Summary & Overview
HCPCS S9375: Home Infusion Hydration Therapy, 1–2 Liters/Day
HCPCS Level II code S9375 designates a per diem charge for home infusion hydration therapy covering administrative services, professional pharmacy services, care coordination, and all necessary supplies and equipment when providing more than one liter but no more than two liters of hydration per day; drugs and nursing visits are billed separately. This code matters nationally as home-based infusion and hydration services expand to support care outside traditional facilities, affecting payer coverage, reimbursement pathways, and care coordination models.
Key payers referenced include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of the clinical service represented by the code, typical site-of-service implications, and what to expect in payer coverage discussions. The publication outlines common billing considerations and benchmarks, summarizes policy and coding updates that affect per diem home infusion services, and provides clinical context for appropriate use of the code.
The report is intended for billing professionals, pharmacy and home infusion program managers, and policy analysts seeking a national perspective on how S9375 is used, how payers approach coverage, and what operational and documentation elements commonly influence payment and utilization. Data not available in the input are noted where relevant.
Billing Code Overview
HCPCS Level II code S9375 represents home infusion therapy for hydration, billed as a per diem for administrative and professional pharmacy services, care coordination, and all necessary supplies and equipment when delivering more than one liter but no more than two liters per day. Drugs and nursing visits are coded separately.
Service type: Home infusion hydration therapy, per diem administrative and professional services
Typical site of service: Patient's home (home health/home infusion setting)
Clinical & Coding Specifications
Clinical Context
A typical patient is an adult receiving home hydration infusion for symptomatic volume depletion or for adjunctive hydration during outpatient chemotherapy. For example, a 68-year-old patient with nausea, vomiting, and poor oral intake related to cancer therapy is discharged home with a peripherally inserted catheter and a daily ordered hydration infusion of 1.5 liters. The home infusion pharmacy coordinates pharmacy professional services, administrative oversight, equipment and supply delivery, scheduling of nursing visits, and documentation of daily per diem hydration services while the actual intravenous fluids and nursing visits are billed separately.
Workflow: The ordering clinician documents the diagnosis and orders home hydration specifying volume (more than 1 L up to 2 L/day). The home infusion provider performs clinical assessment, obtains insurance authorizations, delivers supplies and infusion pump, and schedules nursing visits for catheter maintenance and infusion start/stop. Nursing documents infusion tolerance and any complications; the pharmacy prepares or dispenses fluids and communicates with the prescriber for changes. Billing uses the per diem HCPCS Level II code S9375 for administrative and professional pharmacy services, with separate line items for drug/fluid supplies and nursing visits as appropriate.
Coding Specifications
| Modifier | Description | When to Use |
|---|---|---|
59 | Distinct procedural service |