Formulary (List of Covered Drugs) Changes
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Lists upcoming and past changes to Independent Health commercial drug formularies and indicates affected drugs, change types, prior authorization, step therapy and alternatives; applies to Independent Health members across plans tracked in the document.
Stelara was removed from the formulary (changed to Non-Formulary) effective 7/1/2025.
Victoza was removed from the formulary (changed to Non-Formulary) effective 10/1/2025.
Multiple Revlimid (lenalidomide) tablet strengths (2.5, 5, 10, 15, 20, 25 mg) were removed from the formulary effective 10/1/2025.
Jynarque (tolvaptan) product presentations were removed from the formulary effective 1/1/2026.
Orladeyo (110 mg and 150 mg) was removed from the formulary effective 1/1/2026.
A large number of branded biologics and biosimilars were changed to Non-Formulary effective 1/1/2026 with listed alternatives.
Noxafil packet was removed from the formulary effective 1/1/2026.
Dayvigo 5 mg was removed from the formulary effective 1/1/2026.
Multiple drugs had tier assignments and PA requirements revised (e.g., Dayvigo 5mg moved from Tier 2 to Tier 3 with PA).
Several hepatitis C products had tier changes (many from Tier 3 to Tier 2) and formulary group reassignment.
Multiple specialty biologics and biosimilars (e.g., Abrilada, Cosentyx, Cimzia) had formulary tier/status/table information updated.
Numerous opioid and analgesic extended-release products had tier reassignment with effective dates in March 2026.
Certain CNS/sleep agents had tier changes and substitution mappings.
Several generic and contraceptive products had tier changes and formulary group updates.
Multiple branded and generic products moved from Tier 1 to Tier 3 and some were marked NF with effective date 3/1/2026 for specific items.
A set of products (Sancuso patch; Relistor formulations; Symproic; Xarelto 2.5mg) are scheduled to change to Non‑Formulary on 7/1/2026.
Numerous tier adjustments effective 9/1/2025 or 1/1/2026 for stimulant agents, dermatology agents, antifungals, and other drugs.
Multiple drugs have updated tier assignments and/or Drug Formulary impacts effective on various dates (mostly 1/1/2026, 3/1/2026, or 7/1/2026).
Coverage Criteria and Formulary Status
Products designated NF (Non‑Formulary) in the listings are excluded from coverage under the Independent Health formulary effective on the date shown for each entry. Examples in this document include a range of biologics, specialty agents and other branded products (e.g., Stelara effective 7/1/2025; multiple Revlimid strengths effective 10/1/2025; Jynarque and select Orladeyo presentations effective 1/1/2026; and multiple Humira and Abrilada presentations effective 1/1/2026), which are listed as NF and therefore will no longer be covered under the formulary after the listed effective date.
When a product is moved to NF, the document includes any specified alternatives or therapeutic substitutions where provided (for example, alternatives listed for Stelara include Yesintek, Selarsdi, adalimumab, Otezla, Skyrizi, Taltz, Rinvoq, Xeljanz or Xeljanz XR; Revlimid entries list generic lenalidomide; Jynarque entries reference tolvaptan (generic Jynarque)), and indicates the impacted Drug Formulary(s). Requests for coverage of NF products may be denied unless a medical exception is approved.
This document summarizes upcoming formulary updates including status changes (e.g., Non‑Formulary (NF) designations), tier reassignments, and administrative flags such as PA (prior authorization) and ST (step therapy). Entries list the affected product presentation, prior status, the change type and effective date, any indicated PA or ST requirement, and specified substitution or alternative agents where provided.
The listings cover a broad set of therapeutic classes—biologics and biosimilars, hepatitis C antivirals, CNS/sleep agents, opioid and neuropathic agents, contraceptives, and oral hypoglycemics—showing the new formulary placement (Tier or NF), whether PA or ST applies, and the effective date for each change. Where the entry provides alternatives, those mappings represent the formulary‑preferred or suggested substitutions that providers should consider when selecting therapy.
Providers should note and document the exact formulation and the effective date shown for each product when managing prescriptions and authorization requests: the presence of a PA flag requires submission and Independent Health approval for coverage, and products listed as NF after the effective date will not be covered except via an approved medical exception.
Provider Actions: Prior Authorization, Step Therapy, and Denials
Prior Authorization Required
Prior Authorization (PA) remains required for drugs listed with a 'PA' in the change listings. Providers must submit a prior authorization request (or medical exception request) to Independent Health for coverage of any drug flagged 'PA'. Do not assume PA is removed when a tier changes — review the specific drug entry.
- Affected examples: Cibinqo (all strengths) retain PA with the tier changes (see Tier Changes entries).
- Posaconazole (suspension and 100 mg tablet) are noted with PA after tier adjustments — PA is required. (See posaconazole entries.)
- Nitisinone (multiple strengths) entries include PA on new tiers — PA is required for these products.
PA Remains Required Where Listed
Prior authorization continues to apply where listed even when products change tiers or status. Several products moving tiers still require PA both before and after the change; providers must follow existing PA rules and submit required documentation.
- Many specialty and hepatitis C products (e.g., Epclusa, Sovaldi, Epclusa packs) show PA in both prior and new tier rows — submit PA per current criteria.
- Stelara and multiple Revlimid strengths were previously PA and are now designated NF; PA remains relevant for clinical exception requests.
- Cibinqo entries explicitly list PA on both Tier 2 and Tier 3 effective dates — ensure PA is included with any authorization request.
Prior Authorization Additions
New prior authorization assignments have been added for selected products. When a drug is newly assigned PA in the change listing, providers must obtain PA before the plan will cover the medication.
- Posaconazole suspension and posaconazole 100 mg tablets are newly listed with PA effective 1/1/2026 (moved from 9/1/2025 entries).
- Nitisinone formulations (2 mg, 5 mg, 10 mg, 20 mg) show PA assignments across impacted formularies and effective dates — follow PA rules.
- Examples of other products newly shown as NF may still require PA for medical exceptions (e.g., Stelara entries).
Non‑Formulary Triggers Denial
Non-Formulary (NF) designations will result in coverage denial under the formulary benefit unless a medical exception is approved. Providers should expect denied claims when the drug is designated NF as of the listed effective date unless an approved exception is on file.
- Drugs listed as 'NF' (for example: Stelara effective 7/1/2025; multiple Revlimid strengths effective 10/1/2025; many entries effective 1/1/2026) will no longer be covered under the formulary.
- If an alternative formulary drug is available, those alternatives are listed in the change entries — consider switching to the listed alternative prior to submitting an exception.
- For NF drugs, submit a medical exception request with supporting clinical documentation if coverage is medically necessary.
Step Therapy (ST) Applies
Step Therapy (ST) applies where indicated. When a drug is listed with 'ST' in the change details, providers must ensure step therapy requirements are met or submit documentation supporting an exception.
- Victoza is listed as ST prior to becoming NF — follow existing step therapy rules until the NF date (Victoza NF 10/1/2025).
- Sancuso transdermal patch is listed with ST prior to NF — ensure step requirements are met prior to 7/1/2026.
- If a product retains ST on the new tier, continue to follow step edits when prescribing and authorizing.
Preferred Alternatives / Substitution Mapping
Preferred alternatives and substitution options are listed for many changed drugs. When a non‑preferred or NF product has an indicated alternative, consider the listed alternatives prior to seeking an exception.
- Hepatitis C: Epclusa and Sovaldi entries list preferred alternatives such as Mavyret, sofosbuvir‑velpatasvir, or ledipasvir‑sofosbuvir — use preferred agents when clinically appropriate.
- Stelara and multiple biologics: Alternatives listed include adalimumab, Yesintek, Selarsdi, Rinvoq, Xeljanz, Skyrizi, Taltz, Otezla, Entyvio, Actemra, Kevzara, Zeposia, Orencia.
- For stimulant/ADHD products (e.g., lisdexamfetamine moving to Tier 3), alternatives include amphetamine‑dextroamphetamine, dextroamphetamine, dexmethylphenidate, and methylphenidate formulations.
Record Effective Date for Requests and Counseling
Document the effective dates and PA/ST status when submitting prior authorization or counseling members. Recordkeeping of the change effective date is essential because coverage, PA, ST, and NF statuses are date‑dependent.
- Examples: Cibinqo tier and PA changes are effective 1/1/2026 — ensure authorization requests reflect the correct effective date.
- Multiple posaconazole and nitisinone entries show effective date 1/1/2026 — verify member coverage and PA requirements on or after that date.
- Keep copies of submitted PA and clinical documentation tied to the date of service and the effective date of the formulary change.
Provider Operational Reminders
Action items and general provider obligations: verify formulary status and PA/ST requirements at the point of prescribing; consider listed alternatives before seeking exceptions; submit full clinical documentation with PA/exception requests; expect denials for NF drugs absent an approved exception.
- Check the member's specific drug formulary and benefit prior to dispensing or authorizing.
- For PA submissions include indication, prior therapies, clinical rationale, and relevant lab or diagnostic results.
- When an alternative is listed, first discuss substitution with the member and prescribing clinician to avoid unnecessary exceptions or denials.
Step Therapy Tables and Preferred Alternatives
| Product | Step Therapy (ST) Flag | Previous Step Requirement / Preferred Alternative |
|---|---|---|
| Victoza (liraglutide) | ||
| ST | ||
| Previously required step therapy; listed alternative = liraglutide |
| Listed Product | Mapped Preferred Alternative(s) | Effective Date / Tier note |
|---|---|---|
| Epclusa (various strengths / packs) | ||
| Mavyret; sofosbuvir-velpatasvir; ledipasvir-sofosbuvir | ||
| 1/1/2026; tier changes noted in source (various packs moved between Tier 2/3) |
| Affected stimulant / ADHD product | Preferred alternative(s) / implied step | Effective Date / Tier change |
|---|---|---|
| Lisdexamfetamine (capsules, chewables; multiple strengths) | ||
| amphetamine-dextroamphetamine (tablets & ER), dextroamphetamine (tablets & ER), dexmethylphenidate (tablets & ER), methylphenidate CD ER (capsule/tablet/chewable) | ||
| 9/1/2025; moved from Tier 1 to Tier 3 in many strengths |
| Product | Planned change (placement/tier) | Effective date (impact) |
|---|---|---|
| Erythromycin base 250 mg delayed‑release capsule | ||
| Current Tier = 1 → New Tier = 3 | ||
| Effective 7/1/2026 |
Biosimilar and Specialty Biologic Formulary Changes
Verify Abrilada (adalimumab biosimilar) SKU tier and PA status
Abrilada (adalimumab biosimilar) presentations are listed with Drug Formulary group assignments and some pack sizes retain Tier 2 with 'PA' while other Abrilada SKUs are shown as 'NF'; verify the specific Abrilada SKU's tier and PA status before prescribing or billing.
- Abrilada 40mg/0.8ml autoinjector and 20mg/0.4ml syringe entries show Tier 2 with PA for certain pack sizes and NF for others effective 1/1/2026.
- Confirm whether a given Abrilada SKU is NF or requires PA prior to dispensing or submitting a claim.
Definitions and Key Terms
Policy Revision History and Material Changes
Sancuso patch and multiple Relistor formulations (injections, prefilled syringes, tablets), Symproic 0.2 mg, and Xarelto 2.5 mg are scheduled to change to Non‑Formulary effective 7/1/2026.
Erythromycin base 250 mg delayed‑release capsule and doxylamine‑pyridoxine delayed‑release tablet are scheduled to move from Tier 1 to Tier 3 effective 7/1/2026.
Multiple opioid and analgesic extended‑release products (including tramadol ER biphasic 300 mg, various morphine ER strengths, codeine sulfate tablets, and related items) and select neuropathic agents (gabapentin once‑daily and Horizant formulations) were changed to Non‑Formulary effective 3/1/2026.
Gabapentin once‑daily 300 mg and 600 mg, Horizant 300/600 mg, and several butalbital‑acetaminophen formulations had tier increases and NF designation effective 3/1/2026.
Memantine 2 mg/mL oral solution and disulfiram 250 mg tablets have updated effective dates for tier assignments (document lists 3/1/2026 for these items).
A large set of branded biologics and biosimilars (including many adalimumab presentations, Abrilada, Cosentyx, Cimzia, Humira, and others) and numerous antiviral and specialty agents were changed to Non‑Formulary effective 1/1/2026 with listed alternatives.
Jynarque (tolvaptan) product presentations, Orladeyo (110 mg and 150 mg), Noxafil packet, Dayvigo 5 mg/10 mg, Quviviq, Wakix, Xyrem and multiple hepatitis C product packs/tablets (Epclusa, Harvoni, Sovaldi, Vosevi) were designated Non‑Formulary or had tier/PA revisions effective 1/1/2026.
Numerous tier adjustments effective 1/1/2026 affect stimulants, dermatology agents, antifungals (posaconazole), sapropterin, nitisinone, fenofibrate products, griseofulvin formulations and many others; some entries add or retain prior authorization requirements.
Victoza (liraglutide listed as alternative) and multiple Revlimid tablet strengths were removed from the formulary (changed to Non‑Formulary) effective 10/1/2025.
Stelara was removed from the formulary (changed to Non‑Formulary) effective 7/1/2025 with listed alternatives (Yesintek, Selarsdi, adalimumab, Otezla, Skyrizi, Taltz, Rinvoq, Xeljanz/XR).
Multiple stimulant and methylphenidate ER LA products and related formulations were reassigned between tiers (many moving to Tier 3) with effective date 9/1/2025.
Document current as of 2026-05-01 (source file date noted in brief).
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