Clinical UM PPO Guidelines for California (Catalog of Clinical Utilization Management Guidelines)
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A catalog of Clinical UM PPO Guidelines adopted for Anthem Blue Cross California commercial plans, describing which guideline documents are used for utilization management and which services may require prior authorization; applies to providers requesting precertification for affected members.
No material clinical or coverage changes in this revision.
Coverage Criteria / Applicability
This index of Clinical Utilization Management (UM) guidelines applies to local fully‑insured Anthem Blue Cross members and select self‑insured (ASO) groups whose services are medically managed as part of a purchased program. It does not apply to BlueCard®, Medicare Advantage, Medicaid, Medicare Supplement, or the Federal Employee Program (FEP®).
Provider Actions and Authorization Requirements
Prior authorization required for listed UM guideline services
Certain services listed in the adopted Clinical UM Guideline index require prior authorization; examples called out in the document include monitored anesthesia for gastrointestinal endoscopic procedures and upper gastrointestinal endoscopy, radiation therapy (including proton beam therapy and other radiation categories), select cardiology procedures (e.g., diagnostic coronary angiography, percutaneous coronary intervention, implantable devices, ablation, ambulatory cardiac rhythm monitoring), select imaging categories, and other guideline-specified services. Prior authorization review may be performed for select accounts using the Anthem Clinical UM Guidelines.
- Monitored Anesthesia Care for GI endoscopic procedures and upper GI endoscopy: CG-MED-34 and CG-MED-59 reference prior authorization and implementation dates.
- Radiation therapy categories (Radiation Therapy excluding Proton; Proton Beam Therapy) are listed with implementation dates and referenced Carelon radiation oncology guidelines.
- Cardiology procedures (Diagnostic Coronary Angiography, Percutaneous Coronary Intervention, Implantable Cardioverter Defibrillators, Permanent Implantable Pacemakers, Cardiac Resynchronization Therapy, various ablation procedures, Ambulatory Cardiac Rhythm Monitoring) appear in the guideline index and may be subject to prior authorization review for select accounts.
Drugs listed under CC- guidelines are managed by UM and may require step edits
Multiple drug-specific Clinical Guideline (CC-) entries are managed under the UM program and are subject to clinical review and prior authorization per their individual guidelines; these include agents such as Exondys 51 (eteplirsen), Spinraza (nusinersen), Krystexxa (pegloticase), growth hormone therapies, tumor necrosis factor antagonists, ustekinumab, interleukin inhibitors, hemophilia agents, and others.
- Each CC- guideline entry (e.g., CC-0044 Exondys 51; CC-0048 Spinraza; CC-0057 Krystexxa; CC-0068 Growth Hormone; CC-0062 Tumor Necrosis Factor Antagonists; CC-0063 Ustekinumab) indicates the drug is subject to UM review and prior authorization per that guideline.
- Drug management may include step edits or review processes as specified in the individual CC- guideline implementation entries.
Precertification notification and contact
When a provider requests precertification, the provider will be notified if precertification is required for the member; if the program has not been purchased for that member’s plan, precertification is not required and clinical review will not be performed. For more information, contact the phone number on the back of the member’s ID card.
- Notification occurs at the time the provider requests precertification.
- Contact information for precertification questions is the phone number on the member ID card.
Precertification and pre-payment review triggers
Claims may be reviewed or subject to pre-payment review if a provider’s billing practices are not consistent with peers or when Clinical Guidelines approved by MPTAC (but not included in the standard adopted list) are used for provider education; the determination for precertification is made when requesting precertification and prior authorization review may be performed for select accounts.
- Pre-payment review can be triggered by billing practice variance (frequency or other inconsistencies compared with peers).
- Guidelines approved by MPTAC but not in the adopted list may be used for provider education or to review claims for select purposes.
- Precertification requirement is determined at the time of the precertification request; select accounts may be subject to Anthem Clinical UM Guideline prior authorization review.
Background and Scope
This document is an index/catalog of Clinical UM guidelines adopted for Anthem Blue Cross California commercial PPO plans. It identifies guideline numbers, titles, and implementation details used for utilization management across a broad range of services and drug therapies and indicates when prior authorization or clinical review processes may be required. Providers will be notified at the time of a precertification request if precertification is required for the member; if an employer has not purchased the program, precertification is not required and clinical review will not be performed. For additional information or to confirm applicability, contact the phone number on the back of the member's ID card.
Step Therapy / Drug-Specific Guidelines
| Clinical Guideline (CG) Number | Drug / Class | Implementation Date (CA PPO) | Notes / Special Notes |
|---|---|---|---|
| {"text":"CC-0044","status":""}|{"text":"Exondys 51 (eteplirsen)","status":""}|{"text":"Implementation Date = 3/1/2017 (CA PPO)","status":""}|{"text":"","status":""} | |||
| {"text":"CC-0045","status":""}|{"text":"Increlex (mecasermin)","status":""}|{"text":"Implementation Date = 10/1/2016 (CA PPO)","status":""}|{"text":"","status":""} | |||
| {"text":"CC-0046","status":""}|{"text":"Zinplava (bezlotoxumab)","status":""}|{"text":"Implementation Date = 5/1/2017 (CA PPO)","status":""}|{"text":"","status":""} | |||
| {"text":"CC-0048","status":""}|{"text":"Spinraza (nusinersen)","status":""}|{"text":"Implementation Date = 5/1/2017 (CA PPO)","status":""}|{"text":"","status":""} | |||
| {"text":"CC-0049","status":""}|{"text":"Radicava (edaravone)","status":""}|{"text":"Implementation Date = 10/1/2017 (CA PPO)","status":""}|{"text":"","status":""} | |||
| {"text":"CC-0050","status":""}|{"text":"Monoclonal Antibodies to Interleukin-23","status":""}|{"text":"Implementation Date = 1/1/2018 (CA PPO)","status":""}|{"text":"","status":""} | |||
| {"text":"CC-0051","status":""}|{"text":"Enzyme Replacement Therapy for Gaucher Disease","status":""}|{"text":"Implementation Date = prior to 1/1/16 (CA PPO)","status":""}|{"text":"","status":""} | |||
| {"text":"CC-0057","status":""}|{"text":"Krystexxa (pegloticase)","status":""}|{"text":"Implementation Date = 1/1/2017 (CA PPO)","status":""}|{"text":"","status":""} | |||
| {"text":"CC-0061","status":""}|{"text":"Octreotide Agents","status":""}|{"text":"Implementation Date = 1/15/2016 (CA PPO)","status":""}|{"text":"","status":""} | |||
| {"text":"CC-0062","status":""}|{"text":"Tumor Necrosis Factor Antagonists","status":""}|{"text":"Implementation Date = 12/28/2017 (CA PPO)","status":""}|{"text":"","status":""} | |||
| {"text":"CC-0063","status":""}|{"text":"Ustekinumab","status":""}|{"text":"Implementation Date = 12/28/2017 (CA PPO)","status":""}|{"text":"","status":""} | |||
| {"text":"CC-0064","status":""}|{"text":"Interleukin-1 Inhibitors","status":""}|{"text":"Implementation Date = 12/28/2017 (CA PPO)","status":""}|{"text":"","status":""} | |||
| {"text":"CC-0065","status":""}|{"text":"Agents for Hemophilia and von Willebrand Syndrome","status":""}|{"text":"Implementation Date = 12/28/2017 (CA PPO)","status":""}|{"text":"","status":""} | |||
| {"text":"CC-0066","status":""}|{"text":"Monoclonal Antibodies to Interleukin-6","status":""}|{"text":"Implementation Date = 12/28/2017 (CA PPO)","status":""}|{"text":"","status":""} | |||
| {"text":"CC-0068","status":""}|{"text":"Growth Hormone","status":""}|{"text":"Implementation Date = 5/1/2018 (CA PPO)","status":""}|{"text":"","status":""} | |||
| {"text":"CC-0069","status":""}|{"text":"Egrifta (tesamorelin)","status":""}|{"text":"Implementation Date = 5/1/2018 (CA PPO)","status":""}|{"text":"","status":""} | |||
| {"text":"CC-0071","status":""}|{"text":"Entyvio (vedolizumab)","status":""}|{"text":"Implementation Date = 5/1/2018 (CA PPO)","status":""}|{"text":"","status":""} | |||
| {"text":"CC-0072","status":""}|{"text":"Vascular Endothelial Growth Factor (VEGF) Inhibitors","status":""}|{"text":"Implementation Date = 6/28/2018 (CA PPO)","status":""}|{"text":"","status":""} | |||
| {"text":"CC-0073","status":""}|{"text":"Alpha-1 Proteinase Inhibitor Therapy","status":""}|{"text":"Implementation Date = 6/28/2018 (CA PPO)","status":""}|{"text":"","status":""} | |||
| {"text":"CC-0074","status":""}|{"text":"Akynzeo (fosnetupitant and palonosetron) for injection","status":""}|{"text":"Implementation Date = 5/1/2019 (CA PPO)","status":""}|{"text":"","status":""} | |||
| {"text":"CC-0075","status":""}|{"text":"Rituximab agents for Non-Oncologic Indications","status":""}|{"text":"Implementation Date = 6/28/2018 (CA PPO)","status":""}|{"text":"","status":""} | |||
| {"text":"CC-0076","status":""}|{"text":"Nulojix (belatacept)","status":""}|{"text":"Implementation Date = 6/28/2018 (CA PPO)","status":""}|{"text":"","status":""} | |||
| {"text":"CC-0077","status":""}|{"text":"Palynziq (pegvaliase-pqpz)","status":""}|{"text":"Implementation Date = 5/1/2019 (CA PPO)","status":""}|{"text":"","status":""} | |||
| {"text":"CC-0078","status":""}|{"text":"Orencia (abatacept)","status":""}|{"text":"Implementation Date = 9/20/2018 (CA PPO)","status":""}|{"text":"","status":""} | |||
| {"text":"CC-0079","status":""}|{"text":"Strensiq (asfotase alfa)","status":""}|{"text":"Implementation Date = 9/20/2018 (CA PPO)","status":""}|{"text":"","status":""} | |||
| {"text":"CC-0081","status":""}|{"text":"Crysvita (burosumab-twza)","status":""}|{"text":"Implementation Date = 5/1/2019 (CA PPO)","status":""}|{"text":"","status":""} | |||
| {"text":"CC-0082","status":""}|{"text":"Onpattro (patisiran)","status":""}|{"text":"Implementation Date = 5/1/2019 (CA PPO)","status":""}|{"text":"","status":""} | |||
| {"text":"CC-0085","status":""}|{"text":"Actimmune (interferon gamma-1b)","status":""}|{"text":"Implementation Date = 6/28/2018 (CA PPO)","status":""}|{"text":"","status":""} | |||
| {"text":"CC-0086","status":""}|{"text":"Spravato (esketamine) Nasal Spray","status":""}|{"text":"Implementation Date = 9/1/2019 (CA PPO)","status":""}|{"text":"","status":""} | |||
| {"text":"CC-0087","status":""}|{"text":"Gamifant (emapalumab-lzsg)","status":""}|{"text":"Implementation Date = 9/1/2019 (CA PPO)","status":""}|{"text":"","status":""} |
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