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    v1.0.30
    OpenPayerBilling CodesTemporary CodesHCPCS hcpcs-q2041-axicabtagene-ciloleucel-car-t-cell-therapy
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    HCPCS Level II Q2041: Axicabtagene ciloleucel CAR T-cell Therapy

    HCPCS Level II code Q2041 represents axicabtagene ciloleucel, an autologous anti-CD19 CAR‑positive viable T‑cell therapy (up to 200 million cells) billed per therapeutic dose; the code includes leukapheresis and dose preparation procedures and reflects a cell therapy service typically delivered as an inpatient or specialized outpatient infusional/administration encounter at an academic medical center or certified cellular therapy program.

    For related coverage guidance, see recent payer policy updates: Truvada (Emtricitabine and Tenofovir Disoproxil Fumarate) for HIV Prevention and Treatment, HIV/AIDS Pharmacologic Prevention and Treatment, Long-Acting Injectable Antiretroviral Agents for HIV.

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    Clinical & Coding Specifications

    Clinical Context

    A 58-year-old patient with relapsed/refractory diffuse large B‑cell lymphoma (DLBCL) who has failed at least two prior lines of systemic therapy undergoes autologous CD19-directed CAR T-cell therapy using Q2041 (axicabtagene ciloleucel, up to 200 million viable CAR-positive autologous T cells). The clinical workflow includes: leukapheresis to collect peripheral blood mononuclear cells; cellular processing and manufacture of the CAR T product at a specialty cellular therapy laboratory; preconditioning lymphodepleting chemotherapy (typically fludarabine and cyclophosphamide) administered in the inpatient or outpatient oncology infusion setting; administration of a single therapeutic dose of Q2041 with close monitoring for infusion reactions, cytokine release syndrome (CRS), and immune effector cell–associated neurotoxicity syndrome (ICANS); and post-infusion observation with daily assessments, supportive care, and potential admission to an inpatient unit with intensive care capabilities if severe CRS or neurotoxicity occurs. Typical sites of service include an academic medical center or certified cellular therapy program with capabilities for leukapheresis, cell processing coordination, and inpatient/observational monitoring.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    38204Cellular therapy product harvesting for transplantation; bone marrow harvest only (if performed)Performed when bone marrow harvest is used instead of peripheral blood collection (infrequent for CAR T)
    36511Collection of peripheral blood stem cells for transplantation or for infusion (apheresis)Codes leukapheresis procedure used to collect T cells prior to manufacture of Q2041
    36514Therapeutic apheresis, unspecified; plasma exchange or leukapheresis (single volume)Alternate code used for leukapheresis sessions depending on payer rules and documentation
    96413Chemotherapy administration, intravenous infusion technique, up to 1 hour, single or initial substance/drugUsed for administration of lymphodepleting chemotherapy prior to CAR T infusion
    36415Collection of venous blood by venipuncturePre-procedure labs, type and screen, and other peripheral draws required in the peri-infusion period
    99223Initial hospital care, typically 70 minutes or moreInitial inpatient evaluation for a patient admitted for CAR T infusion and monitoring

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208000000X
    207P00000X
    2086S0102X
    3336C0002X
    363L00000X
    225XM0800X
    2278P1006X
    246ZC0007X

    Related ICD-10-CM Codes

    26 rows

    ICD-10-CM CodeDescription
    C83.30Diffuse large B-cell lymphoma, unspecified site
    C83.31Diffuse large B-cell lymphoma, lymph nodes of head, face, and neck
    C85.90Non-Hodgkin lymphoma, unspecified, unspecified site
    C85.99Non-Hodgkin lymphoma, unspecified, extranodal and solid organ sites
    C90.00Multiple myeloma not having achieved remission
    C90.02Multiple myeloma in relapse
    C91.00Acute lymphoblastic leukemia not having achieved remission
    C91.01Acute lymphoblastic leukemia, in remission
    C91.02Acute lymphoblastic leukemia, in relapse
    C91.10Chronic lymphocytic leukemia of B-cell type not having achieved remission

    Showing 1–10 of 26

    Related Payer Policy Updates

    Specialty: Infectious Disease1 / 3

    10 rows

    PolicyPayerEffective Date
    Truvada (Emtricitabine and Tenofovir Disoproxil Fumarate) for HIV Prevention and Treatmentpremerabluecrossofwashington2026-10-01
    HIV/AIDS Pharmacologic Prevention and Treatmentpremerabluecrossofwashington2026-10-01
    Long-Acting Injectable Antiretroviral Agents for HIVColorado Rocky Mountain Health Plans2026-10-01
    B-Hemolytic Streptococcus TestingOscar Health2026-10-01
    Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance AssaysOscar Health2026-10-01
    Hepatitis Testing (A, B, C, D) Coverage CriteriaOscar Health2026-10-01
    Pathogen Panel TestingOscar Health2026-10-01
    Lyme Disease Testing Coverage CriteriaOscar Health2026-10-01
    Diagnostic Testing of Common Sexually Transmitted InfectionsOscar Health2026-10-01
    Testing for Vector-Borne InfectionsOscar Health2026-10-01

    Related Codes

    HCPCS-LEVEL-II-Q4139-INJECTABLE-AMNIOMATRIX-BIODMATRIX-1-CC

    HCPCS Q4139: Amniomatrix or Biodmatrix, Injectable, 1 cc

    HCPCS-LEVEL-II-Q4256-AREA-BASED-PROCEDURAL-ADD-ON-PER-SQ-CM

    HCPCS Q4256: MLG-complete Skin Graft Material, Per Sq Cm

    HCPCS-LEVEL-II-Q5132-ADALIMUMAB-AFZB-ABRILADA-10MG-INJECTION

    HCPCS Level II Q5132: Injection, adalimumab-afzb (Abrilada), 10 mg

    HCPCS-Q0035-CARDIOKYMOGRAPHY-CARDIAC-MOTION-RECORDING

    HCPCS Level II Q0035: Cardiokymography

    HCPCS-Q0081-INFUSION-THERAPY-NON-CHEMOTHERAPEUTIC-PER-VISIT

    HCPCS Level II Q0081: Infusion Therapy, Non‑Chemotherapeutic, Per Visit

    HCPCS-Q0083-CHEMOTHERAPY-NON-INFUSION-ADMINISTRATION

    HCPCS Q0083: Chemotherapy Administration, Non-Infusion Methods

    HCPCS-Q0084-CHEMOTHERAPY-INFUSION-ADMINISTRATION-PER-VISIT

    HCPCS Q0084: Chemotherapy Infusion Administration, Per Visit

    HCPCS-Q0085-CHEMOTHERAPY-INFUSION-PLUS-OTHER-TECHNIQUES-PER-VISIT

    HCPCS Q0085: Chemotherapy Infusion Plus Other Technique(s), Per Visit

    HCPCS-Q0091-PAP-SMEAR-SPECIMEN-COLLECTION-TRANSPORT

    HCPCS Q0091: Screening Papanicolaou Smear Collection and Transport

    HCPCS-Q0092-PORTABLE-XRAY-EQUIPMENT-SETUP

    HCPCS Q0092: Set-up Portable X-ray Equipment

    Showing 1–10 of 629

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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