ICD-10-CM Code For Hormone Sensitivity Malignancy Status: Group Overview

The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group Z19 includes diagnoses indicating a history of or current malignancy that is hormone sensitive, such as endocrine-responsive breast and prostate cancers, and other tumors influenced by hormonal status. These ICD-10-CM diagnosis codes are used to document oncologic status relevant to hormone receptor sensitivity, capturing clinical history, treatment implications, and surveillance needs. Accurate coding within the ICD-10-CM Z19 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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ICD-10-CM Z19: Hormone Sensitivity Malignancy Status Overview

This group represents diagnoses indicating a history or presence of malignancy that is sensitive to hormonal factors, commonly involving breast and prostate tissues and endocrine-responsive tumors. These codes target oncologic status related to hormone receptor or endocrine responsiveness and are important for care planning and surveillance. Accurate coding matters for complete clinical records and supports appropriate reimbursement for services tied to cancer management and follow-up.

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ICD-10-CM Code For Hormone Sensitivity Malignancy Status: Group Overview

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ICD-10-CM Z19: Hormone Sensitivity Malignancy Status Overview

When to Use

Use a code from this group when documenting a patient with a known hormone-sensitive malignancy or a history of such malignancy that affects management. Select these codes to reflect hormone receptor–related status for care planning, surveillance, or coordination of oncology services.

ICD-10-CM Codes

2 rows

ICD-10-CM Code	Description
Z19.1	Hormone sensitive malignancy status
Z19.2	Hormone resistant malignancy status

DRG Codes

1 rows

DRG Code	Description
951	Other Factors Influencing Health Status

Typical Clinical Scenarios

A 62-year-old woman with a history of estrogen receptor–positive breast cancer treated with lumpectomy and adjuvant therapy presents for routine oncology follow-up to discuss ongoing endocrine therapy. She is clinically stable on aromatase inhibitor therapy and the visit documents her known hormone-sensitive tumor status to guide surveillance and treatment planning; a hormone sensitivity malignancy status code is recorded to denote the tumor’s receptor-driven behavior. Typical codes: Z19.1
A 48-year-old premenopausal woman is admitted to the emergency department with acute vaginal bleeding and pelvic pain; workup reveals metastatic endometrial carcinoma that is progesterone receptor–positive influencing systemic therapy options. During hospitalization the care team documents the malignancy’s hormone receptor positivity as part of staging and treatment decision-making, and assigns a hormone sensitivity status code to capture the receptor-driven nature of the tumor. Typical codes: Z19.2
A male patient with long-standing prostate cancer presents to a multidisciplinary clinic for consideration of changes to androgen-deprivation therapy after rising PSA; chart review notes confirmed androgen-sensitive disease at diagnosis which impacted past treatment choices. The clinic encounter documents the tumor’s hormone-sensitive status as relevant comorbidity affecting current management and prognosis, and a hormone sensitivity malignancy status code is used in the problem list. Typical codes: Z19.2

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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When to Use

ICD-10-CM Codes

2 rows

ICD-10-CM Code	Description
Z19.1	Hormone sensitive malignancy status
Z19.2	Hormone resistant malignancy status

DRG Codes

1 rows

DRG Code	Description
951	Other Factors Influencing Health Status

Typical Clinical Scenarios

A 62-year-old woman with a history of estrogen receptor–positive breast cancer treated with lumpectomy and adjuvant therapy presents for routine oncology follow-up to discuss ongoing endocrine therapy. She is clinically stable on aromatase inhibitor therapy and the visit documents her known hormone-sensitive tumor status to guide surveillance and treatment planning; a hormone sensitivity malignancy status code is recorded to denote the tumor’s receptor-driven behavior. Typical codes: Z19.1
A 48-year-old premenopausal woman is admitted to the emergency department with acute vaginal bleeding and pelvic pain; workup reveals metastatic endometrial carcinoma that is progesterone receptor–positive influencing systemic therapy options. During hospitalization the care team documents the malignancy’s hormone receptor positivity as part of staging and treatment decision-making, and assigns a hormone sensitivity status code to capture the receptor-driven nature of the tumor. Typical codes: Z19.2
A male patient with long-standing prostate cancer presents to a multidisciplinary clinic for consideration of changes to androgen-deprivation therapy after rising PSA; chart review notes confirmed androgen-sensitive disease at diagnosis which impacted past treatment choices. The clinic encounter documents the tumor’s hormone-sensitive status as relevant comorbidity affecting current management and prognosis, and a hormone sensitivity malignancy status code is used in the problem list. Typical codes: Z19.2

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

ICD-10-CM Code For Hormone Sensitivity Malignancy Status: Group Overview

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ICD-10-CM Z19: Hormone Sensitivity Malignancy Status Overview

ICD-10-CM Code For Hormone Sensitivity Malignancy Status: Group Overview

Sign up for ICD-10-CM Code For Hormone Sensitivity Malignancy Status: Group Overview policy alerts

ICD-10-CM Z19: Hormone Sensitivity Malignancy Status Overview

When to Use

ICD-10-CM Codes

DRG Codes

Typical Clinical Scenarios

Which diagnoses are included in the ICD-10-CM Z19 group for hormone sensitivity malignancy status?

When should a coder use `Z19.1` versus `Z19.2`?

How does documenting a Z19 code affect billing and reimbursement?

Which clinical scenarios are represented by the Z19 group?

Are Z19 codes linked to any DRGs relevant for analysts?

References

When to Use

ICD-10-CM Codes

DRG Codes

Typical Clinical Scenarios

Which diagnoses are included in the ICD-10-CM Z19 group for hormone sensitivity malignancy status?

When should a coder use `Z19.1` versus `Z19.2`?

How does documenting a Z19 code affect billing and reimbursement?

Which clinical scenarios are represented by the Z19 group?

Are Z19 codes linked to any DRGs relevant for analysts?

References