2025 Drug List (Pharmacy Benefit) — Coverage Criteria
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Defines the pharmacy drug list (covered drugs, tiers, special requirements, and processes) for Blue Cross and Blue Shield of Oklahoma members and their prescribing providers; applies to drugs covered under the pharmacy benefit and guidance on specialty drugs, prior authorization, step therapy, quantity limits, and exceptions.
No material clinical or coverage changes in this revision.
Coverage Criteria & Formulary Listing
Pharmacy benefit coverage general criteria
Covered when ALL of the following are met
Drugs not shown on the drug list are not covered unless an exception is approved
Non‑FDA‑approved drugs are not covered per plan guidance
Refer to individual plan materials or MyPrime.com for specifics
General coverage constraints
Coverage and dispensing subject to listed requirement flags and quantity limits
Examples in the drug list: HARVONI (PA, QL 30 tablets/30 days, SP); ISENTRESS (QL 60 tablets/30 days); MAVYRET pellet pack (PA, QL) and VOSEVI (PA, QL 30 tablets/30 days, SP).
Formulary listing with utilization management codes
Coverage stance is conveyed via Drug Tier and Requirements/Limits entries for each listed product
This section presents per‑product annotations; no additional clinical decision logic is embedded in these entries.
Formulary entries with product-specific requirements
Drugs are listed with tier and specific Requirements/Limits; coverage depends on those annotations.
Coverage and any PA/QL/AC indicated per product lines in the drug list
Formulary coverage listing
Coverage and management by product/formulation as listed
This content set is a formulary catalog; medical necessity criteria beyond the listed annotations are not provided in these chunks.
Coverage for pharmacy benefit drugs is determined by whether the product is included on the payer's Drug List or has an approved exception. The plan may not cover drugs not shown on the Drug List. In addition, the plan's benefit materials note that over-the-counter equivalents, compounded medications, repackaged medications, and non–FDA‑approved drugs may not be covered; providers and members should refer to the member's specific benefit plan or call the number on the ID card for clarification or to request an exception.
The extracted formulary segments are presented as product listings with Drug Tier and Requirements/Limits flags; they do not contain a separate exclusions section. In other words, within the cited chunks there are no explicit exclusions listed — non‑coverage is primarily implied when a drug is absent from the Drug List rather than by named exclusion rules in these chunks.
The document excerpts show product lines annotated with tier and requirement flags but do not contain separate clinical exclusion rules in the cited chunks. There are no explicit clinical exclusions stated in these chunks; coverage limitations are conveyed by per‑product annotations such as PA, QL, SP, or AC rather than by standalone clinical exclusion statements.
The listed entries in these chunks are formulary lines with Drug Tier and Requirements/Limits annotations. They do not set out clinical coverage criteria (for example, specific diagnosis, prior‑therapy failure, or lab thresholds). Therefore, in the cited material there are no explicit clinical coverage criteria
The document extract conveys coverage stance via Drug Tier and Requirements/Limits fields and per‑product QL/PA/SP annotations, but it does not include a medical‑necessity decision algorithm in these chunks. There are no explicit medical necessity criteria described here; providers should follow the PA process and supply supporting clinical documentation when a PA is required.
Dispensing and quantity limits are enforced at claim adjudication. The plan notes that dispensed quantities beyond stated dispensing/quantity limits may be denied, and for certain controlled substances state law may prohibit coverage if the dispensed quantity exceeds the limit; in such cases the member would be responsible for the full cost of the excess medication. Providers should confirm per‑product QL values and follow prior authorization procedures when requesting quantities beyond listed limits.
Within the cited chunks there are no lines that explicitly state 'not medically necessary' determinations for specific clinical scenarios. The document communicates management via per‑product flags (e.g., PA, QL, SP) but does not include named 'not medically necessary' rulings in these excerpts.
The segments reviewed do not list specific conditions or situations labeled as 'not medically necessary.' Coverage is determined by whether a drug is on the Drug List and by the product's Requirements/Limits entries; explicit non‑medical‑necessity statements are not present in these chunks.
Coding, Quantity Examples & Limits
| No codes listed |
| No codes listed |
Provider Actions — Prior Authorization, Step Therapy, Documentation
Prior Authorization Required
Prior Authorization (PA) may be required for many drugs across categories (antifungals, antivirals, HCV agents, specialty oncology agents, biologics, select specialty products, PA‑marked or PA‑designated drugs). When PA is required the prescriber must submit a prior authorization request and receive approval before the medication will be covered. Failure to obtain required PA, exceed quantity limits, or omit required PA/QL/SP documentation may result in denial of coverage and member financial liability.
- PA applies to many specialty oncology agents (examples marked PA/QL/SP next to agent names in the Drug List).
- Selected antifungals and other specialty antimicrobials are PA‑designated (e.g., BREXAFEMME = PA, CRESEMBA = PA).
- Selected antivirals and HCV agents are subject to PA and QL (e.g., HARVONI = PA, MAVYRET = PA where noted).
- PA is required for PA‑marked or PA‑designated drugs across the formulary; check the Special Requirements column for 'PA'.
- Certain biologics and specialty drugs require PA and often have QL and SP (e.g., REPATHA = PA, QL; NUCALA = PA, QL, SP; FASENRA = PA, QL, SP).
- TRYVIO is PA and has QL (TRYVIO: PA, QL 30 tablets/30 days).
- Colesevelam oral suspension packets are PA and have QL (Colesevelam packet: PA, QL 30 packets/30 days).
- REPATHA (evolocumab) requires PA and has quantity limits (6 syringes/pens per 28 days as listed).
- Dispensed quantities beyond posted dispensing/quantity limits may be denied; members are responsible for full cost if provider dispenses beyond limits without coverage.
- PA / Specialty Pharmacy (SP) / Quantity Limit (QL) triggers are indicated in the Drug List Special Requirements column (PA, SP, QL, ST, AC).
- Noncompliance with QL or PA/SP requirements at claim submission may result in denial at point of adjudication.
- PA, QL, or SP omissions on the prior authorization submission can trigger denial or delays — include required documentation.
- Some formulations or routes have separate PA/QL requirements (e.g., oral solutions, packets, starter/therapy packs).
- FUROSCIX, droxidopa and other specialty products have explicit PA/QL entries (FUROSCIX = PA, QL; droxidopa = PA, QL).
- Specialty biologics and high-cost agents routinely have PA, QL and specialty pharmacy requirements and require supporting clinical documentation.
- Selected specialty agents (e.g., PROCYSBI, FILSPARI, ALYFTREK) are PA‑flagged and have QL/SP designations.
- Quantity limits are enforced and documented at claim; common QL examples are shown next to agent names (e.g., QL (30 tablets/30 days)).
- Specialty pharmacy note: many SP-designated products must be dispensed via an approved specialty pharmacy as noted in the Drug List.
- Vaccine entries include administrative coverage notes (AC) — providers should follow vaccine administrative coverage documentation and billing guidance.
- PALFORZIA and similar products have specialty dispensing requirements (SP) — follow the Drug List for level-specific SP designations.
- Providers or members must submit a Drug List exception (see Exception Process) when a drug is not on the Drug List; call the number on the member ID card.
- PA submission expectations: submit clinical documentation supporting medical necessity, prior treatment history or step therapy trials when required, and any specialty pharmacy enrollment documentation.
- NUCALA (mepolizumab) requires PA and QL with SP and has specific documentation requirements for coverage (dose/formulation distinction).
Initiation & Initial Dispensing Controls
Initiation controls for selected antidiabetics/GLP‑1s
Utilization controls applicable at initiation for certain agents
Providers must submit PA requests where indicated prior to initial dispensing
Initial dispensing limits
Quantity limits for initial dispensing where specified
These are formulary QL entries; specific clinical initiation criteria are not provided in these chunks.
Step Therapy — Presence and Examples
| Product / Class | Step Therapy (ST) status | Notes |
|---|---|---|
| Antivirals / HIV & HCV agents (e.g., HARVONI, ISENTRESS, MAVYRET, PAXLOVID) | not_covered | No explicit step-therapy sequences listed; products are managed via PA, QL, and SP flags (e.g., HARVONI = PA, QL 30 tablets/30 days, SP; ISENTRESS = QL 60/180 packets). |
| Scope | Step Therapy (ST) | Coverage controls |
|---|---|---|
| General product listings where no explicit ST sequence provided | not_covered | Coverage indicated by PA, QL, and SP flags rather than ordered step requirements; prescribers must follow PA/QL/SP as listed per product lines. |
| Oncology / Specialty oncology agents | Step Therapy (ST) status | Provider action |
|---|---|---|
| Multiple oral antineoplastics (e.g., abiraterone, ALECENSA, IBRANCE, others) | neutral | Prior authorization required for many oncology/specialty oral agents (Requirements/Limits include PA, QL, SP); explicit step-therapy sequences are not provided in the listing — PA must be obtained where indicated. |
| Product groups | Step Therapy (ST) | Management flags |
|---|---|---|
| Assorted agents across extract (multiple classes) | not_covered | No explicit step therapy sequences captured; products show per-product PA and QL entries (e.g., IBRANCE = PA, QL 21 capsules/28 days, SP). |
| Contraceptives / Related products | Administrative Controls (AC) present | Notes |
|---|---|---|
| Contraceptive products (e.g., ANNOVERA, AVERI, various OCPs) | neutral | Several contraceptives are labeled AC or AC + QL (e.g., ANNOVERA = AC QL 1 ring/365 days; other OCPs show AC and QL 28 tablets/21 days), indicating administrative coverage controls rather than explicit ST sequences. |
| GLP‑1 / Weight‑management agents | Step Therapy (ST) status | Utilization controls |
|---|---|---|
| GLP‑1 and weight-management agents (e.g., MOUNJARO, OZEMPIC, RYBELSUS) | not_covered | PA is required for selected presentations (e.g., MOUNJARO = PA, QL 4 pens/28 days; OZEMPIC = PA, QL 1 pen/28 days or specified mL limits). No multi-step failure sequences are specified in the extract. |
| KERENDIA (finerenone) / related agents | Step Therapy (ST) status | Reference |
|---|---|---|
| KERENDIA and selected products noted in listing | covered | KERENDIA is indicated with 'ST' in Requirements/Limits in the listing — prescribers should follow step therapy where ST is listed. (ST flags appear in product Requirements/Limits.) |
| Various formulary entries | Step Therapy (ST) presence | Remarks |
|---|---|---|
| Cardiovascular / miscellaneous (diltiazem, felodipine, nisoldipine, etc.) | not_covered | No explicit step-therapy sequences are specified in these chunks; products are listed with tiering and occasional PA/QL flags but not ordered ST steps. |
| Pulmonary / Cardiology specialty agents | Step Therapy (ST) status | Management |
|---|---|---|
| Pulmonary/cardiology specialty agents (e.g., XOLAIR, ALYFTREK, REPATHA) | not_covered | Many pulmonary and specialty cardiology drugs are designated SP and require PA/QL (e.g., XOLAIR = PA, SP; ALYFTREK = PA, QL, SP; REPATHA = PA, QL). No explicit step-therapy failure sequences are provided in the listing. |
| General observation | Step Therapy (ST) implication | Plan |
|---|---|---|
| Overall extract coverage | not_covered | The document generally lacks explicit step-therapy algorithms; coverage and utilization management are implemented via per-product PA, QL, SP, and occasional ST flags. Providers must follow the Requirements/Limits shown for each product. |
| Programmatic controls (SP/PA) | Step Therapy (ST) inference | Notes |
|---|---|---|
| Products marked SP/PA across listing | neutral | SP and PA designations imply specialty program management and prior-approval requirements but do not specify an ordered step-failure requirement; such program controls may functionally act as utilization management without explicit ST sequences. |
| Antidepressants / Related agents | Step Therapy (ST) status | Example entries |
|---|---|---|
| Selected antidepressants and related products (e.g., AUVELITY, citalopram, FETZIMA, TRINTELLIX) | covered | Several antidepressants are designated 'ST' in Requirements/Limits (e.g., AUVELITY = ST; citalopram = QL 30/30 days, ST; FETZIMA = ST; TRINTELLIX = ST), indicating step therapy policies apply where noted. |
| Prescriber responsibility | When ST is listed | Action required |
|---|---|---|
| Products flagged with 'ST' in Requirements/Limits (various classes) | covered | When a product listing includes 'ST', the prescriber must follow the step therapy requirement indicated in the product's Requirements/Limits; the source lists ST flags for several products but does not provide detailed prior-failure sequences in the extract. |
Quantity Limits — Product Examples
Site of Care & Specialty Pharmacy
Definitions & Notation
Background & Scope
Specialty drugs are handled differently from standard retail medications: they may be oral, topical, or injectable and can be either self‑administered or provider‑administered. Provider‑administered products may fall under the medical benefit rather than the pharmacy benefit. The plan selects drugs for the list based on committee review considering safety, efficacy, cost, and FDA regulation. For specialty products the formulary uses annotations such as SP (specialty pharmacy), PA (prior authorization), and QL (quantity limits) to indicate additional management, and some specialty products will require dispensing through a specialty pharmacy or infusion/clinic setting as indicated.
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