Ultraviolet Light Therapy for Skin Conditions
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This policy addresses use of targeted phototherapy (eg, excimer laser, localized NB-UVB) for treatment of mild, treatment-resistant, and moderate-to-severe localized psoriasis and describes the clinical evidence and intended populations; it applies to Blue Cross Blue Shield of Kansas members and treating dermatology/primary care providers.
No material clinical or coverage changes in this revision.
Coverage Criteria
Treatment-Resistant Mild Psoriasis
Covered when ALL of the following are met
Evidence includes small within-subject studies (N<60) showing improvement with targeted phototherapy; targeted therapy is presumed to have equal or lower risk than whole-body UVB due to limited skin exposure
Moderate-to-Severe Localized Psoriasis
Considered when ALL of the following are present
Systematic reviews of small controlled trials (N≤25) show targeted phototherapy has efficacy similar to whole-body phototherapy
Evidence-based coverage groupings
Covered when clinical evidence supports use and patient meets disease-severity/context considerations
Evidence includes small RCTs and prospective studies (N≤25); considered sufficient for meaningful improvement.
Randomized trials reported higher clearance rates and longer remission with PUVA (e.g., pooled analysis by Archier et al; El-Mofty et al trial).
Evidence includes systematic reviews and RCTs comparing excimer laser/lamp to NB-UVB and other comparators; outcomes and adverse events vary by study.
Evidence considerations
Evidence summary and considerations
Trials include adults and pediatric patients; responses vary by lesion location, disease duration, age, and Fitzpatrick skin type.
Potential advantage: higher localized doses and limited surrounding exposure; studied devices include excimer lamps and lasers.
NB-UVB is the standard comparator/standard of care for widespread disease; many trials compare targeted devices to NB-UVB or topical agents.
Systematic reviews report mixed results: some meta-analyses show similar outcomes versus NB-UVB, while others suggest higher likelihood of ≥50% repigmentation with excimer laser; adverse events such as burning and blistering have been reported.
Example: Fa et al retrospective series (979 patients) reported 39% of lesions reached ≥51% repigmentation and a 44% recurrence rate among cured lesions; RCTs and systematic reviews vary in precision and geographic settings.
Coverage criteria for phototherapy modalities
Covered when ALL of the following are met
PUVA may be considered particularly for darker Fitzpatrick skin phototypes or treatment-resistant vitiligo per Vitiligo Working Group guidance; evidence includes RCTs and systematic reviews.
Vitiligo Working Group: targeted phototherapy can be considered when <10% BSA affected (level II evidence); targeted approaches aim to concentrate therapy on limited areas.
Meta-analyses indicate NB-UVB often achieves equal or higher repigmentation rates than PUVA and is associated with fewer systemic adverse events; use NB-UVB as primary comparator when assessing modality choice.
The American Academy of Dermatology does not recommend phototherapy for patients with mild localized psoriasis whose disease can be controlled with topical medications (for example, topical steroids, coal tar, vitamin D analogues, tazarotene, anthralin). Targeted phototherapy is intended for patients with lesions that are resistant to topical therapy or when whole-body UV exposure is not appropriate; it is not first-line for disease controllable with topicals.
Randomized trials and systematic reviews indicate that PUVA (psoralen plus UVA) can be more effective than NB-UVB or topical therapies for moderate-to-severe psoriasis. Because of its side-effect profile, PUVA is typically reserved for more severe disease and is not routinely used for mild localized psoriasis.
Adverse events reported with targeted phototherapy across systematic reviews and trials include blistering, burning, stinging, moderate-to-severe erythema, itching, and edema. Some studies specifically noted increases in blistering with targeted devices and also reported itching and burning in both treatment and control groups.
The list of procedure and device codes in this policy is provided for information only. The presence or absence of a code in the document does not by itself determine coverage; medical necessity and member contract benefits govern coverage decisions.
Inclusion or exclusion of specific procedure, diagnosis, or device codes in this policy does not constitute or imply that a service is covered or reimbursable. Coverage determinations depend on whether the service meets the Policy section medical necessity criteria and the member's contract benefits.
Clinical guidance indicates that phototherapy is not recommended for patients with mild localized psoriasis when disease is controllable with topical medications; in such cases, requests for phototherapy may be denied as not indicated while topical therapy remains effective.
Within the portions of the document addressing targeted phototherapy and PUVA, there are no explicit statements that label particular uses as definitively not medically necessary beyond guidance recommending against phototherapy when topical treatments control mild disease.
The extract does not provide a formal list of conditions that are explicitly designated not medically necessary for targeted phototherapy. Adverse events are described, but they are not framed as automatic exclusions for therapy.
The policy highlights that therapies lacking robust, well-designed comparative evidence or with outcomes inferior to standard therapy may be less preferred. For example, meta-analytic and trial data indicate NB-UVB often achieves equal or higher repigmentation rates than PUVA, and where evidence favors a standard therapy, alternatives with inferior outcomes are noted as not preferred.
Procedure and device codes referenced in this policy include CPT/HCPCS codes for actinotherapy, PUVA, excimer laser treatment (by area), ultraviolet light therapy systems, and an unspecified oral chemotherapeutic code — a total of 10 codes are listed for informational purposes.
| 96900 | Actinotherapy (ultraviolet light) |
| 96912 | Photochemotherapy; psoralens, and ultraviolet A (PUVA) |
| 96920 | Excimer Laser treatment for (psoriasis); total area less than 250 sq cm |
| 96921 | Excimer Laser treatment for (psoriasis); Total area 250-500 sq cm |
| 96922 | Excimer Laser treatment for (psoriasis); Total area over 500 sq cm |
| E0691 | Ultraviolet light therapy system, includes bulbs/lamps, timer and eye protection; treatment area 2 sq ft or less |
| E0692 | Ultraviolet light therapy system panel, includes bulbs/lamps, timer and eye protection, 4 ft panel |
| E0693 | Ultraviolet light therapy system panel, includes bulbs/lamps, timer and eye protection, 6 ft panel |
| E0694 | Ultraviolet multidirectional light therapy system in 6 ft cabinet, includes bulbs/lamps, timer, and eye protection |
| J8999 | Prescription drug, oral, chemotherapeutic, not otherwise specified |
Provider Actions and Prior Authorization
Prior authorization required for targeted phototherapy in topical‑resistant mild psoriasis
Targeted phototherapy may be considered for patients with mild psoriasis that is resistant to topical medications; obtain prior authorization that documents failure of topical therapies and that targeted phototherapy is being used as an alternative to whole‑body UVB.
- Document prior topical therapy attempts and inadequate response.
- State that targeted phototherapy is chosen to avoid whole‑body UVB exposure.
Prior authorization recommended for PUVA in moderate‑to‑severe psoriasis
PUVA is typically reserved for more severe or generalized psoriasis and prior authorization should be obtained when used for patients with >10% body surface area involvement or refractory disease.
- Indicate % body surface area or clinical justification for moderate‑to‑severe designation.
- Provide prior treatment history showing refractory disease.
Contact BCBSKS for prior authorization guidance
For coverage questions or if prior authorization requirements are unclear, contact Blue Cross and Blue Shield of Kansas customer service or your professional/institutional relations representative; the policy extract does not provide a specific prior authorization form.
- No explicit prior authorization form is provided in this policy text—use BCBSKS contact channels for guidance.
Prior authorization may be required for listed phototherapy procedures/devices
Certain ultraviolet therapies and devices are listed with procedure and HCPCS codes; prior authorization may be required per the member's contract and medical necessity criteria.
Codes listed only if Policy criteria and member benefits are met
The procedure and HCPCS codes listed in the policy are informational; coverage is contingent on meeting the Policy section requirements and the member's contract—codes are medically necessary only if the procedure is performed according to the Policy.
- Do not assume inclusion of a code guarantees coverage or reimbursement.
- Ensure treatments meet Policy criteria to support medical necessity for billed codes.
Step therapy: require topical therapy trial before targeted phototherapy
Topical medications (e.g., topical steroids, vitamin D analogues, tazarotene, coal tar) are first‑line for mild localized psoriasis; targeted phototherapy is considered only after lesions are resistant to topical therapy.
- Document trials of appropriate topical agents and inadequate response before initiating targeted phototherapy.
Step therapy: document escalation before PUVA
Evidence indicates PUVA can be more effective than NB‑UVB and topical steroids for moderate‑to‑severe psoriasis; therefore, step therapy may require trial and failure of less intensive therapies before authorization of PUVA.
- Provide documentation of prior NB‑UVB or topical therapy trials and outcomes when requesting PUVA.
Comparator: NB‑UVB is standard of care
The standard comparator for targeted phototherapy in the evidence base is narrowband UVB (NB‑UVB) light box therapy; topical medications and NB‑UVB are the current comparators to describe prior treatment and sequencing.
- When describing prior therapy, note whether NB‑UVB was tried or considered as the standard comparator.
Therapy sequencing: reserve PUVA for after conservative therapy fails
PUVA is considered an alternative when conservative therapy fails; NB‑UVB is the most described standard and should be considered in sequencing before more toxic options.
- Explain why PUVA is chosen over NB‑UVB for individual patients when submitting authorization.
Follow current BCBSKS policy and member contract for sequencing
Follow the current policy criteria and payer guidance for stepwise treatment requirements; policy history has revised medically necessary statements and limits over time, so rely on the active policy and BCBSKS direction.
- Verify the most recent policy version and applicable member contract before submitting requests.
Documentation: baseline and long‑term follow‑up required
Document baseline disease status, prior topical treatments and responses, and follow‑up assessments (symptoms, disease status, quality of life, and treatment‑related morbidity); typical follow‑up for mild localized psoriasis occurs months to years after starting treatment.
- Record baseline lesion counts/locations and previous topical regimens and durations.
- Include follow‑up notes addressing response and adverse events over months to years.
Document clinical details consistent with study selection criteria
Align documentation with the populations and outcomes used in study selection: record disease extent (e.g., generalized >10% BSA where relevant), interventions tried, comparators, outcomes, and prespecified clinical endpoints.
- For generalized psoriasis, document % BSA (threshold >10% where applicable).
- Support clinical indication with evidence‑aligned data (PASI scores, repigmentation, etc.) when available.
Document number of treatment sessions and follow‑up (retrospective study benchmarks)
Retrospective studies report number of treatment sessions and follow‑up (examples: 10 sessions; 16–20 sessions; mean 20 sessions); include the number of sessions delivered and follow‑up duration in clinical records.
- Record total number of treatment sessions and timing when submitting outcomes or appeals.
- If using retrospective study benchmarks, note session counts (e.g., 16–20 treatments) and observed outcomes.
Medical necessity documentation: retain records showing adherence to Policy
To support medical necessity, document that the procedure was performed according to the Policy section and retain records of treatment modality, number of sessions, indication, and response.
- Include explicit statement that the service met Policy criteria when submitting claims or appeals.
- Keep treatment logs, session counts, and clinician assessments in the record.
Billing rule: codes are medically necessary only with Policy‑compliant performance
The listed codes are medically necessary only if the procedure is performed according to the Policy section; ensure that coding matches documented adherence to policy criteria to avoid coverage denials.
- Cross‑check billed CPT/HCPCS codes with documented indication and Policy adherence.
- Be aware that inclusion of codes in the policy does not itself guarantee coverage.
Denial risk: do not use phototherapy if topical therapy adequately controls disease
Phototherapy is not recommended for patients with mild localized psoriasis whose disease can be controlled with topical medications; initiating phototherapy in such cases may lead to coverage denial.
- If topical therapy controls disease, avoid phototherapy or document clear clinical rationale for escalation.
Contact BCBSKS for coverage inquiries and denial handling
For questions about coverage or potential denials, contact Blue Cross and Blue Shield of Kansas customer service or your professional/institutional relations representative for assistance.
- Use BCBSKS contact channels for pre‑authorization clarifications or appeals.
Policy monitoring: no scheduled update; BCBSKS will monitor literature
Blue Cross and Blue Shield of Kansas will continue to monitor the literature; there is no scheduled review or update—contact BCBSKS for updates if needed.
- Providers should rely on current policy language and BCBSKS contacts for the latest guidance.
Coding inclusion does not guarantee coverage or reimbursement
Inclusion or exclusion of procedure, diagnosis, or device codes in the policy is informational and does not guarantee member coverage or provider reimbursement; coverage decisions remain subject to the policy's medical necessity criteria and the member's contract.
- Verify member benefits and document Policy compliance to support coverage.
Definitions
Coding
| 96900 | Actinotherapy (ultraviolet light) |
| 96912 | Photochemotherapy; psoralens, and ultraviolet A (PUVA) |
| 96920 | Excimer Laser treatment for (psoriasis); total area less than 250 sq cm |
| 96921 | Excimer Laser treatment for (psoriasis); Total area 250-500 sq cm |
| 96922 | Excimer Laser treatment for (psoriasis); Total area over 500 sq cm |
| E0691 | Ultraviolet light therapy system, includes bulbs/lamps, timer and eye protection; treatment area 2 sq ft or less |
| E0692 | Ultraviolet light therapy system panel, includes bulbs/lamps, timer and eye protection, 4 ft panel |
| E0693 | Ultraviolet light therapy system panel, includes bulbs/lamps, timer and eye protection, 6 ft panel |
| E0694 | Ultraviolet multidirectional light therapy system in 6 ft cabinet, includes bulbs/lamps, timer, and eye protection |
| J8999 | Prescription drug, oral, chemotherapeutic, not otherwise specified |
| 96900 | Actinotherapy (ultraviolet light) |
| 96912 | Photochemotherapy; psoralens, and ultraviolet A (PUVA) |
| 96920 | Excimer Laser treatment for (psoriasis); total area less than 250 sq cm |
| 96921 | Excimer Laser treatment for (psoriasis); Total area 250-500 sq cm |
| 96922 | Excimer Laser treatment for (psoriasis); Total area over 500 sq cm |
| E0691 | Ultraviolet light therapy system, includes bulbs/lamps, timer and eye protection; treatment area 2 sq ft or less |
| E0692 | Ultraviolet light therapy system panel, includes bulbs/lamps, timer and eye protection, 4 ft panel |
| E0693 | Ultraviolet light therapy system panel, includes bulbs/lamps, timer and eye protection, 6 ft panel |
| E0694 | Ultraviolet multidirectional light therapy system in 6 ft cabinet, includes bulbs/lamps, timer, and eye protection |
| J8999 | Prescription drug, oral, chemotherapeutic, not otherwise specified |
Background
Targeted phototherapy (for example, excimer laser or localized NB-UVB) delivers localized ultraviolet treatment to affected lesions with the intent of avoiding whole-body UV exposure and thereby limiting carcinogenic risk associated with treating limited areas of disease.
Revision History
Policy added to the BCBSKS website (posted 08-29-2014; effective 09-28-2014).
Added HCPCS device codes E0691, E0692, E0693, and E0694 to the Coding section (correction applied 05-28-2015).
Policy language updated to state that home phototherapy using UVA light devices is considered experimental/investigational in the Policy section.
Policy republished effective 10-01-2015 for ICD-10 implementation (published 11-10-2015) with addition of ICD-10 code L20.9 in the Coding section.
Description section updated.
Updated Description, Rationale, and References sections.
Updated Description and Rationale sections; Coding section updated.
Updated References and Rationale sections (05-23-2021).
Multiple policy updates including changes to UVA phototherapy medical necessity language, adjustment of guideline thresholds (eg, replaced 5% with 3%), addition of clinical clarifications (items added to policy items), and associated Coding and Rationale updates.
Policy last reviewed on 12-12-2023 (document last_review date).
| Note | Effective date / history |
|---|---|
| Follow current policy for treatment sequencing: Policy history notes changes to medically necessary statements and criteria (e.g., limits and indications updated over time); providers should follow current policy criteria for stepwise treatment requirements. | Policy effective date: 2021-05-23; last review: 2023-12-12. Revision history highlights: policy added 09-28-2014; multiple subsequent revisions including coding updates (01-08-2015), ICD-10 updates (10-01-2015), and policy section updates (06-15-2022). |
| Providers should follow the current Policy for sequencing of topical therapies, NB-UVB, targeted phototherapy, and PUVA; prior authorization and coverage determinations depend on meeting the Policy section requirements and member contract provisions. | No review or update is scheduled; contact Blue Cross and Blue Shield of Kansas customer service or professional/institutional relations for questions about coverage. |
The policy record shows a revision history entry noting the document was archived on 12-12-2023. Contact Blue Cross and Blue Shield of Kansas for current status and questions about coverage.
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