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Attention Deficit Hyperactivity Disorder (ADHD) Stimulant Medications for Individual and Family Plans
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Cigna policy governing prior authorization and medical necessity criteria for stimulant medications indicated for ADHD and certain other conditions for Individual and Family Plans.
Added criteria for dextroamphetamine immediate-release tablets, methylphenidate ER tablets (45mg, 63mg, and 72mg), Relexxii, and Zenzedi.
Removed methylphenidate extended-release capsules (generic for Aptensio XR) from the list of alternatives in the preferred product criteria for several methylphenidate products and Relexxii.
Added Adzenys XR-ODT and generic amphetamine extended-release orally disintegrating tablets; updated preferred product and Vyvanse requirements.
Added multiple drugs including Adderall, Adderall XR, Aptensio XR, Azstarys, Concerta, Cotempla XR ODT, Desoxyn, Dexedrine and others to the policy.
Removed a phrase under 'Long-Term Combination Therapy with atomoxetine' for clarity.
Arynta (lisdexamfetamine oral solution) was added with same approval criteria as lisdexamfetamine capsules (Vyvanse).
Coverage Criteria for ADHD Stimulant Medications
Covered Indications
ADHD stimulant products are considered medically necessary when the individual meets ONE of the following indicated groups.
All approvals for listed indications are provided for up to 1 year when Preferred Product Criteria or other listed product-specific criteria are satisfied (see product-specific sections).
Product-specific Prior Authorization Criteria (partial)
Product-specific medical necessity criteria require meeting Preferred Product Criteria and, for certain branded/specialty products, documented prior trials of specified alternatives or an inability to tolerate/ingest alternatives.
Applies per age-specific rules where noted in product tables.
Prescriber attestation required for prior trials and outcomes.
Product-specific tables delineate which prior trials are required and whether prior generic/bioequivalent products count toward the trial.
Adzenys XR-ODT (amphetamine ER ODT) — medical necessity
Considered medically necessary when ONE of the following is met
Prescriber attestation required for prior trials and outcomes.
Aptensio XR (methylphenidate ER capsules) — medical necessity (excerpt)
Product-specific criteria follow the same two‑pathway structure
Lisdexamfetamine oral solution / Arynta (excerpted structure)
Follows same swallowing‑impaired OR stepped‑trial approach
Concerta (methylphenidate ER tablets) — medical necessity (excerpt)
Two main pathways with additional bioequivalent generic exception language
Bioequivalent generic exception is explicitly required for Concerta to be considered medically necessary when applicable.
Cotempla XR ODT and methylphenidate transdermal system (patch) — medical necessity (excerpt)
Same two‑pathway approach for specialty formulations
Dyanavel XR / Dyanavel XR ODT / Dyanavel XR chewable — medical necessity (excerpt)
Products with chewable/ODT/aqueous formulations follow swallowing‑impaired or stepped‑trial logic
Prescriber attestation required.
Dyanavel XR (and ODT) — Initial and continuing therapy
Dyanavel XR — coverage when the patient meets the following structured criteria
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Evekeo (IR) and Evekeo ODT
Evekeo and Evekeo ODT — coverage when the patient meets the following structured criteria
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Focalin (IR) and Focalin XR (ER)
Focalin and Focalin XR — coverage when the patient meets the following structured criteria
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Lisdexamfetamine chewable
Lisdexamfetamine dimesylate chewable tablets — coverage when the patient meets the following structured criteria
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Methylphenidate formulations and Methylin
Methylphenidate products (ER capsules, immediate‑release solution, Methylin) — coverage when patient meets the following structured criteria
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Prior-trial coverage criteria
Coverage requires documented prior trials and differs by age group and whether therapy is initial or continuation.
Previous history of dexmethylphenidate or methylphenidate use counts toward the trial.
Alternative sequences for patients currently receiving therapy require trials of amphetamine IR/ER and dexmethylphenidate or methylphenidate IR products as detailed in policy.
Prescriber attestation that prior trials resulted in inadequate efficacy or significant intolerance is required; previous history counts toward trials.
Reimbursement is not allowed for services billed for conditions or diagnoses that are not covered under this Coverage Policy. Claims must be submitted with the most appropriate covered diagnosis and procedure codes as of the date of service; claims submitted without covered code(s) under this policy will be denied as not covered. Coverage determinations are made in the context of the applicable benefit plan document, relevant laws/regulations, and documentation of medical necessity.
Concerta (methylphenidate ER tablets) may only be considered medically necessary when the prescriber documents that the patient has tried the bioequivalent generic methylphenidate ER tablet and is unable to take it because of a formulation difference in inactive ingredient(s) (for example, dyes, fillers, preservatives) that, per the prescriber, would cause a significant allergy or serious adverse reaction. Absent that documented inability to tolerate the bioequivalent generic, the Concerta-specific exception is not met.
Policy criteria emphasize two pathways for coverage — a swallowing‑impaired/formulation exception (ODT/chewable/liquid when the patient cannot swallow solids or cannot ingest the dose using sprinkle/openable products) OR an age‑stratified stepped‑therapy/prior‑trial pathway requiring documented inadequate efficacy or significant intolerance to specified alternative stimulant products. There are no broad universal exclusions for stimulant products; approval depends on meeting the product‑specific trials or formulation exceptions detailed for each drug.
Use of ADHD stimulant products for indications not listed in the policy (for example, fatigue associated with multiple sclerosis, neuroenhancement, and most weight‑loss indications) is addressed under 'Conditions Not Covered' and is considered not medically necessary.
Claims for services that are not accompanied by covered diagnosis or procedure code(s) under this Coverage Policy will be denied as not covered. Providers must submit the most appropriate codes current as of the effective date and include documentation supporting the medical‑necessity criteria specified in the policy.
Implicit denial scenarios include situations where required prior trials are not documented, age‑based criteria are not met, or product‑specific formulation exceptions (e.g., inability to take a bioequivalent generic) are not supported by the prescriber. Requests that do not meet either the swallowing‑impaired pathway or the stepped‑therapy/prior‑trial requirements for the specific product may be denied.
Long‑term combination therapy of CNS stimulants with atomoxetine (Strattera) for more than 2 months is considered not medically necessary. Short‑term combination therapy (≤ 2 months) is allowed only to facilitate transition to a single agent.
Pharmacotherapy (stimulants)
Clinical decisions should involve appropriate specialist input when indicated (e.g., sleep specialist for hypersomnolence).
Provider Actions, Documentation, and Prior Authorization
Prior authorization required (approvals up to 1 year)
Prior authorization is required for benefit coverage of ADHD stimulant medications; approvals for listed indications are provided for up to 1 year when criteria are met.
PA for branded/specialty ADHD stimulants unless exception met
Prior authorization is required for listed branded and specialty ADHD stimulant formulations unless the patient meets the swallowing‑impaired exception or satisfies the stepped‑therapy/prior‑trial pathway documented by the prescriber.
PA required for nonpreferred formulations with documented prior trials
Requests for branded or otherwise nonpreferred formulations require prior authorization and prescriber documentation of prior trials of the specified amphetamine or methylphenidate comparator products (bioequivalent generics or listed alternatives) per the product-specific criteria.
PA requires prior‑trial evidence of inadequate efficacy or intolerance
Prior authorization approvals require documentation that prior trials resulted in inadequate efficacy or significant intolerance (or that the patient cannot use the comparator) as attested by the prescriber.
Branded product trial expectations (bioequivalent generic and specific IR/ER trials)
For many branded products, prescribers must document trials of bioequivalent generics and trials of specific IR/ER methylphenidate or dexmethylphenidate products (or show inability to take the generic because of inactive‑ingredient differences) before branded product approval.
Step therapy: required trials of amphetamine ER and/or methylphenidate/dexmethylphenidate ER
Most branded/specialty stimulants require step therapy: prior trials of amphetamine mixed ER (generic for Adderall XR) and/or a dexmethylphenidate ER or methylphenidate ER product are required per product- and age‑specific rules.
Step therapy / required medication trials must be documented
Many branded products require documented trial and inadequate efficacy or intolerance to the specified generics (e.g., amphetamine mixed ER and a dexmethylphenidate or methylphenidate ER product) before approving the brand.
Required prior trials (failure or intolerance to listed alternatives)
Patients must have trialed and failed (or been intolerant to) the listed alternative stimulants (examples include dexmethylphenidate ER or methylphenidate ER and amphetamine IR/ER products) as detailed by product and age before approval for certain branded products.
Submit appropriate diagnosis/procedure codes or risk denial
When submitting claims or PA requests, providers must include appropriate diagnosis and procedure (billing) codes and use the most appropriate codes as of the submission date; claims not accompanied by covered codes will be denied as not covered.
Required documentation: age and prior stimulant therapy history
Prescriber documentation must state the patient’s age and a history of prior stimulant therapy including whether prior comparator products produced inadequate efficacy or significant intolerance, or evidence the patient cannot use comparator formulations.
Required supporting documentation: trial outcomes, allergies, swallowing issues
Supporting documentation should state which prior trials were attempted and whether there was inadequate efficacy or significant intolerance, and note allergies or inability to swallow when requesting ODT/chewable/liquid formulations.
Attestation of prior trials and outcomes required
Prescriber attestation is required that the patient tried and experienced inadequate efficacy OR significant intolerance with the specified prior stimulant products (products differ by age and therapy history) to meet prior‑trial criteria.
Claims without covered diagnosis/procedure codes will be denied
Claims or PA requests will be denied as not covered if submitted without covered diagnosis/procedure codes or if the request does not meet the policy criteria.
Denial triggers — unmet product criteria, prior‑trial or age mismatch
Requests may be denied if the patient does not meet the swallowing‑impaired pathway and also does not meet the stepped‑therapy/prior‑trial requirements for the specific product, including when required prior trials are not documented or age‑based criteria are unmet.
- Denial trigger when neither swallowing exception nor documented prior trials are present
- Denial trigger when age‑specific trial requirements are not met or documented
Conditions not covered — uses that will be denied
Stimulant products used for indications listed under 'Conditions Not Covered' (for example fatigue associated with MS, neuroenhancement, long‑term combination therapy with atomoxetine >2 months) are considered not medically necessary and may be denied.
Referenced Stimulant Products and Coding
| Adderall (IR/ER) | Adderall immediate-release and Adderall XR extended-release (prescribing information referenced) |
| Focalin XR / Focalin | dexmethylphenidate ER capsule and IR tablets (prescribing information referenced) |
| Ritalin / Ritalin LA | methylphenidate IR tablets and methylphenidate ER capsule (Ritalin LA) (prescribing information referenced) |
| Evekeo | amphetamine sulfate tablets (prescribing information referenced) |
| Vyvanse / Arynta | lisdexamfetamine capsules (Vyvanse) and Arynta oral solution (prescribing information referenced) |
| Adzenys XR-ODT | amphetamine extended-release orally disintegrating tablet (prescribing information referenced) |
| Relexxii | Relexxii (prescribing information referenced) |
| Zenzedi | Zenzedi tablets (prescribing information referenced) |
| Metadate CD | Metadate CD (prescribing information referenced) |
| Xelstrym / Daytrana | transdermal stimulant systems (prescribing information referenced) |
Background and Scope
Central nervous system stimulant medications are primarily indicated for treatment of ADHD; certain agents have additional FDA‑approved indications (for example, lisdexamfetamine for binge‑eating disorder) and some stimulants are indicated for narcolepsy or short‑term use in exogenous obesity (e.g., amphetamine sulfate tablets). This policy establishes the prior‑authorization requirement (approvals up to one year when criteria are met) and product‑specific medical necessity pathways used to determine coverage for stimulant products.
Key Definitions
Pharmacotherapy Options
Pharmacotherapy (stimulants)
Clinical decisions should involve appropriate specialist input when indicated (e.g., sleep specialist for hypersomnolence).
Revision History and Document Changes
Added criteria for dextroamphetamine immediate-release tablets, methylphenidate ER tablets (45mg, 63mg, 72mg), Relexxii, and Zenzedi (effective 2024-04-01).
Added criteria for Metadate CD (effective 2024-09-15).
Removed methylphenidate extended-release capsules (generic for Aptensio XR) from the list of alternatives in the preferred product criteria for Metadate CD, certain methylphenidate ER tablets, and Relexxii (effective 2025-07-01).
Added Adzenys XR-ODT and generic amphetamine extended‑release orally disintegrating tablets; updated preferred product and Vyvanse requirements (effective 2026-02-15).
Added multiple products including Adderall, Adderall XR, Aptensio XR, Azstarys, Concerta, Cotempla XR ODT, Desoxyn, and Dexedrine (effective 2026-05-15).
Removed a phrase under 'Long-Term Combination Therapy' for clarity and updated the Xelstrym preferred product requirement (effective 2026-07-01).
Added Arynta (lisdexamfetamine oral solution) with the same approval criteria as lisdexamfetamine capsules (Vyvanse) (effective 2026-08-01).
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