HCPCS Q4148: Neox/Clarix Cord Biologic Product per Sq Cm

Medicare pays $133 on average nationally for this procedure.

HCPCS Level II code Q4148 describes the billing descriptor for biologic cord products (Neox cord 1k, Neox cord RT, or Clarix cord 1k) billed per square centimeter as an add-on, list separately in addition to primary procedure, representing a biologic graft/placental-derived cord product used in procedures that apply regenerative or wound-healing material; the service type is a biologic graft application and the typical site of service is operative or procedural settings (hospital outpatient surgery, ambulatory surgery center, or operating room) where the primary procedure requiring the cord product is performed.

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HCPCS Q4148: Neox/Clarix Cord Biologic Product per Sq Cm

Medicare pays $133 on average nationally for this procedure.

Customize your policy alerts

Sign up for hcpcs Q4148 policy alerts

Get alerted when payer policies referencing Q4148 are released or updated.

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Receive email alerts as soon as relevant payer policies are published or updated.

Clinical & Coding Specifications

Clinical Context

A typical patient is a 45–70-year-old adult presenting to an outpatient wound care clinic or an ambulatory surgical center with a chronic, nonhealing soft-tissue wound (for example, a diabetic foot ulcer, venous stasis ulcer, or complex surgical wound dehiscence) that has failed conservative management. The treating clinician (often a wound care specialist, plastic surgeon, or podiatrist) evaluates the wound, confirms adequate vascular supply or optimizes perfusion, performs debridement of necrotic tissue, and determines that an advanced biologic graft derived from umbilical cord matrix (e.g., Neox Cord 1K, Neox Cord RT, Clarix Cord 1K) is indicated to promote healing.

The product represented by Q4148 is billed as an add-on charge per square centimeter of graft placed. Typical workflow: wound assessment and measurement, sharp or surgical debridement, hemostasis, irrigation, application of the cord-derived graft sized to the wound bed, securement and dressings, and post-procedure dressing changes and follow-up visits. The service is commonly provided in outpatient wound centers, ambulatory surgery centers, hospital outpatient departments, or specialty clinics capable of performing minor outpatient procedures and biologic graft application. Patient education about immobilization, offloading (for plantar foot wounds), and infection signs is provided, with scheduled follow-up for graft take assessment and dressing changes.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`11042`	Debridement, subcutaneous tissue (first 20 sq cm or less)	Often performed immediately prior to graft placement to prepare the wound bed; larger debridement codes may apply depending on area.
`97597`	Debridement (eg, high-pressure lavage) open wound, selective debridement, without anesthesia; first 20 sq cm	Frequently used in outpatient settings for debridement before biologic grafting when appropriate.
`15271`	Application of skin substitute graft to trunk, arms, legs; first 100 sq cm or less, single layer	Represents related skin substitute application codes—used in some workflows when documenting graft application or alternative biologic products.
`15777`	Dermal substitute graft, or application of skin substitute for wounds, first 100 sq cm or less	Used when a dermal substitute is applied; documents placement of biologic or engineered graft material in conjunction with wound repair.
`99024`	Postoperative follow-up visit, global period, related to procedure	Used to document routine postoperative follow-up visits assessing graft take and wound healing.

Related Modifiers

8 rows

Modifier	Description	When to Use
22	Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…	- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
53	Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…	- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
73	Modifier 73 indicates a facility-level outpatient hospital or ASC procedure that was discontinued after the patient was prepared and taken to the procedure/operating room but before any anesthesia…	- When to use: Apply CPT modifier 73 on the FACILITY (outpatient hospital or ASC) claim when the patient has been fully prepared and physically taken into the procedure/operating room but the…
78	CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…	- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
80	CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…	- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
82	Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…	- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207L00000X	Anesthesiology Physician	An anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
207W00000X	Ophthalmology Physician	An ophthalmologist has the knowledge and professional skills needed to provide comprehensive eye and vision care. Ophthalmologists are medically train…
208800000X	Urology Physician	A urologist manages benign and malignant medical and surgical disorders of the genitourinary system and the adrenal gland. This specialist has compreh…
363A00000X	Physician Assistant	A physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
163WX0601X	Otorhinolaryngology & Head-Neck Registered Nurse	Nursing Service Providers · Registered Nurse
133VN1101X	Gerontological Nutrition Registered Dietitian	An individual who is a Specialist in Gerontological Nutrition and provides nutrition care to promote quality of life and optimal health for older adul…
286500000X	Military Hospital	A health care facility operated by the Department of Defense.
163WI0500X	Infusion Therapy Registered Nurse	Nursing Service Providers · Registered Nurse

Related ICD-10-CM Codes

29 rows

ICD-10-CM Code	Description
E10.22	Type 1 diabetes mellitus with diabetic chronic kidney disease
E10.65	Type 1 diabetes mellitus with hyperglycemia
E11.21	Type 2 diabetes mellitus with diabetic nephropathy
E11.22	Type 2 diabetes mellitus with diabetic chronic kidney disease
E11.65	Type 2 diabetes mellitus with hyperglycemia
I12.9	Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease
I13.0	Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease
I13.11	Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease
N17.9	Acute kidney failure, unspecified
N18.1	Chronic kidney disease, stage 1

Showing 1–10 of 29

HCPCS Q4139: Amniomatrix or Biodmatrix, Injectable, 1 cc

HCPCS-LEVEL-II-Q4256-AREA-BASED-PROCEDURAL-ADD-ON-PER-SQ-CM

HCPCS Q4256: MLG-complete Skin Graft Material, Per Sq Cm

HCPCS-LEVEL-II-Q5132-ADALIMUMAB-AFZB-ABRILADA-10MG-INJECTION

HCPCS Level II Q5132: Injection, adalimumab-afzb (Abrilada), 10 mg

HCPCS-Q0035-CARDIOKYMOGRAPHY-CARDIAC-MOTION-RECORDING

HCPCS Level II Q0035: Cardiokymography

HCPCS-Q0081-INFUSION-THERAPY-NON-CHEMOTHERAPEUTIC-PER-VISIT

HCPCS Level II Q0081: Infusion Therapy, Non‑Chemotherapeutic, Per Visit

HCPCS-Q0083-CHEMOTHERAPY-NON-INFUSION-ADMINISTRATION

HCPCS Q0083: Chemotherapy Administration, Non-Infusion Methods

HCPCS-Q0084-CHEMOTHERAPY-INFUSION-ADMINISTRATION-PER-VISIT

HCPCS Q0084: Chemotherapy Infusion Administration, Per Visit

HCPCS-Q0085-CHEMOTHERAPY-INFUSION-PLUS-OTHER-TECHNIQUES-PER-VISIT

HCPCS Q0085: Chemotherapy Infusion Plus Other Technique(s), Per Visit

HCPCS-Q0091-PAP-SMEAR-SPECIMEN-COLLECTION-TRANSPORT

HCPCS Q0091: Screening Papanicolaou Smear Collection and Transport

HCPCS-Q0092-PORTABLE-XRAY-EQUIPMENT-SETUP

HCPCS Q0092: Set-up Portable X-ray Equipment

Showing 1–10 of 629

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Clinical & Coding Specifications

Clinical Context

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`11042`	Debridement, subcutaneous tissue (first 20 sq cm or less)	Often performed immediately prior to graft placement to prepare the wound bed; larger debridement codes may apply depending on area.
`97597`	Debridement (eg, high-pressure lavage) open wound, selective debridement, without anesthesia; first 20 sq cm	Frequently used in outpatient settings for debridement before biologic grafting when appropriate.
`15271`	Application of skin substitute graft to trunk, arms, legs; first 100 sq cm or less, single layer	Represents related skin substitute application codes—used in some workflows when documenting graft application or alternative biologic products.
`15777`	Dermal substitute graft, or application of skin substitute for wounds, first 100 sq cm or less	Used when a dermal substitute is applied; documents placement of biologic or engineered graft material in conjunction with wound repair.
`99024`	Postoperative follow-up visit, global period, related to procedure	Used to document routine postoperative follow-up visits assessing graft take and wound healing.

Related Modifiers

8 rows

Modifier	Description	When to Use
22	Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…	- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
53	Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…	- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
73	Modifier 73 indicates a facility-level outpatient hospital or ASC procedure that was discontinued after the patient was prepared and taken to the procedure/operating room but before any anesthesia…	- When to use: Apply CPT modifier 73 on the FACILITY (outpatient hospital or ASC) claim when the patient has been fully prepared and physically taken into the procedure/operating room but the…
78	CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…	- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
80	CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…	- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
82	Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…	- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207L00000X	Anesthesiology Physician	An anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
207W00000X	Ophthalmology Physician	An ophthalmologist has the knowledge and professional skills needed to provide comprehensive eye and vision care. Ophthalmologists are medically train…
208800000X	Urology Physician	A urologist manages benign and malignant medical and surgical disorders of the genitourinary system and the adrenal gland. This specialist has compreh…
363A00000X	Physician Assistant	A physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
163WX0601X	Otorhinolaryngology & Head-Neck Registered Nurse	Nursing Service Providers · Registered Nurse
133VN1101X	Gerontological Nutrition Registered Dietitian	An individual who is a Specialist in Gerontological Nutrition and provides nutrition care to promote quality of life and optimal health for older adul…
286500000X	Military Hospital	A health care facility operated by the Department of Defense.
163WI0500X	Infusion Therapy Registered Nurse	Nursing Service Providers · Registered Nurse

Related ICD-10-CM Codes

29 rows

ICD-10-CM Code	Description
E10.22	Type 1 diabetes mellitus with diabetic chronic kidney disease
E10.65	Type 1 diabetes mellitus with hyperglycemia
E11.21	Type 2 diabetes mellitus with diabetic nephropathy
E11.22	Type 2 diabetes mellitus with diabetic chronic kidney disease
E11.65	Type 2 diabetes mellitus with hyperglycemia
I12.9	Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease
I13.0	Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease
I13.11	Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease
N17.9	Acute kidney failure, unspecified
N18.1	Chronic kidney disease, stage 1

Showing 1–10 of 29

HCPCS Q4139: Amniomatrix or Biodmatrix, Injectable, 1 cc

HCPCS-LEVEL-II-Q4256-AREA-BASED-PROCEDURAL-ADD-ON-PER-SQ-CM

HCPCS Q4256: MLG-complete Skin Graft Material, Per Sq Cm

HCPCS-LEVEL-II-Q5132-ADALIMUMAB-AFZB-ABRILADA-10MG-INJECTION

HCPCS Level II Q5132: Injection, adalimumab-afzb (Abrilada), 10 mg

HCPCS-Q0035-CARDIOKYMOGRAPHY-CARDIAC-MOTION-RECORDING

HCPCS Level II Q0035: Cardiokymography

HCPCS-Q0081-INFUSION-THERAPY-NON-CHEMOTHERAPEUTIC-PER-VISIT

HCPCS Level II Q0081: Infusion Therapy, Non‑Chemotherapeutic, Per Visit

HCPCS-Q0083-CHEMOTHERAPY-NON-INFUSION-ADMINISTRATION

HCPCS Q0083: Chemotherapy Administration, Non-Infusion Methods

HCPCS-Q0084-CHEMOTHERAPY-INFUSION-ADMINISTRATION-PER-VISIT

HCPCS Q0084: Chemotherapy Infusion Administration, Per Visit

HCPCS-Q0085-CHEMOTHERAPY-INFUSION-PLUS-OTHER-TECHNIQUES-PER-VISIT

HCPCS Q0085: Chemotherapy Infusion Plus Other Technique(s), Per Visit

HCPCS-Q0091-PAP-SMEAR-SPECIMEN-COLLECTION-TRANSPORT

HCPCS Q0091: Screening Papanicolaou Smear Collection and Transport

HCPCS-Q0092-PORTABLE-XRAY-EQUIPMENT-SETUP

HCPCS Q0092: Set-up Portable X-ray Equipment

Showing 1–10 of 629

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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HCPCS Q4148: Neox/Clarix Cord Biologic Product per Sq Cm

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HCPCS Q4148: Neox/Clarix Cord Biologic Product per Sq Cm

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Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

References

HCPCS Q4148: Neox/Clarix Cord Biologic Product per Sq Cm

Sign up for hcpcs Q4148 policy alerts

HCPCS Q4148: Neox/Clarix Cord Biologic Product per Sq Cm

Sign up for hcpcs Q4148 policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

What does HCPCS Q4148 represent and how is it billed?

In what clinical scenarios and settings is Q4148 commonly used?

Should Q4148 be billed alone or with other procedure codes?

Which modifiers are relevant when billing for procedures that include Q4148?

Which specialties typically use Q4148 and which payers commonly cover it?

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

What does HCPCS Q4148 represent and how is it billed?

In what clinical scenarios and settings is Q4148 commonly used?

Should Q4148 be billed alone or with other procedure codes?

Which modifiers are relevant when billing for procedures that include Q4148?

Which specialties typically use Q4148 and which payers commonly cover it?

References