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    v1.0.28
    OpenPayerBilling CodesMiscellaneous Medical ServicesHCPCS hcpcs-m0245-bamlanivimab-etesevimab-infusion-monitoring
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    HCPCS Level II M0245: Intravenous Infusion of Bamlanivimab and Etesevimab

    HCPCS Level II code M0245 describes an intravenous infusion of bamlanivimab and etesevimab, including the infusion procedure and post-administration monitoring; service type: monoclonal antibody IV infusion therapy, typical site of service: infusion clinic, outpatient infusion center, or hospital outpatient department.

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    Clinical & Coding Specifications

    Clinical Context

    A 68-year-old patient with multiple comorbidities (type 2 diabetes, chronic kidney disease stage 3, and obesity) presents to an outpatient infusion center within the early symptomatic window after a confirmed positive SARS-CoV-2 NAAT test. The patient meets emergency use criteria for treatment with the combined monoclonal antibody regimen bamlanivimab and etesevimab. After telephonic pre-screening for allergy history and anticoagulation status, the patient arrives for same-day intravenous infusion.

    The clinical workflow includes: pre-infusion nursing assessment (vitals, symptom review, medication reconciliation), verification of indication and consent by the ordering clinician, pharmacy preparation and verification of M0245 product and dose, IV access placement, administration of the infusion over the recommended infusion time, continuous monitoring for infusion-related reactions, post-infusion observation for an appropriate monitoring period, documentation of drug lot number and administration times, and discharge instructions. The service includes the infusion and post-administration monitoring as described by the billing code M0245.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    96365Intravenous infusion, initial, up to 1 hourMay be reported for concurrent IV medication administration and infusion time documentation when allowed; complements M0245 when facility requires separate infusion procedure coding.
    96366Intravenous infusion, each additional hourUse if infusion extends beyond the first hour and facility billing requires hourly infusion units.
    36415Collection of venous blood by venipuncturePerformed pre-infusion for baseline labs or SARS-CoV-2 testing confirmation when needed.
    99024Postoperative follow-up visit, typically after routine surgeryNot typically used; included here as unrelated example—Data not available in the input.
    99211Office or other outpatient visit for established patient, minimal problemsUse for brief evaluation or nursing visit associated with infusion follow-up in clinic workflows.

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    163W00000XRegistered Nurse(1) A registered nurse is a person qualified by graduation from an accredited nursing school (depending upon schooling, a registered nurse may receive…
    251E00000XHome Health AgencyA public agency or private organization, or a subdivision of such an agency or organization, that is primarily engaged in providing skilled nursing se…
    3336C0003XCommunity/Retail PharmacyA pharmacy where pharmacists store, prepare, and dispense medicinal preparations and/or prescriptions for a local patient population in accordance wit…
    261QH0700XHearing and Speech Clinic/CenterAn entity, facility, or distinct part of a facility providing diagnostic, treatment, prescriptive, and therapy services related to congenital and acqu…
    163WC3500XCardiac Rehabilitation Registered NurseNursing Service Providers · Registered Nurse
    152WL0500XLow Vision Rehabilitation OptometristOptometrists who specialize in low-vision care having training to assess visual function, prescribe low-vision devices, develop treatment plans, and r…

    Related ICD-10-CM Codes

    26 rows

    ICD-10-CM CodeDescription
    A41.9Sepsis, unspecified organism
    B34.2Coronavirus infection, unspecified
    B97.29Other coronavirus as the cause of diseases classified elsewhere
    D50.9Iron deficiency anemia, unspecified
    D64.9Anemia, unspecified
    E11.9Type 2 diabetes mellitus without complications
    F17.210Nicotine dependence, cigarettes, uncomplicated
    G47.33Obstructive sleep apnea (adult) (pediatric)
    I10Essential (primary) hypertension
    I50.9Heart failure, unspecified

    Showing 1–10 of 26

    Related Codes

    HCPCS-M0075-CELLULAR-THERAPY-PROCESSING-PROVISION

    HCPCS Level II M0075: Cellular Therapy

    HCPCS-M0076-PROLOTHERAPY-INJECTION-THERAPY

    HCPCS Level II M0076: Prolotherapy

    HCPCS-M0100-INTRAGASTRIC-HYPOTHERMIA-GASTRIC-FREEZING

    HCPCS Level II M0100: Intragastric Hypothermia (Gastric Freezing)

    HCPCS-M0201-IN-HOME-VACCINE-ADMINISTRATION

    HCPCS Level II M0201: In-Home Vaccine Administration

    HCPCS-M0220-TIXAGEVIMAB-CILGAVIMAB-PRE-EXPOSURE-PROPHYLAXIS

    HCPCS Level II M0220: Tixagevimab and Cilgavimab Pre-Exposure Prophylaxis

    HCPCS-M0221-TIXAGEVIMAB-CILGAVIMAB-PRE-EXPOSURE-PROPHYLAXIS-HOME-ADMINISTRATION

    HCPCS M0221: Tixagevimab and Cilgavimab Pre-Exposure Prophylaxis

    HCPCS-M0222-BEBTELOVIMAB-INTRAVENOUS-INJECTION-MONITORING

    HCPCS Level II M0222: Bebtelovimab Intravenous Injection with Monitoring

    HCPCS-M0223-BEBTELOVIMAB-INTRAVENOUS-INJECTION-HOME-MONITORING

    HCPCS M0223: Intravenous Bebtelovimab with Home Monitoring

    HCPCS-M0224-PEMIVIBART-PRE-EXPOSURE-PROPHYLAXIS-INFUSION

    HCPCS M0224: Pemivibart Intravenous Infusion for Pre-Exposure Prophylaxis

    HCPCS-M0233-TOCILIZUMAB-INFUSION-COVID19-HOSPITALIZED-ADULTS

    HCPCS Level II M0233: Tocilizumab-aazg IV Infusion, First Dose

    Showing 1–10 of 27

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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