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    v1.0.28
    OpenPayerBilling CodesChemotherapy DrugsHCPCS hcpcs-j9320-injection-streptozocin-1g
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    HCPCS Level II J9320: Streptozocin Injection, 1 Gram

    HCPCS Level II code J9320 represents a billed unit for administration of streptozocin supplied as 1 gram for injection; the service is a medication injection typically provided in oncology or infusion settings such as outpatient infusion clinics or hospital outpatient departments.

    For related coverage guidance, see recent payer policy updates: Epithelial Cell Cytology in Breast Cancer Risk Assessment, Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only), Antibody-Drug Conjugates.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 58-year-old patient with a history of metastatic pancreatic neuroendocrine tumor presents for systemic chemotherapy. The oncology team orders an intravenous antineoplastic agent, J9320 (injection, streptozocin, 1 gram). The patient arrives to an outpatient oncology infusion center. Nursing performs pre-infusion assessment including vitals, review of laboratory values (renal function, liver enzymes, complete blood count), and verification of informed consent. Streptozocin is reconstituted by pharmacy per institutional protocol and delivered to the infusion suite with the exact number of grams required. The infusion nurse confirms the drug, dose, and patient identity, establishes IV access, and administers the medication over the recommended infusion time with appropriate antiemetic prophylaxis and hydration as indicated. Post-infusion monitoring includes assessment for hypersensitivity, nausea, vomiting, and renal toxicity; documentation of lot number and amount administered is recorded in the medication administration record. Billing is submitted using HCPCS Level II code J9320 for each gram administered, with any applicable modifier to indicate payer-specific circumstances (for example JW for discarded drug portion). Typical sites of service include outpatient hospital infusion centers, physician office-based infusion suites, and freestanding oncology clinics. Typical patient scenario: adult oncology patient receiving systemic streptozocin for treatment of insulinoma or pancreatic neuroendocrine tumor, often combined with other agents or as part of a chemotherapy regimen, requiring IV administration and monitoring for renal and gastrointestinal adverse effects.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    96413Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drugCommonly used to report the administration time for an initial chemotherapy drug infusion when streptozocin is given as the primary agent.
    96415Chemotherapy administration, intravenous infusion technique; each additional hour (list separately in addition to code for primary infusion)Used when the infusion time for J9320 exceeds the initial hour and additional time must be reported.
    96417Chemotherapy administration, each additional sequential infusion of a new drug (in the same session)Used when multiple distinct IV chemotherapy drugs are administered sequentially during the same encounter alongside J9320.
    96365Intravenous infusion, for therapeutic, prophylactic, or diagnostic purposes, initial, up to 1 hourMay be used for supportive or hydration infusions administered before or after streptozocin if they meet payer criteria.
    96372Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscularUsed for separate supportive injections during the visit such as antiemetics or growth factors given subcutaneously or intramuscularly.

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    208000000XPediatrics PhysicianA pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
    364S00000XClinical Nurse SpecialistA registered nurse who, through a graduate degree program in nursing, or through a formal post-basic education program or continuing education courses…
    207RC0000XCardiovascular Disease PhysicianAn internist who specializes in diseases of the heart and blood vessels and manages complex cardiac conditions such as heart attacks and life-threaten…
    3336C0002XClinic PharmacyA pharmacy in a clinic, emergency room or hospital (outpatient) that dispenses medications to patients for self-administration under the supervision o…
    103TR0400XRehabilitation PsychologistA psychologist who specializes in the study and application of psychological principles on behalf of persons who have disability due to injury or illn…
    103TP0814XPsychoanalysis PsychologistA psychologist whose specialty is distinguished from other specialties by its body of knowledge and its intensive treatment approaches. It aims at str…
    103TE1000XDeactivated - Psychologist
    204D00000XNeuromusculoskeletal Medicine & OMM PhysicianThe Neuromusculoskeletal Medicine and Osteopathic Manipulative Medicine physician directs special attention to the neuromusculoskeletal system and its…

    Related ICD-10-CM Codes

    25 rows

    ICD-10-CM CodeDescription
    C25.0Malignant neoplasm of head of pancreas
    C25.1Malignant neoplasm of body of pancreas
    C25.2Malignant neoplasm of tail of pancreas
    C25.3Malignant neoplasm of pancreatic duct
    C25.4Malignant neoplasm of endocrine pancreas
    C25.7Malignant neoplasm of other parts of pancreas
    C25.8Malignant neoplasm of overlapping sites of pancreas
    C25.9Malignant neoplasm of pancreas, unspecified
    C78.5Secondary malignant neoplasm of large intestine and rectum
    E08.65Diabetes mellitus due to underlying condition with hyperglycemia

    Showing 1–10 of 25

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    4 rows

    PolicyPayerEffective Date
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only)UnitedHealthcare2026-08-01
    Antibody-Drug ConjugatesPremera Bluecross2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only)UnitedHealthcare2026-08-01

    Related Codes

    HCPCS-J9000-DOXORUBICIN-10MG-INJECTION

    HCPCS J9000: Doxorubicin Hydrochloride Injection, 10 mg

    HCPCS-J9003-LEUPROLIDE-INJECTABLE-CAMCEVI-1MG

    HCPCS Level II J9003: Leuprolide injectable (camcevi etm), 1 mg

    HCPCS-J9010-ALEMTUZUMAB-INJECTION-10MG

    HCPCS Level II J9010: Injection, alemtuzumab, 10 mg

    HCPCS-J9011-DATOPOTAMAB-DERUXTECAN-INJECTION-1MG

    HCPCS J9011: Datopotamab Deruxtecan Injection, 1 mg

    HCPCS-J9015-ALDESLEUKIN-INJECTION-SINGLE-USE-VIAL

    HCPCS Level II J9015: Aldesleukin Injection, Single-Use Vial

    HCPCS-J9017-ARSENIC-TRIOXIDE-INJECTION-1MG

    HCPCS J9017: Arsenic Trioxide Injection, 1 mg

    HCPCS-J9019-ASPARAGINASE-ERWINAZE-INJECTION-1000-IU

    HCPCS Level II J9019: Asparaginase (Erwinaze) Injection, 1,000 IU

    HCPCS-J9020-ASPARAGINASE-INJECTION-10000-UNITS

    HCPCS J9020: Asparaginase Injection, 10,000 Units

    HCPCS-J9021-ASPARAGINASE-RYLAZE-INJECTION-0-1-MG

    HCPCS Level II J9021: Injection, asparaginase (Rylaze), 0.1 mg

    HCPCS-J9022-ATEZOLIZUMAB-INJECTION-10MG

    HCPCS J9022: Injection, atezolizumab 10 mg

    Showing 1–10 of 227

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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    77002Fluoroscopic guidance for needle placement (limited)Included when image guidance is required for vascular access placement prior to infusion in complex cases.