Four Tier Drug Plan (Formulary) — Coverage Criteria
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This document governs the prescription drug list (formulary) for Anthem members, describing covered drugs, tier placement, restrictions (e.g., prior authorization, step therapy, quantity limits), and member resources; it affects members and providers using Anthem pharmacy benefits.
No material clinical or coverage changes in this revision.
Coverage Criteria and Formulary Scope
Some drugs listed on the formulary may not be covered for a particular member depending on the member's specific plan design and benefit exclusions. Members and providers should consult the member's Certificate/Evidence of Coverage or Summary Plan Description for plan‑level limitations and exclusions that determine actual coverage.
The document excerpt is primarily a formulary drug listing that assigns medications to tiers (Tier 1 through Tier 4) and annotates entries with plan-level flags (for example, PA, QL, SP). This portion does not present standalone medical‑necessity criteria; instead, tier placement and notes indicate preferred status and any utilization management that may apply.
In the provided segment there are no explicit clinical exclusion rules stated; the lines focus on formulation‑specific tier assignments, equivalence mappings, and Notes annotations (for example, PA or QL) rather than prescriptive clinical exclusion criteria.
Provider Actions — Authorization, Step Therapy, Documentation
Prior Authorization Required
Certain drugs on the formulary require prior authorization (PA) before benefits will be approved. If PA is not obtained, claims may be denied. This applies across multiple classes including specialty, injectable, high‑tier, oncology, and selected oral agents.
- Examples include specialty agents (e.g., OTEZLA XR, ORENCIA, ENBREL) and many biologics/injectables (PA; LD; QL; SP noted).
- Antineoplastic agents (oral and IV) commonly carry PA, LD, QL and/or SP flags (e.g., LYNPARZA, RUBRACA, TALZENNA, ZEJULA).
- High‑tier specialty products (e.g., DIACOMIT, EPIDIOLEX, FINTEPLA, TEZSPIRE) are noted with PA; LD; QL; SP.
Prior Authorization and Utilization Management for Stimulants
Stimulant products and other selected ADHD agents are frequently subject to PA, quantity limits (QL), dose optimization (DO), and sometimes step therapy (ST). Prescribers should obtain PA when Notes indicate PA or ST to avoid denial.
- Examples: amphetamine/dextroamphetamine formulations, methylphenidate ER products, lisdexamfetamine — many formulations show Notes = PA; QL; DO or ST.
- Utilization management for stimulants may include diagnosis requirements, QL limits, and ST pathways for certain formulations (chewable/transdermal forms often flagged ST).
Prior Authorization on Specialty / High‑Tier Products
Specialty, injectable, and select Tier 3–4 agents frequently require PA and may also be limited distribution (LD), have quantity limits (QL), and require specialty pharmacy (SP) dispensing. These flags together can affect coverage, fulfillment, and timing of therapy.
- Examples: FASENRA, NUCALA, TEZSPIRE, OTEZLA XR — Notes = PA; LD; QL; SP.
- Incretin mimetics and GLP‑1 agents (MOUNJARO, OZEMPIC, TRULICITY) are noted PA; QL and may follow specialty or step pathways.
- Pulmonary hypertension and certain cardiac agents (e.g., CAMZYOS, ambrisentan, bosentan, OPSUMIT, UPTRAVI) include PA; LD; QL; SP flags.
Prior Authorization for Specific IV/Formulated Products
Some IV/infusion and reconstituted formulations have specific PA requirements (and may be limited distribution). Verify product formulation notes (e.g., reconstituted cefazolin solutions) before ordering or billing to ensure authorization and appropriate dispensing channel.
- Examples: multiple cefazolin sodium reconstituted/dextrose IV solutions are listed; specific reconstituted/packaged IV cefazolin entries may carry PA or special handling.
- Many oncology IV agents and reconstituted injectables are annotated SP and/or LD — plan prior authorization and specialty dispensing rules apply.
Authorization Flags and Utilization Management Triggers
Utilization management flags (PA, ST, QL, LD, SP, AL, DO) are present throughout the drug list and can trigger coverage denials or changes in fulfillment. When any of these flags appear in the Notes column, follow the plan’s utilization and dispensing requirements.
- PA = prior authorization; ST = step therapy; QL = quantity limits; LD = limited distribution; SP = specialty pharmacy; AL = age limits; DO = dose optimization; BE = benefit exclusion.
- Entries with PA/LD/QL/SP require administrative follow‑up — obtain prior authorization, document clinical rationale, and coordinate with specialty/limited distributors as needed.
- PA/LD/QL/SP flags increase risk of denial if requirements are not met.
Required Documentation for Authorization Requests
Providers must submit required documentation with PA/QL/LD/SP requests. Documentation supports medical necessity, prior treatment attempts (for ST), dosing justification (DO), age or diagnosis criteria (AL), and supply/distribution needs for LD/SP products.
- Provide clinical notes, prior therapy history, relevant labs or diagnostic records, and prescriber rationale when requesting PA.
- Quantity limit (QL) requests should include proposed duration and total supply justification.
- For limited distribution (LD) or specialty pharmacy (SP) products, include preferred or required dispensing pharmacy and any enrollment forms the manufacturer requires.
How to Request Prior Authorization
How to request prior authorization: prescribers can call the Member Services number on the member’s ID card or submit a prior authorization form via the Anthem website. Initiate PA before dispensing when a Notes entry indicates PA, ST, LD, or SP to avoid denials.
- Call Member Services or download and submit the PA form from the payer website.
- Start PA early for limited distribution or specialty drugs to allow time for coordination with the distributing pharmacy.
Step Therapy and Therapeutic Equivalence Guidance
Step therapy (ST) and therapeutic substitution guidance appear on multiple entries. When Notes indicate ST or show equivalence mappings (’=’), the plan may require trial of preferred/step agents before approving higher‑tier or nonpreferred drugs.
- ST flags appear for some antipsychotics, antidiabetics, and stimulant/transdermal formulations. Follow required step pathways before requesting PA for later‑line agents.
- ’=’ mappings in the list suggest therapeutic equivalence or preferred alternatives that should be tried per step therapy rules.
Abbreviations and Formulary Definitions
Step Therapy Rules and Affected Products
| Coverage note | Interpretation |
|---|---|
| ST or DO flag present on drug line (example: multiple amphetamine/dextroamphetamine entries) | |
| Presence of ST (step therapy) or DO (diagnosis override/dose optimization) in the Notes column indicates a step therapy or dose‑optimization requirement must be met before coverage is approved |
| Product / formulation | Notes (as listed) |
|---|---|
| methylphenidate hcl oral tablet chewable 2.5 mg / 5 mg / 10 mg | |
| Notes = ST; DO (for 2.5 mg: ST; DO shown) and PA; QL or PA; LD; QL for other chewable strengths as listed | |
| methylphenidate transdermal patch 10 mg/9hr, 15 mg/9hr, 20 mg/9hr, 30 mg/9hr | |
| Notes = ST; DO for 10/15 mg; ST; QL for 20/30 mg as shown in the formulary lines |
| Analgesic / related product | Notes indicating ST |
|---|---|
| Select nonnarcotic analgesic entries (example block shows analgesics with Notes) | |
| Notes include 'ST; QL' on specific analgesic lines indicating step therapy plus quantity limits may apply before coverage | |
| APLENZIN (antidepressant listed under misc antidepressants but referenced in analytic context) | |
| Notes = ST; DO or ST; QL for some strengths (APLNEZIN shown with ST; DO and ST; QL on higher strengths) as listed |
| Flag | Implication |
|---|---|
| SP (specialty) noted on multiple biologic/high‑tier lines (e.g., FASENRA, NUCALA, TEZSPIRE) | |
| SP indicates specialty pharmacy handling/distribution; explicit step sequences are not shown in the excerpt but specialty management pathways apply |
| Annotation | Possible implication |
|---|---|
| Entries annotated with SP and/or PA (e.g., TEZSPIRE Notes = PA; LD; QL; SP) | |
| These high‑tier/specialty annotations suggest utilization controls such as prior authorization, limited distribution, and specialty dispensing may apply though exact step rules are not provided in excerpt |
| Example product | ST noted? |
|---|---|
| APLENZIN oral tablet extended release 174 mg / 348 mg / 522 mg | |
| Notes = ST; DO (174 mg) and ST; QL (higher strengths) — ST applies where noted | |
| TRIJARDY XR oral tablet extended release 24 hour | |
| Notes = ST; QL indicating step therapy applies for TRIJARDY XR as listed |
| Annotation | Example / Interpretation |
|---|---|
| AL noted on product line (example: KOMZIFTI oral capsule Notes = AL; QL) | |
| 'AL' is used on some entries to indicate alternative/age/alignments or alternative/step edits — implying substitution or alternative therapy edits may apply (KOMZIFTI listed with AL; QL) |
| Agent / line | ST present? |
|---|---|
| FANAPT oral tablet and titration packs | |
| Notes include ST; DO or ST; QL on multiple FANAPT lines indicating step therapy applies | |
| Several antipsychotic and related agents (paliperidone, risperidone class lines) | |
| Notes include AL; QL or ST on some antipsychotic lines — some agents include 'ST' indicating step therapy applies |
| Product | Notes (ST examples) |
|---|---|
| ABILIFY MYCITE maintenance and starter kit therapy packs | |
| Notes = ST; DO (maintenance) and ST; QL (20 mg) — ST flagged on ABILIFY MYCITE entries | |
| SECUADO (transdermal patch) / thiothixene entries in antipsychotic group | |
| Notes include ST on specific entries (SECUADO and certain thiothixene lines show ST or AL/QL as applicable) indicating step edits before coverage |
| Specialty / high‑tier examples | Utilization controls noted |
|---|---|
| FASENRA, NUCALA, CINQAIR, other biologic injectables | |
| Notes = PA; LD; QL; SP — prior authorization required and distribution may be limited to specialty channels | |
| DIACOMIT, EPIDIOLEX, FINTEPLA and other anticonvulsant specialty agents | |
| Notes = PA; LD; QL; SP where listed — specialty agents require PA and may be limited to LD/SP channels |
| Therapeutic group / example | Tiering / equivalence note |
|---|---|
| Oral contraceptives (multiple combination oral contraceptive entries) | |
| Many oral contraceptives mapped to Tier 1 / 1a / 1b (preferred) as shown in the contraceptive listings and equivalence mappings | |
| Selected IV antibiotics / cephalosporins (cefazolin, cefepime, FETROJA) | |
| Listed at higher cost tiers (cefazolin and cephalosporin IV solutions shown Tier = 3) with '=' mappings indicating therapeutic equivalence/substitution guidance |
Quantity Limits and Affected Products
Dispensing and Administration Site Notes
LD/SP indicate restricted distribution or specialty handling
LD or SP annotations indicate the medication may be dispensed only through specialty pharmacies or limited distributors; infusion center, specialty pharmacy, or office administration may be required depending on the product.
Some PA/LD drugs require specialty/infusion/office site‑of‑care
Certain PA/LD drugs (examples in the list: SPRAVATO, ZTALMY, TZIELD, mifepristone) may require specialty pharmacy, infusion center, or office administration; follow product‑specific site‑of‑care guidance.
Coordinate specialty pharmacy dispensing for SP/LD products
Many agents designated SP or LD imply specialty pharmacy dispensing; coordinate with the plan's specialty pharmacy channel and document fulfillment arrangements when requesting coverage.
Follow site‑of‑care and dispensing rules for LD/SP products
Injectables and specialty products annotated LD or SP (e.g., oncology agents, biologics) imply specific site‑of‑care or dispensing channels (infusion center or specialty pharmacy); follow distribution and administration rules in PA/fulfillment.
Background and Formulary Overview
The formulary groups medications into therapeutic classes and assigns them to tiers based on clinical value, availability of OTC or generic alternatives, safety, and cost. A Pharmacy & Therapeutics (P&T) committee reviews and maintains the drug list, which informs tier placement and formulary decisions.
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