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    v1.0.28
    OpenPayerBilling CodesTemporary CodesHCPCS hcpcs-q4216-artacent-cord-biologic-implant-per-sq-cm
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    HCPCS Q4216: Artacent Cord Application, Per Square Centimeter

    Medicare pays $133 on average nationally for this procedure.

    HCPCS Level II code Q4216 describes billing for Artacent cord charged per square centimeter as an add-on, list separately item used when applying a biologic or tissue product; the service represents application of a cord-based graft/biologic and is typically provided in outpatient surgical settings or ambulatory procedure centers as a procedural adjunct to a primary operative procedure.

    For related coverage guidance, see recent payer policy updates: B-Hemolytic Streptococcus Testing, Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance Assays, Hepatitis Testing (A, B, C, D) Coverage Criteria.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult undergoing a reconstructive or wound coverage procedure where a biologic extracellular matrix product, billed as Q4216 (Artacent cord, per square centimeter, add-on), is used as an adjunct to a primary surgical procedure. Common scenarios include complex soft-tissue defects after tumor resection, chronic non-healing wounds (such as diabetic foot ulcers) requiring surgical debridement with placement of a biologic scaffold, or reconstructive procedures after traumatic loss of tissue where the product is applied to augment tissue regeneration.

    Workflow: The patient presents to an outpatient surgical center or hospital operating room for the primary procedure (for example, debridement, excision, or flap/skin graft). After the primary procedure code is documented and reported, the operating surgeon orders application of the biologic product. The surgical team documents product type, total square centimeters used, lot numbers, and the clinical indication in the operative note. Billing staff report the primary procedure CPT code(s) and append Q4216 as an add-on line item per square centimeter, with appropriate modifiers as indicated by clinical circumstances (for example, AS for ambulatory surgical center or 62 for two surgeons). Typical sites of service are hospital inpatient, hospital outpatient, ambulatory surgical center, or specialized wound care centers.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    11043Debridement, muscle and/or fascia (includes epidermis, dermis, subcutaneous tissue when performed); first 20 sq cm or lessOften performed prior to placement of a biologic scaffold to remove necrotic tissue and prepare the wound bed for Q4216 application.
    15271Application of skin substitute graft to trunk, arms, legs; first 100 sq cm or lessSkin substitute procedures may be performed in combination with biologic matrix placement; coder must report primary graft code with Q4216 as an add-on per square centimeter as appropriate.
    15100Split-thickness autograft, trunk, arms, legs; first 100 sq cm or lessAutografting is commonly performed after wound bed preparation; Q4216 may be used adjunctively to support graft take.
    15734Muscle, myocutaneous or fasciocutaneous free flap with microvascular anastomosisComplex reconstructions that include flap coverage may also incorporate biologic scaffold products as adjuncts; report Q4216 in addition to the primary reconstructive CPT.
    97602

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    54Modifier ‑54 (“Surgical care only”) is appended to a CPT surgical procedure when the reporting surgeon performs the intraoperative (surgical) component but does not furnish the preoperative and/or…- Use modifier -54 when the reporting surgeon provided only the intraoperative (surgical) component of a procedure and preoperative and/or postoperative management has been or will be provided by…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    56Modifier ‑56 indicates the reporting provider furnished only the preoperative management for a surgical procedure and did not perform the intraoperative or postoperative care. It is used in…- Use Modifier -56 when a provider performs only the preoperative management in a split‑care situation (one physician manages preop care while a different physician performs the intraoperative…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    208000000XPediatrics PhysicianA pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
    207P00000XEmergency Medicine PhysicianAn emergency physician focuses on the immediate decision making and action necessary to prevent death or any further disability both in the pre-hospit…
    163WL0100XLactation Consultant (Registered Nurse)Nursing Service Providers · Registered Nurse
    3104A0625XAssisted Living Facility (Mental Illness)A facility providing supportive services to individuals who can function independently in most areas of activity, but need special guidance, assistanc…
    261QR0200XRadiology Clinic/CenterAmbulatory Health Care Facilities · Clinic/Center
    332H00000XEyewear SupplierAn organization that provides spectacles, contact lenses, and other vision enhancement devices prescribed by an optometrist or ophthalmologist.
    207LH0002XHospice and Palliative Medicine (Anesthesiology) PhysicianAn anesthesiologist with special knowledge and skills to prevent and relieve the suffering experienced by patients with life-limiting illnesses. This …

    Related ICD-10-CM Codes

    24 rows

    ICD-10-CM CodeDescription
    G96.11Dural tear
    M43.16Spondylolisthesis, lumbar region
    M43.17Spondylolisthesis, lumbosacral region
    M47.12Other spondylosis with myelopathy, cervical region
    M47.13Other spondylosis with myelopathy, cervicothoracic region
    M48.07Spinal stenosis, lumbosacral region
    M50.20Other cervical disc displacement, unspecified cervical region
    M50.21Other cervical disc displacement, high cervical region
    M51.26Other intervertebral disc displacement, lumbar region
    M51.27Other intervertebral disc displacement, lumbosacral region

    Showing 1–10 of 24

    Related Payer Policy Updates

    Specialty: Infectious Disease1 / 3

    9 rows

    PolicyPayerEffective Date
    B-Hemolytic Streptococcus TestingOscar Health2026-10-01
    Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance AssaysOscar Health2026-10-01
    Hepatitis Testing (A, B, C, D) Coverage CriteriaOscar Health2026-10-01
    Lyme Disease Testing Coverage CriteriaOscar Health2026-10-01
    Pathogen Panel TestingOscar Health2026-10-01
    Diagnostic Testing of Common Sexually Transmitted InfectionsOscar Health2026-10-01
    Testing for Vector-Borne InfectionsOscar Health2026-10-01
    Coronavirus Testing in the Outpatient SettingOscar Health2026-10-01
    Testing for Diagnosis of Active or Latent TuberculosisOscar Health2026-10-01

    Related Codes

    HCPCS-LEVEL-II-Q4139-INJECTABLE-AMNIOMATRIX-BIODMATRIX-1-CC

    HCPCS Q4139: Amniomatrix or Biodmatrix, Injectable, 1 cc

    HCPCS-LEVEL-II-Q4256-AREA-BASED-PROCEDURAL-ADD-ON-PER-SQ-CM

    HCPCS Q4256: MLG-complete Skin Graft Material, Per Sq Cm

    HCPCS-LEVEL-II-Q5132-ADALIMUMAB-AFZB-ABRILADA-10MG-INJECTION

    HCPCS Level II Q5132: Injection, adalimumab-afzb (Abrilada), 10 mg

    HCPCS-Q0035-CARDIOKYMOGRAPHY-CARDIAC-MOTION-RECORDING

    HCPCS Level II Q0035: Cardiokymography

    HCPCS-Q0081-INFUSION-THERAPY-NON-CHEMOTHERAPEUTIC-PER-VISIT

    HCPCS Level II Q0081: Infusion Therapy, Non‑Chemotherapeutic, Per Visit

    HCPCS-Q0083-CHEMOTHERAPY-NON-INFUSION-ADMINISTRATION

    HCPCS Q0083: Chemotherapy Administration, Non-Infusion Methods

    HCPCS-Q0084-CHEMOTHERAPY-INFUSION-ADMINISTRATION-PER-VISIT

    HCPCS Q0084: Chemotherapy Infusion Administration, Per Visit

    HCPCS-Q0085-CHEMOTHERAPY-INFUSION-PLUS-OTHER-TECHNIQUES-PER-VISIT

    HCPCS Q0085: Chemotherapy Infusion Plus Other Technique(s), Per Visit

    HCPCS-Q0091-PAP-SMEAR-SPECIMEN-COLLECTION-TRANSPORT

    HCPCS Q0091: Screening Papanicolaou Smear Collection and Transport

    HCPCS-Q0092-PORTABLE-XRAY-EQUIPMENT-SETUP

    HCPCS Q0092: Set-up Portable X-ray Equipment

    Showing 1–10 of 629

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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    Removal of devitalized tissue from wound(s), selective debridement, without anesthesia (e.g., sharps, enzymatic, mechanical), first 20 sq cm or less
    In outpatient wound care settings, selective debridement precedes application of biologic products billed with Q4216.