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    v1.0.28
    OpenPayerBilling CodesPathology and Laboratory ServicesHCPCS hcpcs-p9046-albumin-25-percent-20ml-infusion
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    HCPCS Level II P9046: Infusion, Albumin (Human) 25%, 20 mL

    HCPCS Level II code P9046 describes an infusion product of human albumin 25% in a 20 mL vial, used as an intravenous colloid volume expander; the service is supply of the albumin solution for administration, typically delivered in an infusion/IV therapy setting such as an outpatient infusion center, hospital inpatient ward, or clinic where parenteral therapies are administered.

    For related coverage guidance, see recent payer policy updates: Epithelial Cell Cytology in Breast Cancer Risk Assessment, Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only), Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only).

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    Clinical & Coding Specifications

    Clinical Context

    A 68-year-old male with chronic liver disease and hypoalbuminemia presents to the outpatient infusion center for administration of human albumin 25%, 20 mL (P9046) to treat symptomatic low serum albumin and to support oncotic pressure during a paracentesis procedure. The clinical workflow begins with physician evaluation documenting the indication (for example, volume management for large-volume paracentesis or correction of severe hypoalbuminemia), informed consent, baseline vital signs and weight, verification of allergies, and review of recent laboratory values including serum albumin and coagulation profile. A registered nurse verifies the medication order in the electronic health record, prepares the 25% albumin in the supplied 20 mL vial, establishes peripheral IV access, and administers the product per facility protocol while monitoring for infusion reactions. Post-infusion monitoring includes vital signs, assessment for signs of fluid overload or allergic reaction, and documentation of lot number and expiration date for traceability. The typical site of service is an outpatient infusion center, ambulatory surgical center (if given during a procedure such as paracentesis), or hospital inpatient unit when administered as part of acute care management.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    36415Collection of venous blood by venipuncturePerformed before infusion for laboratory tests (serum albumin, coagulation panel) that guide albumin use
    96365Intravenous infusion, for therapy, prophylaxis, or diagnosis; initial, up to 1 hourOften used to report the infusion administration service when billing for administration time of IV-administered therapies
    96521Irrigation of implanted venous access devicePerformed when using an implanted port or catheter to administer albumin
    36000Introduction of needle or intracatheter into peripheral veinMay be reported when peripheral IV access is placed specifically for administration
    36556Placement of a non-tunneled centrally inserted central venous catheterReported when central access is required for administration in complex cases

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    82Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    363L00000XNurse Practitioner(1) A registered nurse provider with a graduate degree in nursing prepared for advanced practice involving independent and interdependent decision mak…
    174400000XSpecialistAn individual educated and trained in an applied knowledge discipline used in the performance of work at a level requiring knowledge and skills beyond…
    163WL0100XLactation Consultant (Registered Nurse)Nursing Service Providers · Registered Nurse
    261QC0050XCritical Access Hospital Clinic/CenterAn outpatient entity, facility, or distinct part of a facility within or affiliated with a Critical Access Hospital that provides access to primary ca…
    261QV0200XVA Clinic/CenterAmbulatory Health Care Facilities · Clinic/Center
    2251C2600XCardiopulmonary Physical TherapistA licensed physical therapist, including but not limited to an individual who is a Board Certified Specialist in Cardiovascular & Pulmonary Physical T…
    225500000XRespiratory/Developmental/Rehabilitative Specialist/TechnologistGeneral classification identifying individuals who are trained on a specific piece of equipment or technical procedure.

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 4

    10 rows

    PolicyPayerEffective Date
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only)UnitedHealthcare2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only)UnitedHealthcare2026-08-01
    Antibody-Drug ConjugatesPremera Bluecross2026-08-01
    Chimeric Antigen Receptor (CAR) T-Cell TherapyColorado Rocky Mountain Health Plans2026-08-01
    Allogeneic Hematopoietic Progenitor Cell TherapyAmbetter Georgia2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Idaho Only)UnitedHealthcare2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for New Jersey Only)UnitedHealthcare2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Ohio Only)UnitedHealthcare2026-08-01
    Reblozyl (luspatercept-aamt) Medical Benefit Drug PolicyUnitedHealthcare2026-08-01

    Related Codes

    HCPCS-LEVEL-II-P2029-CONGO-RED-BLOOD-TEST

    HCPCS P2029: Congo red, blood

    HCPCS-P2028-CEPHALIN-FLOCCULATION-BLOOD

    HCPCS Level II P2028: Cephalin Flocculation, Blood

    HCPCS-P2031-HAIR-ANALYSIS-EXCLUDING-ARSENIC

    HCPCS P2031: Hair Analysis (Excluding Arsenic)

    HCPCS-P2033-THYMOL-TURBIDITY-BLOOD-LAB-TEST

    HCPCS P2033: Thymol Turbidity, Blood

    HCPCS-P2038-MUCOPROTEIN-BLOOD-SEROMUCOID-LAB-TEST

    HCPCS Level II P2038: Mucoprotein (Seromucoid) Blood Test

    HCPCS-P3000-SCREENING-PAP-SMEAR-TECHNICIAN-SUPERVISED

    HCPCS Level II P3000: Screening Papanicolaou Smear by Technician

    HCPCS-P3001-SCREENING-PAP-SMEAR-CERVICAL-VAGINAL

    HCPCS Level II P3001: Screening Papanicolaou Smear, Up to Three Smears

    HCPCS-P7001-QUANTITATIVE-URINE-BACTERIAL-CULTURE-SENSITIVITY

    HCPCS P7001: Urine Bacterial Culture, Quantitative with Sensitivity

    HCPCS-P9010-WHOLE-BLOOD-TRANSFUSION-PER-UNIT

    HCPCS Level II P9010: Blood (whole) for Transfusion, per Unit

    HCPCS-P9011-BLOOD-SPLIT-UNIT

    HCPCS Level II P9011: Blood, Split Unit

    Showing 1–10 of 58

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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