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    v1.0.28
    OpenPayerBilling CodesDrugs Administered Other than Oral MethodHCPCS hcpcs-j3360-diazepam-injection-up-to-5-mg
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    HCPCS Level II J3360: Injection, Diazepam, up to 5 mg

    HCPCS Level II code J3360 represents an injectable formulation of diazepam, billed for administration of up to 5 mg; the service is an medication administration (injectable benzodiazepine) typically provided in outpatient infusion clinics, emergency departments, or procedural/surgical settings where parenteral sedation or anxiolysis is required.

    For related coverage guidance, see recent payer policy updates: Epithelial Cell Cytology in Breast Cancer Risk Assessment, Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only), Antibody-Drug Conjugates.

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    Clinical & Coding Specifications

    Clinical Context

    A patient in the emergency department presents with acute severe anxiety and an acute agitation episode after a traumatic event. The treating physician determines immediate short-acting benzodiazepine therapy is indicated for rapid anxiolysis and muscle relaxation. The clinician orders J3360 (injection, diazepam, up to 5 mg). A registered nurse prepares and administers the IV push or IM injection per facility protocol, documents dose, route, time, and patient response, and observes the patient for sedation, respiratory depression, and hemodynamic stability. If procedural sedation or additional monitoring is required, appropriate observation and adjunct medications or airway support are available. Billing is submitted by the facility using J3360 with applicable site-of-service modifiers (for example, emergency department or outpatient clinic) and any required payer-specific reporting. Vital signs, level of consciousness, and any adverse events are recorded in the medical record to support medical necessity and safe use of J3360.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    96372Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscularCommonly used when J3360 is administered IM; documents the injection administration procedure alongside the drug HCPCS code.
    90791Psychiatric diagnostic evaluation (no medical services)May precede administration when a focused psychiatric assessment supports acute medication needs in behavioral health settings.
    99152Moderate sedation services provided by the same physician performing the procedure (for initial 30 minutes)Used when additional sedation beyond single-dose diazepam is required and moderate sedation is documented.
    99284Emergency department visit, high severityRepresents the ED E/M level that may accompany J3360 administration for acute agitation or severe anxiety.
    93000Electrocardiogram, routine ECG with at least 12 leads; interpretation and reportPerformed before or after benzodiazepine administration in patients with cardiac risk or hemodynamic instability.

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    25CPT modifier 25 indicates that on the same day as another procedure or service, the same physician or other qualified health care professional provided a significant, separately identifiable…- When to apply: Use modifier 25 only on an E/M code to indicate the same provider delivered a significant, separately identifiable E/M service on the same day as another procedure or service — i.e.,…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    261QM1102XMilitary Outpatient Operational (Transportable) Component Clinic/Center"Non-fixed" facilities or distinct parts of a "non-fixed" facility, providing outpatient medical and dental services, primarily intended for DoD activ…
    347B00000XBusA public or private organization or business licensed to provide bus services.
    163WC0200XCritical Care Medicine Registered NurseNursing Service Providers · Registered Nurse
    1835P0018XPharmacist Clinician (PhC)/ Clinical Pharmacy SpecialistPharmacist Clinician/Clinical Pharmacy Specialist is a pharmacist with additional training and an expanded scope of practice that may include prescrip…
    207ZC0006XClinical Pathology PhysicianA pathologist deals with the causes and nature of disease and contributes to diagnosis, prognosis and treatment through knowledge gained by the labora…
    207RS0010XSports Medicine (Internal Medicine) PhysicianAn internist trained to be responsible for continuous care in the field of sports medicine, not only for the enhancement of health and fitness, but al…
    163WP0218XPediatric Oncology Registered NurseNursing Service Providers · Registered Nurse
    364SP0807XChild & Adolescent Psychiatric/Mental Health Clinical Nurse SpecialistPhysician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist

    Related ICD-10-CM Codes

    30 rows

    ICD-10-CM CodeDescription
    F11.20Opioid dependence, uncomplicated
    F11.21Opioid dependence, in remission
    F13.20Sedative, hypnotic or anxiolytic dependence, uncomplicated
    F13.21Sedative, hypnotic or anxiolytic dependence, in remission
    F19.20Other psychoactive substance dependence, uncomplicated
    F19.21Other psychoactive substance dependence, in remission
    F32.9Major depressive disorder, single episode, unspecified
    F33.1Major depressive disorder, recurrent, moderate
    F41.0Panic disorder [episodic paroxysmal anxiety]
    F41.9Anxiety disorder, unspecified

    Showing 1–10 of 30

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    4 rows

    PolicyPayerEffective Date
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only)UnitedHealthcare2026-08-01
    Antibody-Drug ConjugatesPremera Bluecross2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only)UnitedHealthcare2026-08-01

    Related Codes

    HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

    HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

    HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

    HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

    HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

    HCPCS Level II J0121: Omadacycline Injection, 1 mg

    HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

    HCPCS Level II J0122: Injection, eravacycline, 1 mg

    HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

    HCPCS Level II J0129: Abatacept Injection, 10 mg

    HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

    HCPCS Level II J0130: Injection abciximab, 10 mg

    HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

    HCPCS Level II J0131: Injection, Acetaminophen 10 mg

    HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

    HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

    HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

    HCPCS Level II J0133: Injection, Acyclovir 5 mg

    HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

    HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

    Showing 1–10 of 991

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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