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    v1.0.28
    OpenPayerBilling CodesTemporary National Codes (Non-Medicare)HCPCS hcpcs-s8301-infection-control-supplies-unspecified
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    HCPCS Level II S8301: Infection Control Supplies, Not Otherwise Specified

    HCPCS Level II code S8301 describes infection control supplies, not otherwise specified, representing supply items used for infection prevention and control; service type: medical supply provision, typical site of service: outpatient clinics, home health settings, and other ambulatory care environments where consumable infection control products are furnished to patients or caregivers.

    For related coverage guidance, see recent payer policy updates: Fixed Wing Air Ambulance Transport, Air Ambulance, Ambulance Services (for Tennessee Only).

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A patient receiving infection control supplies typically presents in an outpatient or home-care setting where supplies are required to prevent or limit healthcare-associated infections. Example scenario: an adult with a chronic wound managed by a home health nurse requires periodic delivery of single-use infection control supplies such as sterile gloves, antimicrobial wound dressings, disinfectant wipes, and sharps containers. The clinical workflow: clinician assesses wound care needs, orders necessary supplies, documents medical necessity in the patient record, submits claim for S8301 with appropriate diagnosis codes and modifiers, and arranges delivery or dispensation to the patient at the clinic or home. Typical sites of service include outpatient clinics, ambulatory wound care centers, long-term care facilities, and patient homes. Common documentation includes the itemized list of supplies, frequency of use, clinical indication (e.g., chronic non-healing wound), and provider or agency taxonomy under which the supplies are billed.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    97597Debridement; selective debridement, without anesthesia, open wound, including topical application(s), wound assessment, and instruction(s) for ongoing care, first 20 sq cm or lessOften performed alongside infection control supplies when wound care requires removal of devitalized tissue and subsequent dressing changes using S8301 supplies
    11042Debridement, subcutaneous tissue (eg, undermining, including epidermis, dermis, and subcutaneous tissue)Surgical debridement generates need for sterile infection control supplies billed with S8301 for peri-procedural infection prevention
    99503Home visit for removal and disposal of sutures or staplesHome health visits that include supply use such as sterile gloves, dressings, and sharps containers covered under S8301
    99213Office or other outpatient visit for the evaluation and management of an established patient, low to moderate complexityClinical visits that include ordering or dispensing infection control supplies; documentation supports billing of S8301
    96372Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscularWhen infection control supplies are used for injections administered in the outpatient or home setting, supplies may be billed using S8301 alongside the injection CPT

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    54Modifier ‑54 (“Surgical care only”) is appended to a CPT surgical procedure when the reporting surgeon performs the intraoperative (surgical) component but does not furnish the preoperative and/or…- Use modifier -54 when the reporting surgeon provided only the intraoperative (surgical) component of a procedure and preoperative and/or postoperative management has been or will be provided by…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    56Modifier ‑56 indicates the reporting provider furnished only the preoperative management for a surgical procedure and did not perform the intraoperative or postoperative care. It is used in…- Use Modifier -56 when a provider performs only the preoperative management in a split‑care situation (one physician manages preop care while a different physician performs the intraoperative…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    363L00000XNurse Practitioner(1) A registered nurse provider with a graduate degree in nursing prepared for advanced practice involving independent and interdependent decision mak…
    367500000XCertified Registered Nurse Anesthetist(1) A licensed registered nurse with advanced specialty education in anesthesia who, in collaboration with appropriate health care professionals, prov…
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    208000000XPediatrics PhysicianA pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
    2278P4000XPatient Transport Certified Respiratory TherapistTransport respiratory therapist provide patient assessment, initiation of treatment modalities and continued monitoring of patient status of the criti…
    2086S0127XTrauma Surgery PhysicianTrauma surgery is a recognized subspecialty of general surgery. Trauma surgeons are physicians who have completed a five-year general surgery residenc…
    156FX1100XOphthalmic Technician/TechnologistAn ophthalmic technician/technologist assists ophthalmologists by performing ophthalmic clinical functions, including administering eye exams, adminis…
    1223P0300XPeriodonticsThat specialty of dentistry which encompasses the prevention, diagnosis and treatment of diseases of the supporting and surrounding tissues of the tee…

    Related ICD-10-CM Codes

    26 rows

    ICD-10-CM CodeDescription
    A02.1Salmonella sepsis
    A41.9Sepsis, unspecified organism
    A49.9Bacterial infection, unspecified
    A54.89Other gonococcal infections
    A90Dengue fever [classical dengue]
    B34.9Viral infection, unspecified
    B95.61Methicillin susceptible Staphylococcus aureus infection as the cause of diseases classified elsewhere
    E11.65Type 2 diabetes mellitus with hyperglycemia
    H66.91Otitis media, unspecified, right ear
    J15.9Unspecified bacterial pneumonia

    Showing 1–10 of 26

    Related Payer Policy Updates

    Specialty: Emergency & Medical Transportation1 / 3

    9 rows

    PolicyPayerEffective Date
    Fixed Wing Air Ambulance TransportCigna2026-08-15
    Air AmbulanceAmbetter Georgia2026-08-01
    Ambulance Services (for Tennessee Only)UnitedHealthcare2026-08-01
    Ambulance Services (for New Mexico Only)UnitedHealthcare2026-08-01
    Clinical Policy: Air AmbulanceArizona Complete Health2026-08-01
    Clinical Policy: Air AmbulanceCentene2026-08-01
    Air AmbulanceCentene2026-08-01
    Clinical Policy: Air AmbulanceAmbetter Nevada2026-08-01
    Ambulance TransportProvidence Health Plan2026-07-01

    Related Codes

    HCPCS-LEVEL-II-S2152-SOLID-ORGAN-TRANSPLANTATION-GLOBAL-CARE

    HCPCS Level II S2152: Solid Organ Procurement and Transplantation

    HCPCS-LEVEL-II-S2266-INDUCED-ABORTION-29-TO-31-WEEKS

    HCPCS Level II S2266: Induced Abortion, 29 to 31 Weeks

    HCPCS-LEVEL-II-S3630-EOSINOPHIL-COUNT-BLOOD-DIRECT

    HCPCS Level II S3630: Eosinophil Count, Blood, Direct

    HCPCS-LEVEL-II-S4017-INCOMPLETE-ART-CYCLE-CANCELLED-PRIOR-TO-STIMULATION

    HCPCS Level II S4017: Incomplete Cycle — Cancelled Prior to Stimulation

    HCPCS-LEVEL-II-S8055-ULTRASOUND-GUIDANCE-MULTIFETAL-REDUCTION-TC

    HCPCS Level II S8055: Ultrasound Guidance for Multifetal Pregnancy Reduction

    HCPCS-LEVEL-II-S8940-EQUESTRIAN-HIPPOTHERAPY-PER-SESSION

    HCPCS Level II S8940: Equestrian/Hippotherapy, Per Session

    HCPCS-LEVEL-II-S9024-PARANASAL-SINUS-ULTRASOUND

    HCPCS Level II S9024: Paranasal Sinus Ultrasound

    HCPCS-LEVEL-II-S9366-HOME-TPN-1-2L-PER-DAY-HOME-INFUSION

    HCPCS Level II S9366: Home Infusion TPN, 1–2 L/day

    HCPCS-LEVEL-II-S9446-GROUP-PATIENT-EDUCATION-NON-PHYSICIAN

    HCPCS S9446: Patient Education, Non-Physician Provider, Group, Per Session

    HCPCS-LEVEL-II-S9451-EXERCISE-CLASS-NON-PHYSICIAN-SESSION

    HCPCS S9451: Exercise Classes, Non-Physician Provider, Per Session

    Showing 1–10 of 532

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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