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    v1.0.28
    OpenPayerBilling CodesDrugs Administered Other than Oral MethodHCPCS hcpcs-j7507-tacrolimus-oral-1mg-immediate-release
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    HCPCS Level II J7507: Tacrolimus immediate release oral 1 mg

    HCPCS Level II code J7507 represents tacrolimus, immediate release, oral, 1 mg, a formulation of the calcineurin inhibitor used for systemic immunosuppression; the service is dispensing an oral immunosuppressive medication, typically provided in pharmacy or outpatient clinic settings for patients requiring therapeutic immunosuppression following organ transplantation or for select autoimmune conditions.

    For related coverage guidance, see recent payer policy updates: Epithelial Cell Cytology in Breast Cancer Risk Assessment, Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only), Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only).

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a 45-year-old solid organ transplant recipient (kidney or liver) managed in an outpatient transplant clinic who requires maintenance immunosuppression with oral immediate-release tacrolimus. The patient presents for routine post-transplant follow-up to monitor graft function, review laboratory results (serum creatinine, liver panel, tacrolimus trough level), and receive a prescription refill for J7507 (Tacrolimus, immediate release, oral, 1 mg). The clinical workflow includes verification of medication dose and formulation, review of current interacting medications, assessment for signs of rejection or infection, ordering or reviewing therapeutic drug monitoring (tacrolimus trough level), documenting dose adjustments, and coordinating pharmacy dispensing. Typical coordination involves the transplant pharmacist for dose titration, the transplant physician (nephrologist or hepatologist) for clinical decisions, and outpatient nursing for medication reconciliation and patient education. The medication is usually dispensed through an outpatient pharmacy or specialty pharmacy and billed to the patient’s medical or pharmacy benefit depending on payer policies.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    99213Office or other outpatient visit for the evaluation and management of an established patient, typically 15 minutesCommon outpatient visit code used when a transplant recipient is seen for medication management and tacrolimus dose adjustment
    99214Office or other outpatient visit for the evaluation and management of an established patient, typically 25 minutesUsed when complexity of decision-making or time spent for therapeutic drug monitoring and medication counseling is greater
    83970Tacrolimus (FK-506) assay, quantitativeLaboratory test used to measure tacrolimus trough blood concentration to guide dosing for J7507
    36415Collection of venous blood by venipuncturePerformed when obtaining blood for tacrolimus trough level monitoring
    G0463Hospital outpatient clinic visit for assessment and management of a patientUsed when medication management occurs in a hospital outpatient transplant clinic setting

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    208000000XPediatrics PhysicianA pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
    207RN0300XNephrology PhysicianAn internist who treats disorders of the kidney, high blood pressure, fluid and mineral balance and dialysis of body wastes when the kidneys do not fu…
    207RC0000XCardiovascular Disease PhysicianAn internist who specializes in diseases of the heart and blood vessels and manages complex cardiac conditions such as heart attacks and life-threaten…
    364S00000XClinical Nurse SpecialistA registered nurse who, through a graduate degree program in nursing, or through a formal post-basic education program or continuing education courses…
    163WX1500XOstomy Care Registered NurseNursing Service Providers · Registered Nurse
    2471C3401XComputed Tomography Radiologic TechnologistA radiologic technologist who specializes in computed tomography (CT) and is appropriately educated and trained, consistent with nationally recognized…
    2470A2800XAssistant Health Information Record TechnicianNone
    2278P3800XPalliative/Hospice Certified Respiratory TherapistA coordinated plan of care to help dying patients and their families handle the burden of terminal care. Effective secretion management and relief of…

    Related ICD-10-CM Codes

    25 rows

    ICD-10-CM CodeDescription
    D47.1Chronic myeloproliferative disease
    G60.9Hereditary and idiopathic neuropathy, unspecified
    H35.30Unspecified macular degeneration
    H91.90Unspecified hearing loss, unspecified ear
    I21.9Acute myocardial infarction, unspecified
    I50.9Heart failure, unspecified
    I63.9Cerebral infarction, unspecified
    K52.9Noninfective gastroenteritis and colitis, unspecified
    K75.0Abscess of liver
    L93.0Discoid lupus erythematosus

    Showing 1–10 of 25

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    10 rows

    PolicyPayerEffective Date
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only)UnitedHealthcare2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only)UnitedHealthcare2026-08-01
    Antibody-Drug ConjugatesPremera Bluecross2026-08-01
    Chimeric Antigen Receptor (CAR) T-Cell TherapyColorado Rocky Mountain Health Plans2026-08-01
    Allogeneic Hematopoietic Progenitor Cell TherapyAmbetter Georgia2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Idaho Only)UnitedHealthcare2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for New Jersey Only)UnitedHealthcare2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Ohio Only)UnitedHealthcare2026-08-01
    Reblozyl (luspatercept-aamt) Medical Benefit Drug PolicyUnitedHealthcare2026-08-01

    Related Codes

    HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

    HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

    HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

    HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

    HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

    HCPCS Level II J0121: Omadacycline Injection, 1 mg

    HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

    HCPCS Level II J0122: Injection, eravacycline, 1 mg

    HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

    HCPCS Level II J0129: Abatacept Injection, 10 mg

    HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

    HCPCS Level II J0130: Injection abciximab, 10 mg

    HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

    HCPCS Level II J0131: Injection, Acetaminophen 10 mg

    HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

    HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

    HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

    HCPCS Level II J0133: Injection, Acyclovir 5 mg

    HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

    HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

    Showing 1–10 of 991

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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