑drug entries include benefit type and HCPCS codes that should be used for billing and reviewer routing; include the appropriate HCPCS/J‑code and benefit type when submitting the PA.
- Benefit Type: P = Pharmacy, M = Medical.
- Include the HCPCS/J‑code listed in Description, 3 on PA forms and claims.
Designated reviewer submission and escalation contacts
Submit PA requests to the designated reviewer (ESI, CCUM, or eviCore) shown for each drug; if those reviewers cannot complete the review, submit to WPS for evaluation. Contact numbers for ESI/eviCore (1‑800‑475‑1954) and WPS (1‑800‑333‑5003) are provided.
- ESI/eviCore phone: 1‑800‑475‑1954.
- WPS phone for escalation: 1‑800‑333‑5003.
Use reviewer routing and contact info from the table
Reviewer contact information and reviewer assignment are provided in the per‑drug entries; submit PA to the listed reviewer (ESI, CCUM, eviCore) or to WPS if external reviewers cannot complete the review.
- Reviewer assignments appear in Description, 4 for each drug entry.
- Use the provided phone numbers for submission or questions.
Required documentation elements for PA submission
Each drug entry includes alternate descriptions, benefit type (P = Pharmacy), HCPCS/billing code, reviewer assignment (ESI, CCUM, eviCore, or WPS) and drug comments; providers should submit PA requests to the assigned reviewer or to WPS if the reviewer cannot complete the review.
- Include alternate description and HCPCS code to ensure correct review routing.
- Follow reviewer assignment; escalate to WPS when necessary.
Reviewer routing and escalation contact information
Reviewer contact routing is provided: ESI, CCUM, and eviCore have phone numbers for submission and WPS is the escalation contact when external reviewers cannot complete review.
- Use vendor reviewer contact for initial submission; escalate to WPS if vendor cannot complete review.
- Reviewer contact numbers are included in the per‑drug entries.
Route PA to listed reviewer; use WPS if vendor cannot complete review
PA submissions should be routed to the listed reviewer per drug (ESI, CCUM, eviCore or WPS) using the provided contact numbers when a vendor cannot complete the review.
- Submit to the reviewer indicated in the per‑drug 'Reviewer' field.
- When the reviewer cannot complete the review, submit to WPS using the escalation contact.
Submit PA to designated reviewer/PBM with required codes
Providers must submit PA requests to the designated reviewer/PBM listed for each drug (ESI, CCUM, eviCore, or WPS) using the contact avenues noted; include the HCPCS/billing code and benefit type from the per‑drug entry.
- Designated reviewer is shown in each entry; use their contact channel for PA submission.
- Include HCPCS code and benefit type to avoid processing delays.
Reviewer contact numbers and submission routing for escalation
Reviewer contact numbers and reviewer assignment (ESI, CCUM, eviCore, or WPS) are provided for submission if external reviewers cannot complete the review; use these contacts for escalation.
- Contact numbers for reviewers and WPS are provided in the document.
- Escalate to WPS when delegated reviewers cannot complete review.
Denial risk for experimental/investigational services
Services deemed experimental, investigational, and/or unproven under clinical guidelines will not be covered and may be denied; ensure requested use aligns with accepted clinical guidance.
- Requests for indications considered experimental, investigational, or unproven may be determined not medically necessary and denied.
- Provide supporting clinical evidence when requesting coverage for non‑standard uses.
Denial risk if PA not obtained for listed drugs
Failure to submit a prior authorization for any drug on this list may result in denial or deferral of coverage because the policy states that all drugs on the list require a PA.
- PLEASE NOTE: All drugs on this list require a PA.
- Claims for listed drugs may be denied if PA is not obtained and submitted to the listed reviewer.
Initial therapy prior authorization requirements
Initial therapy PA requirement
General
No additional clinical entry criteria are provided in these chunks; reviewers will apply clinical/medical necessity standards during the PA review.
Step therapy and sequence information
| Note |
|---|
| Step therapy and PA criteria are available from the designated reviewers: for Express Scripts or Care Continuum call 1-800-475-1954; for eviCore see https://www.evicore.com/provider/clinical-guidelines (search 'WPS Health Insurance'). |
| Observation |
|---|
| No explicit step-therapy steps are listed in this section; entries provide benefit type and reviewer routing instead. |
| Comment |
|---|
| The document does not specify step therapy sequences; routing to ESI, CCUM, or eviCore for review may imply additional utilization management handled by those reviewers. |
| Summary |
|---|
| No required prior failures or explicit step sequencing are provided; the policy lists per-drug reviewer assignments (including 'see comments' where applicable) for clinical review. |
| Interpretation |
|---|
| Entries marked 'see comments' may indicate reviewer-specific or drug-specific utilization management steps are applied by the reviewer, but explicit step therapy algorithms are not present in the excerpt. |
| Requirement |
|---|
| Initial administrative requirement: submit prior authorization to the designated reviewer (ESI, CCUM, or eviCore) shown for each drug; if those reviewers cannot complete the review, submit to WPS for evaluation. |
| Note |
|---|
| No step therapy requirements are specified in these chunks; the list indicates PA is required and provides reviewer routing for each drug. |
| Observation |
|---|
| No explicit step therapy sequences are specified; reviewer assignment (ESI, CCUM, eviCore) and routing are the primary operational rules in these entries. |
| Finding |
|---|
| No explicit step therapy sequences or prior-failure requirements are listed; entries include reviewer routing and specialty flags (e.g., Oncology, MH/SUD) only. |
| Routing Options |
|---|
| Reviewer routing options are specified (ESI = option 1, CCUM = option 2, eviCore = option 3); the excerpt provides routing rather than explicit clinical step-therapy sequences. |
Site-of-care and benefit type guidance
Biosimilar entries and special coding
Field and term definitions
Background and rationale
Prior authorization is used to confirm the appropriate use of certain drugs and to determine whether a requested drug meets the medical necessity requirements of the member’s policy. It is an authorization step that must be completed before coverage will be approved for drugs on the list.
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